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Interactions between rat C-reactive protein and adult Hymenolepis diminuta

Published online by Cambridge University Press:  01 September 1997

K. TAYLOR
Affiliation:
Present address: Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK. Parasitology Research Laboratory, Centre for Applied Entomology and Parasitology, Department of Biological Sciences, Keele University, Keele, Staffs ST5 5BG, UK
D. HOOLE
Affiliation:
Parasitology Research Laboratory, Centre for Applied Entomology and Parasitology, Department of Biological Sciences, Keele University, Keele, Staffs ST5 5BG, UK

Abstract

Interactions between adult Hymenolepis diminuta and rat C-reactive protein (CRP) were investigated in vivo and in vitro. Using an ELISA technique, serum levels of CRP were monitored in rats infected with 100 cysticercoids. Although infection increased the level of this protein in the early stages of parasitization, the increase was not significant until 35 days post-infection (p.i.). Secondary infections did not enhance the response. When H. diminuta was cultured in the presence of CRP, reduced worm motility and opaque areas were observed and electron microscopical studies revealed shedding of microtriches and lysis of the tegument. Initially, damage was restricted to the strobila which correlated with the regional distribution of phosphorylcholine as visualized using immunofluorescence.

Type
Research Article
Copyright
1997 Cambridge University Press

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