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Immune-dependent chemotherapy of schistosomiasis

Published online by Cambridge University Press:  06 April 2009

P. G. Fallon ,
R. O. Cooper ,
A. J. Probert  and
M. J. Doenhoff
P. G. Fallon
Affiliation:
School of Biological Sciences, University College of North Wales, Bangor, Gwynedd, LL57 2UW
R. O. Cooper
Affiliation:
School of Biological Sciences, University College of North Wales, Bangor, Gwynedd, LL57 2UW
A. J. Probert
Affiliation:
School of Biological Sciences, University College of North Wales, Bangor, Gwynedd, LL57 2UW
M. J. Doenhoff
Affiliation:
School of Biological Sciences, University College of North Wales, Bangor, Gwynedd, LL57 2UW
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Summary

Host immune responses have been shown to enhance the efficacy of several schistosomicidal drugs. The evidence derives mainly from experiments on Schistosoma mansoni infections in the mouse with their immune status variously modulated; this review emphasises praziquantel (PZQ), which is now the main drug used for treatment of human schistosomiasis. Electron microscopy and indirect immunofluorescence indicate that PZQ disrupts the integrity of the surface membranes of S. mansoni, particularly those covering the dorsal tubercles of adult male worms, and this causes antigens which are the targets of antibody attack to be revealed. We review the evidence that two S. mansoni antigens in particular are implicated in the immune-dependent action of PZQ: a 200 kDa glycoprotein and a 27 kDa antigen with non-specific esterase activity.

Keywords

ChemotherapyschistosomiasisSchistosoma mansonipraziquantelimmune-dependence
Type
Research Article
Information
Parasitology , Volume 105 , Issue S1: Chemotherapy and the immune system , January 1992 , pp. S41 - S48
Copyright
Copyright © Cambridge University Press 1992

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References

REFERENCES

Aronstein, W. S., Lewis, S. A., Norden, A. P. & Strand, M. (1986). Molecular identity of a major antigen of Schistosoma mansoni which cross-reacts with Trichinella spiralis and Fasciola hepatica. Parasitology 92, 133–51.CrossRefGoogle Scholar
Awad, A. H. H. & Probert, A. J. (1991). The effect of praziquantel on the ultrastructure of Schistosoma margreboiei. Journal of Helminthology 65, 79–88.CrossRefGoogle Scholar
Becker, B., Mehlhorn, H., Andrews, P., Thomas, H. & Ekert, K. (1980). Light and electron microscpic studies of the effect of praziquantel on Schistosoma mansoni, Dicrocoelium dendriticum and Fasciola hepatica (Trematoda) in vitro. Zeitschrift für Parasitenkunde 63, 113–28.CrossRefGoogle Scholar
Bricker, C. S., Depenbusch, J. W., Bennett, J. L. & Thompson, D. P. (1983). The relationship between tegumental disruption and muscle contraction in Schistosoma mansoni exposed to various compounds. Zeitschrift für Parasitenkunde 69, 61–71.Google Scholar
Brindley, P. J. & Sher, A. (1987). The chemotherapeutic effect of praziquantel against Schistosoma mansoni is dependent on host antibody response. The Journal of Immunology 136, 215–20.CrossRefGoogle Scholar
Brindley, P. J. & Sher, A. (1990). Immunological involvement in the efficacy of praziquantel. Experimental Parasitology 71, 245–8.Google Scholar
Brindly, P. J., Strand, M., Norden, A. P. & Sher, A. (1989). Role of host antibody in the chemotherapeutic action of praziquantel against Schistosoma mansoni: identification of target antigens. Molecular and Biochemical Parasitology 34, 99–108.CrossRefGoogle Scholar
Bueding, E. & Mansour, J. M. (1957). The relationship between inhibition of phosphofructokinase activity and the mode of action of trivalent organic antimonials on Schistosoma mansoni. British Journal of Pharmacology 12, 159–65.Google Scholar
Butterworth, A. E. (1992). Vaccines against schistosomiasis: where do we stand? Transactions of the Royal Society of Tropical Medicine 86, 1–2.Google Scholar
Capron, A., Dessaint, J. P., Capron, M. & Pierce, R. J. (1992). Vaccine strategies against schistosomiasis. Immunobiology 184, 282–94.Google Scholar
Day, T. A., Bennett, J. L. & Pax, R. A. (1992). Praziquantel: the enigmatic antiparasitic. Parasitology Today 8, 342–4.CrossRefGoogle ScholarPubMed
Doenhoff, M. J. & Bain, J. (1978). The immune- dependence of schistosomicidal chemotherapy: relative lack of efficacy of an antimonial in Schistosoma mansoni-infected mice deprived of their T-cells and the demonstration of drug-antiserum synergy. Clinical Experimental Immunology 33, 232–8.Google ScholarPubMed
Doenhoff, M. J., Modha, J. & Lambertucci, J. R. (1988). Anti-schistosome chemotherapy enhanced by antibodies specific for a parasite esterase. Immunology 65, 507–10.Google ScholarPubMed
Doenhoff, M. J., Modha, J., Lambertucci, J. R. & Mclaren, D. J. (1991). The immune dependence of chemotherapy. Parasitology Today 7, 16–18.Google Scholar
Doenhoff, M. J., Musallam, R., Bain, J. & Mcgregor, A. (1979). Schistosoma mansoni infections in T-cell deprived mice, and the ameliorating effect of administering homologous chronic infection serum. American Journal of Tropical Medicine and Hygiene 28, 260–73.Google Scholar
Doenhoff, M. K., Sabah, A. A., Fletcher, C., Webbe, G. & Bain, J. (1987). Evidence for an immune-dependent action of praziquantel on Schistosoma mansoni in mice. Transactions of the Royal Society of Tropical Medicine and Hygiene 81, 947–51.CrossRefGoogle ScholarPubMed
Dunne, D. W., Agnew, A. M., Modha, J. & Doenhoff, M. J. (1986). Schistosoma mansoni egg antigens: preparation of rabbit antisera with monospecific immunoprecipitating activity, and their use in antigen characterization. Parasite Immunology 8, 575–86.CrossRefGoogle ScholarPubMed
Flisser, A., Delgado, V. & Mclaren, D. J. (1989). Schistosoma mansoni: enhanced efficacy of praziquantel treatment in immune mice. Parasite Immunology 11, 319–28.CrossRefGoogle ScholarPubMed
Flisser, A. & Mclaren, D. J. (1989). Effect of praziquantel treatment on lung-stage larvae of Schistosoma mansoni in vivo. Parasitology 98, 203–11.CrossRefGoogle ScholarPubMed
Gonnert, R. & Andrews, P. (1977). Praziquantel, a new broad-spectrum antischistosomal agent. Zeitschrift für Parasitenkunde 52, 129–50.CrossRefGoogle Scholar
Groll, E. (1984). Praziquantel. Advances in Pharmacology and Chemotherapy 20, 219–35.Google Scholar
Harder, A., Goossens, J. & Andrews, P. (1988). Influence of praziquantel and Ca2+ on the bilayer-isotropic-hexagonal transition of model membranes. Molecular and Biochemical Parasitology 29, 55–60.CrossRefGoogle ScholarPubMed
Harnett, W. (1988). The anthelmintic action of praziquantel. Parasitology Today 4, 144–6.Google Scholar
Harnett, W. & Kusel, J. R. (1986). Increased exposure of parasite antigens at the surface of adult male Schistosoma mansoni exposed to praziquantel in vitro. Parasitology 93, 401–5.Google Scholar
Helenius, A. & Simons, K. (1977). Charge shift electrophoresis: Simple method for distinguishing between amphiphilic and hydrophilic proteins in detergent solution. Proceedings of the National Academy of Sciences 74, 529–32.Google Scholar
Kohn, A., Lopez-Alvarez, M. L. & Katz, N. (1982). Transmission and scanning electron microscopical studies in the tegument of male Schistosoma mansoni after oxamniquine treatment. Annales de Parasitologie Humaine et Comparée 57, 285–91.Google Scholar
Lambertucci, J. R., Modha, J. & Doenhoff, M. J. (1989). Schistosoma mansoni: the therapeutic efficacy of oxamniquine is enhanced by immune serum. Transactions of the Royal Society of Tropical Medicine and Hygiene 83, 362–3.Google Scholar
Leitch, B. & Probert, A. J. (1983). Scanning and transmission electron microscopy of praziquantel treated Schistosoma haematobium. Parasitology 87, LVIIV.Google Scholar
Mclaren, D. J. & Smithers, S. R. (1987). The immune response to schistosomes in experimental hosts. In The Biology of Schistosomes (eds. Rollinson, D. & Simpson, A. J. G.), pp. 233–63. Academic Press Ltd., London.Google Scholar
Mehlhorn, H., Becker, B., Andrews, P., Thomas, H. & Frenkel, J. K. (1981). In vivo and in vitro experiments on the effects of praziquantel on Schistosoma mansoni: a light and electron microscopic study. Arzneimittel-Forschung 31, 544–54.Google Scholar
Modha, J., Lambertucci, J. R., Doenhoff, M. J. & Mclaren, D. J. (1990). Immune dependence of schistosomicidal chemotherapy: an ultrastructural study of Schistosoma mansoni infected adult worms exposed to praziquantel and immune serum in vivo. Parasite Immunology 12, 321–34.Google Scholar
Moore, G. A. (1977). Ultrastructural changes due to treatment in vivo of Schistosoma mansoni with hycanthone. Transactions of the Royal Society of Tropical Medicine and Hygiene 71, 115–18.Google Scholar
Mott, K. E. (1987). Epidemiological considerations for development of a schistosome vaccine. Acta Tropica 44, Suppl. 12yes, 13–20.Google Scholar
Otubanjo, O. A. (1981). Schistosoma mansoni: Astiban induced damage to tegument and the male reproductive system. Experimental Parasitology 52, 161–70.CrossRefGoogle ScholarPubMed
Pax, R., Bennet, J. L. & Fetterer, R. (1978). A benzodiazipine derivative and praziquantel: effects on musculature of Schistosoma mansoni and Schistosoma japonicum. Naunyn-Schmiedeberg's Archives of Pharmacology 304, 309–15.Google Scholar
Pica-Mattoccia, L. & Cioli, D. (1985). Studies on the mode of action of oxamniquine and related schistosomicidal drugs. American Journal of Tropical Medicine and Hygiene 34, 112–18.CrossRefGoogle ScholarPubMed
Piper, K. P., Mott, R. F., Hockley, D. J. & Mclaren, D. J. (1991). Schistosoma mansoni: larval damage and role of effector cell(s) in the synergy between vaccine immunity and praziquantel treatment. Parasitology 103, 207–24.CrossRefGoogle ScholarPubMed
Piper, K. R., Mott, R. F. & Mclaren, D. J. (1990). Schistosoma mansoni: histological analysis of the synergistic interaction between vaccine immunity and praziquantel therapy in the lungs of mice. Parasite Immunology 12, 367–87.CrossRefGoogle ScholarPubMed
Probert, A. J. & Awad, A. H. H. (1987). Scanning electron microscopy of the tegument of adult S. margrebowiei Le Roux, 1933 with particular reference to the structure of the tubercles. Parasitology 95, 491–8.CrossRefGoogle Scholar
Reiner, E. (1981). Esterases in schistosomes: reactions with substrates and inhibitors. Acta Pharmacologie et Toxicologie 49, 72–8.CrossRefGoogle ScholarPubMed
Sabah, A. A., Fletcher, C., Webbe, G. & Donehoff, M. J. (1985). Schistosoma mansoni: reduced efficacy of chemotherapy in infected T-cell deprived mice. Experimental Parasitology 60, 348–54.CrossRefGoogle ScholarPubMed
Sauma, S. Y. & Strand, M. (1990). Identification and characterization of glycosylphosphatidylinositol-linked Schistosoma mansoni adult worm immunogens. Molecular and Biochemical Parasitology 38, 199–210.CrossRefGoogle ScholarPubMed
Sauma, S. Y., Tanaka, T. M. & Strand, M. (1991). Selective release of a glycosylphosphatidylinositol-anchored antigen from the surface of Schistosoma mansoni. Molecular and Biochemical Parasitology 46, 73–80.Google Scholar
Schepers, H., Brasser, R., Goormaghtigh, E., Duquenoy, P. & Ruysschaert, J. (1988). Mode of insertion of praziquantel and derivatives into lipid membranes. Biochemical Pharmacology 37, 1615–23.CrossRefGoogle ScholarPubMed
Shaw, M. K. (1990). Schistosoma mansoni: stage- dependent damage after in vivo treatment with praziquantel. Parasitology 100, 65–72.CrossRefGoogle ScholarPubMed
Shaw, M. K. & Erasmus, D. A. (1983a). Schistosoma mansoni: the effects of subcurative dose of praziquantel on the ultrastructure of worms in vivo. Zeitschrift für Parasitenkunde 69, 73–90.CrossRefGoogle ScholarPubMed
Shaw, M. K. & Erasmus, D. A. (1983b). Schistosoma mansoni: Dose related tegumental surface changes after in vivo treatment with praziquantel. Zeitschrift für Parasitenkunde 69, 643–53.CrossRefGoogle ScholarPubMed
Talla, I., Kongs, A., Verle, P., Belot, J., Sarr, S. & Coll, A. M. (1990). Outbreak of intestinal schistosomiasis in the Senegal River Basin. Annales de la Societe Belge de Medecine Tropicale 70, 173–80.Google Scholar
Voge, M. & Bueding, E. (1980). Schistosoma mansoni: Tegumental surface alterations induced by subcurative doses of the schistosomicide amoscanate. Experimental Parasitology 50, 251–9.CrossRefGoogle ScholarPubMed
Xiao, S., Guo, H., Xue, H., Qiu, L. & Zhang, R. (1986). Attachment of mouse neutrophils in vitro on praziquantel-damaged surface of adult Schistosoma japonicum in the presence of immune sera. Acta Pharmacologica Sinica 7, 165–70.Google ScholarPubMed
Xiao, S., Shao, B. & Yu, Y. (1984). Preliminary studies on the mode of action of Pyquiton against Schistosoma Japonicum. Chinese Medical Journal 97, 839–48.Google ScholarPubMed