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A comparison of multiplication rates in primary and challenge infections of Trypanosoma brucei bloodstream forms

Published online by Cambridge University Press:  06 April 2009

L. M. L. McLintock ,
C. M. R. Turner  and
K. Vickerman
L. M. L. McLintock
Affiliation:
Department of Zoology, University of Glasgow, Glasgow G12 8QQ
C. M. R. Turner
Affiliation:
Department of Zoology, University of Glasgow, Glasgow G12 8QQ
K. Vickerman
Affiliation:
Department of Zoology, University of Glasgow, Glasgow G12 8QQ
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Summary

The hypothesis that division of Trypanosoma brucei slender bloodstream forms is dependent upon the availability of a host-derived growth factor has been tested by superimposing challenge doses of slender-form trypanosomes onto preexisting infections at a time during the primary infection when stumpy forms predominated. The challenge populations grew in the doubly-infected mice indicating that depletion of a putative growth factor by the expanding population of the primary infection had not prevented division of the trypanosomes although slight reductions in multiplication rates were observed. This effect was independent of the variable antigen type (VAT) of the trypanosomes and of their stock of origin.

Keywords

Trypanosoma bruceigrowthdifferentiationhost-derived growth factor
Type
Research Article
Information
Parasitology , Volume 101 , Issue 1 , August 1990 , pp. 49 - 55
Copyright
Copyright © Cambridge University Press 1990

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