Hostname: page-component-78c5997874-t5tsf Total loading time: 0 Render date: 2024-11-06T09:30:18.060Z Has data issue: false hasContentIssue false
  • English
  • Français

Immunity to Trichinella spiralis II. Immunity produced by the adult worm in mice

Published online by Cambridge University Press:  06 April 2009

D. A. Denham
D. A. Denham
Affiliation:
Department of Animal Pathology, Madingley Road, Cambridge*
Get access Rights & Permissions [Opens in a new window]

Extract

It has been shown that the 5th or adult stage of Trichinella spiralis stimulates strong immunity in mice. This was shown using a transfer technique and irradiated worms. A comparison between the immunity produced by a normal infection and one which has been irradiated is made and explanations offered to explain the fact that less immunity is stimulated by irradiated larvae.

I would like to express my gratitude to H.M. Treasury and to the Agricultural Research Council for financial support during the time that this work was conducted. I would also like to thank Professor W.I.B. Beveridge, within whose department this work was conducted, for the facilities provided. I would also like to record my gratitude to Dr W. C. Campbell for the many stimulating discussions we have had on the subject of Trichinella.

Type
Research Article
Information
Parasitology , Volume 56 , Issue 4 , November 1966 , pp. 745 - 751
Copyright
Copyright © Cambridge University Press 1966

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Anderson, C. V. (1941). Immunity produced in rats by the intestinal phase of Trichinella infection. M.A. thesis, University of Kansas.Google Scholar
Anderson, C. V. & Leonard, A. B. (1940). Immunity produced in rats by the intestinal phase of Trichinella infection. J. Parasit. 26 (Suppl. 2), 42–3 (Abstr.).Google Scholar
Berntzen, A. K. (1965). Comparative growth and development of Trichinella spiralis in vitro and in vivo, with a redescription of the life-cycle. Expl Parasit. 16, 74–106.CrossRefGoogle ScholarPubMed
Campbell, W. C. (1965). Immunizing effect of enteral and enteral–parenteral infections of Trichinella spiralis in mice. J. Parasit. 51, 185–94.CrossRefGoogle ScholarPubMed
Campbell, W. C. & Cuckler, A. C. (1964). Effect of thiabendazole upon the enteral and parenteral phases of trichinosis in mice. J. Parasit. 50, 481–6.CrossRefGoogle ScholarPubMed
Denham, D. A. (1965). Studies with methyridine and Trichinella spiralis. l. Effect upon the intestinal phase in mice. Expl Parasit. 17, 10–14.CrossRefGoogle Scholar
Denham, D. A. (1966). Immunity to Trichinella spiralis. I. The immunity produced by mice to the first four days of the intestinal phase of the infection. Parasitology 56, 323–8.CrossRefGoogle Scholar
Gould, S. E., Gomberg, H. S., Bethell, F. H., Villella, J. B. & Hertz, C. S. (1955). Studies on Trichinella spiralis. IV. Effect of feeding irradiated trichinella larvae on production of immunity to reinfection. Am. J. Path. 31, 949–53.Google ScholarPubMed
Gould, S. E., Gomberg, H. S., Villella, J. B. & Hertz, C. S. (1957). Studies on Trichinella spiralis. VI. Effects of cobalt 60 and X-ray on morphology and reproduction. Am. J. Path. 33, 79–105.Google Scholar
Hendricks, J. R. (1950). The relationship between precipitin titer and number of Trichinella spiralis in the intestinal tract of mice following test infections. J. Immun. 64, 173–7.CrossRefGoogle ScholarPubMed
Hendricks, J. R. (1952). Studies in mice on the dual antibody basis of acquired resistance to Trichinella spiralis. J. Elisha Mitchell scient. Soc. 68, 12–26.Google Scholar
Kim, C. W. (1957). Immunity to Trichinella spiralis in mice infected with irradiated larvae. J. Elisha Mitchell scient. Soc. 73, 308–17.Google Scholar
Levin, A. J. & Evans, T. C. (1942). The use of roentgen radiation in locating an origin of host resistance to Trichinella spiralis infections. J. Parasit. 28, 477–83.CrossRefGoogle Scholar
Thomas, H. (1965). Beiträge sur Biologie und mikroskopischen Anatomia von Trichinella spiralis Owen (1835). Z. Tropenmed. Parasit. 16, 148–80.Google Scholar
Zaiman, H., Howard, R. G. & Miller, C. J. (1961). Immune response in rats infected with Trichinella spiralis larvae subjected to roentgen radiation. Am. J. trop. Med. Hyg. 10, 215–19.CrossRefGoogle ScholarPubMed