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Commercialisation of a recombinant vaccine against Boophilus microplus

Published online by Cambridge University Press:  06 April 2009

P. Willadsen ,
P. Bird ,
G. S. Cobon  and
J. Hungerford
P. Willadsen
Affiliation:
CSIRO Division of Tropical Animal Production, Meiers Rd., Indooroopilly, Queensland, Australia4068
P. Bird
Affiliation:
CSIRO Division of Tropical Animal Production, Meiers Rd., Indooroopilly, Queensland, Australia4068
G. S. Cobon
Affiliation:
Biotech Australia, PO Box 20, Roseville, New South Wales, Australia2069
J. Hungerford
Affiliation:
Biotech Australia, PO Box 20, Roseville, New South Wales, Australia2069
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Summary

Increasingly, there is need for methods to control cattle tick (Boophilus microplus) infestations by the use of non-chemical technology. This need is brought about by a mixture of market forces and the failure or inadequacy of existing technology. A recombinant vaccine has now been developed against the tick. This vaccine relies on the uptake with the blood meal of antibody directed against a critical protein in the tick gut. The isolation of the vaccine antigen, Bm86, and its production as a recombinant protein is briefly described. The vaccine has been tested in the field, has been taken through the full registration process and is now in commercial use in Australia. A related development has occurred in Cuba. The potential for improvement of the current vaccine and for the development of similar vaccines against other haematophagous parasites is discussed.

Keywords

Boophilus microplustick vaccinerecombinant vaccinefield trial
Type
Research Article
Information
Parasitology , Volume 110 , Supplement S1: Symposia of the British Society for Parasitology Volume 32:Parasite vaccines , March 1995 , pp. S43 - S50
Copyright
Copyright © Cambridge University Press 1995

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