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Immune responses to infections with coccidia in chickens: gut hypersensitivity

Published online by Cambridge University Press:  06 April 2009

M. Elaine Rose ,
P. L. Long  and
J. W. A. Bradley
M. Elaine Rose
Affiliation:
Houghton Poultry Research Station, Houghton, Huntingdon, Cambs. PE17 2DA
P. L. Long
Affiliation:
Houghton Poultry Research Station, Houghton, Huntingdon, Cambs. PE17 2DA
J. W. A. Bradley
Affiliation:
Houghton Poultry Research Station, Houghton, Huntingdon, Cambs. PE17 2DA
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Extract

Sporulated oocysts or oocyst hulls of Eimeria acervulina given via the crop, and oocyst juice or sporozoites inoculated directly into the in testinal lumen, were tested for their effects on the hypersensitivity of the intestines of immunized and susceptible birds. Only viable sporozoites consistently caused an increase in the permeability of the immunized intestine to macromolecules, shown by the leakage of intravenously injected dye. Repulsion of epithelium and disruption of the villi were seen more often in immunized than in susceptible chickens but there was no correlation with treatment or with dye leakage.

The hypersensitive response of immune intestines challenged with a heterologous organism was approximately half as intense as the response to homologous challenge.

The significance of these findings in relation to immunity to coccidiosis is discussed.

Type
Research Article
Information
Parasitology , Volume 71 , Issue 3 , December 1975 , pp. 357 - 368
Copyright
Copyright © Cambridge University Press 1975

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