Hostname: page-component-78c5997874-8bhkd Total loading time: 0 Render date: 2024-11-03T00:58:48.993Z Has data issue: false hasContentIssue false
  • English
  • Français

Field trials in the control of Opisthorchis viverrini with an integrated programme in endemic areas of northeast Thailand

Published online by Cambridge University Press:  06 April 2009

S. Saowakontha ,
V. Pipitgool ,
S. Pariyanonda ,
S. Tesana ,
K. Rojsathaporn  and
C. Intarakhao
S. Saowakontha
Affiliation:
Departments of Medicine, Parasitology, Pharmacology and Community Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
V. Pipitgool*
Affiliation:
Departments of Parasitology, Pharmacology and Community Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
S. Pariyanonda
Affiliation:
Departments of Parasitology, Pharmacology and Community Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
S. Tesana
Affiliation:
Departments of Parasitology, Pharmacology and Community Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
K. Rojsathaporn
Affiliation:
Departments of Pharmacology and Community Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
C. Intarakhao
Affiliation:
Community Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
*
*Reprint requests to: Vichit Pipitgool, Department of Parasitology, Faculty of Medicin, Khon Kaen Univeristy, Khon Kaen 40002, Thailand.
Get access Rights & Permissions [Opens in a new window]

Summary

A control programme of opisthorchiasis was carried out for three years in three villages of northeast Thailand in order to compare the effectiveness of two intervention measures. The intervention measures employed were to give praziquantel treatment to all infected people either once (village I) or twice (village II) per year with the integration of regular health education and sanitation improvement. A control village (village III) received no intervention during the study. Sampling of the population in these villages to estimate prevalence, intensity, reinfection and incidence of infection as well as knowledge of opisthorchiasis and number of latrines was performed at 6 monthly intervals throughout the duration of the study. At the initial assessment, there were no significant differences in the prevalence and intensity of infection of villages I and II. Both values were greatly reduced when assessed 6 months after the initiation of treatment, and the decrease in prevalence and intensity of infection did not differ between villages I and II. The control village (village III), during the first 2 years, exhibited slight variation in the prevalence and intensity, and these decreased considerably in the third year of the study. The reinfection rate per 6 months in villages I and II was nearly equal. The incidence rate per 6 months in the two treated villages was lower than that of the control village. Marked improvement in knowledge of opisthorchiasis, behavioural changes of eating raw fish and increased numbers of latrines was evident in all of the villages during this study. The study showed that the effectiveness of annual drug treatment is similar to that of 6 monthly treatments when combined with regular health education and sanitation improvement.

Keywords

integrated programmeopisthorchiasis controlpraziquantel.
Type
Research Article
Information
Parasitology , Volume 106 , Issue 3 , April 1993 , pp. 283 - 288
Copyright
Copyright © Cambridge University Press 1993

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Bunnag, D. & Harinasuta, T. (1980). Studies on the chemotherapy of human opisthorchiasis in Thailand. I. Clinical trial of Praziquantel. Southeast Asian Journal of Tropical Medicine and Public Health 11, 528–32.Google ScholarPubMed
Bunnag, D. & Harinasuta, T. (1981). Studies on the chemotherapy of human opisthorchiasis. III. Minimum effective dose of Praziquantel. Southeast Asian Journal of Tropical Medicine and Public Health 12, 413–17.Google ScholarPubMed
Elkins, D. B., Haswell-Elkins, M. R., Mairiang, E., Mairiang, P., Sithithaworn, P., Kaewkes, S., Bhudisawasdi, V. & Uttaravichien, T. (1990). A high frequency of hepatobiliary disease and suspected cholangiocarcinoma associated with heavy Opisthorchis viverrini infection in a small community in north-east Thailand. Transactions of the Royal Society of Tropical Medicine and Hygiene 84, 715–19.CrossRefGoogle Scholar
Harinasuta, C. & Harinasuta, T. (1984). Opisthorchis viverrini: life-cycle, intermediate hosts, transmission to man and geographical distribution in Thailand. Arzneimittel Forschung/Drug Research 34, 1164–7.Google Scholar
Harinasuta, T., Riganti, M. & Bunnag, D. (1984). Opisthorchis viverrni: pathogenesis and clinical features. Arzneimittel Forschung /Drug Research 34, 1164–9.Google ScholarPubMed
Preuksaraj, S. (1984). Public health aspects of Opisthorchiasis in Thailand. Arzneimittel Forschung/Drug Research 34, 1119–20.Google ScholarPubMed
Pungpak, S., Bunnag, D., Riganti, M. & Harinasuta, T. (1985). Clinical features in severe opisthorchiasis viverrini. Southeast Asian Journal of Tropical Medicine and Public Health 16, 405–9.Google ScholarPubMed
Ritchie, L. S. (1984). An ether sedimentation technique for routine stool examinations. Bulletin of the United States Army Medical Department 8, 326.Google Scholar
Sadun, E. H. (1955). Studies on Opisthorchis viverrini in Thailand. American Journal of Hygiene 62, 81–115.Google ScholarPubMed
Sornmani, S., Vivatanasesth, P., Impand, P., Phatihatakorn, W. & Sitabutra, P. (1984 a). Infection and re-infection rates of opisthorchiasis in the Water Resource Development Area of Nam Pong Project, Khon Kaen Province, northeast Thailand. Annals of Tropical Medicine and Parasitology 78, 649–56.CrossRefGoogle Scholar
Sornmani, S., Schelp, E. P., Vivatanasesth, P., Phatihatakorn, W., Impand, P., Sitabutra, P., Worasan, P. & Preuksaraj, S. (1984 b). A pilot project for controlling O. viverrini infection in Nong Wai, Northeast Thailand, by applying praziquantel and other measures. Arzneimittel Forschung/Drug Research 34, 1231–4.Google ScholarPubMed
Stoll, N. R. (1923). Investigations on the control of hookworm disease. XV. An effective method of counting hookworm eggs in feces. American Journal of Hygiene 3, 59–70.Google Scholar
Upatham, E. S., Viyanant, V., Kurathong, S., Rojborwonwitaya, J., Brockelman, W. Y., Ardsungnoen, S., Lee, P. & Vajrasthira, S. (1984). Relationship between prevalence and intensity of Opisthorchis viverrini infection, and clinical symptoms and signs in a rural community in Northeast Thailand. Bulletin of the World Health Organization 62, 451–61.Google Scholar
Upatham, E. S., Viyanant, V., Brockelman, W. Y., Kurathong, S., Lee, P. & Kraengraeng, R. (1988). Rate of re-infection by Opisthorchis viverrini in an endemic Northeast Thai community after chemotherapy. International Journal for Parasitology 18, 643–9.CrossRefGoogle Scholar
Vivatanasesth, P., Sornmani, S., Schelp, F. P., Impand, P., Sitabutra, P., Preuksaraj, S. & Harinasuta, C.(1982). Mass treatment of opisthorchiasis in Northeast Thailand. Southeast Asian Journal of Tropical Medicine and Public Health 13, 609–13.Google ScholarPubMed