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Immunization against cerebral pathology in Plasmodium berghei-infected mice

Published online by Cambridge University Press:  06 April 2009

J. H. A. J. Curfs ,
C. C. Hermsen ,
J. H. E. TH. Meuwissen  and
W. M. C. ELING
J. H. A. J. Curfs
Affiliation:
Department of Medical Microbiology, Faculty of Medicine, Catholic University of Nijmegen, Geert Grooteplein-Z. 24, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands
C. C. Hermsen
Affiliation:
Department of Medical Microbiology, Faculty of Medicine, Catholic University of Nijmegen, Geert Grooteplein-Z. 24, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands
J. H. E. TH. Meuwissen
Affiliation:
Department of Medical Microbiology, Faculty of Medicine, Catholic University of Nijmegen, Geert Grooteplein-Z. 24, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands
W. M. C. ELING
Affiliation:
Department of Medical Microbiology, Faculty of Medicine, Catholic University of Nijmegen, Geert Grooteplein-Z. 24, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands
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Extract

The development of cerebral lesions in Plasmodium berghei-infected mice was dependent on the Strain of mice and the size of the infectious inoculum. In particular, C57B1/6J mice develop cerebral lesions when infected with low numbers of parasitized erythrocytes. By increasing the number of parasites in the infectious inoculum, the percentage of animals that develop cerebral malaria is decreased. Varying degrees of protection against the development of cerebral malaria can be obtained by several methods of immunization. (1) Injection of mice with large numbers of disrupted parasitized erythrocytes 1 or 2 weeks before the challenge infection (protection up to 70%). (2) A 2-day immunizing infection given 9 or 14 days before the challenge infection (protection up to 85%). (3) Injection of mice with plasmodial exoantigen preparations 1 week before the challenge infection (variable protection-rate, up to 100%). In all mice protected against cerebral malaria, parasitaemia is not affected by the immunizing treatment, indicating that protective mechanisms against cerebral malaria and parasitaemia are independent.

Keywords

Plasmodium bergheicerebral malariaimmunization.
Type
Research Article
Information
Parasitology , Volume 105 , Issue 1 , August 1992 , pp. 7 - 14
Copyright
Copyright © Cambridge University Press 1992

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