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Effect of Plasmodium yoelii nigeriensis infection on hepatic and splenic glutathione-S-transferase(s) in Swiss albino and db/+ mice: efficacy of mefloquine and menadione in antimalarial chemotherapy

Published online by Cambridge University Press:  13 March 2007

R. AHMAD  and
A. K. SRIVASTAVA
R. AHMAD
Affiliation:
Division of Biochemistry, P.O. Box No. 173, Central Drug Research Institute, Chattar Manzil Palace, Lucknow-226001, India
A. K. SRIVASTAVA*
Affiliation:
Division of Biochemistry, P.O. Box No. 173, Central Drug Research Institute, Chattar Manzil Palace, Lucknow-226001, India
*
*Corresponding author. Tel: +91 522 2612411 18 (Ext. 4346). Fax: +91 522 2623938. E-mail: [email protected]
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Summary

The present report deals with the status of hepatic and splenic glutathione-S-transferase (GST) activities in mice during experimental infection with Plasmodium yoelii nigeriensis and subsequent treatment of infected mice with mefloquine (Mf) and menadione (Md). The infection caused significant decline in the hepatic and splenic glutathione-S-transferase (GST) activities of albino and db/+ mice. The decline was observed in the levels of both cytosolic and microsomal GST(s) of liver and spleen in both types of mice. Intraperitoneal administration of mefloquine at a dose of 5 mg/kg and menadione at a dose of 100 mg/kg, twice daily from day 1 p.i. (day 0) until day 10, caused restoration in the levels of hepatic as well as splenic GST(s), albeit to varying degrees. Mf was able to suppress parasitaemia by day 5 in the case of albino mice and by day 3 in the case of db/+ mice but was unable to cure both types of mice completely. On the other hand, Md caused a delay in maturation of infection in both cases, but could not cure the mice.

Keywords

Plasmodium yoelii nigeriensismalariaparasitaemiaglutathioneglutathione-S-transferase(s)antimalarialsmefloquinemenadionedb/+ mice
Type
Research Article
Information
Parasitology , Volume 134 , Issue 7 , July 2007 , pp. 931 - 938
Copyright
Copyright © Cambridge University Press 2007

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