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Chloroquine containing liposomes in the chemotherapy of murine malaria

Published online by Cambridge University Press:  06 April 2009

P. A. M. Peeters ,
Caroline W. E. M. Huiskamp ,
W. M. C. Eling  and
D. J. A. Crommelin
P. A. M. Peeters
Affiliation:
Department of Pharmaceutics, Faculty of Pharmacy, University of Utrecht, Croesestraat 79, 3522 AD Utrecht, The Netherlands
Caroline W. E. M. Huiskamp
Affiliation:
Department of Pharmaceutics, Faculty of Pharmacy, University of Utrecht, Croesestraat 79, 3522 AD Utrecht, The Netherlands
W. M. C. Eling
Affiliation:
Department of Cell Biology and Histology, University of Nijmegen, 6500 HB Nijmegen, The Netherlands
D. J. A. Crommelin*
Affiliation:
Department of Pharmaceutics, Faculty of Pharmacy, University of Utrecht, Croesestraat 79, 3522 AD Utrecht, The Netherlands
*
*To whom correspondence should be addressed.
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Summary

In this study, the advantage of the use of chloroquine (CQ) containing liposomes (lipCQ) over free CQ in the chemotherapy of murine malaria (Plasmodium berghei) was demonstrated. The maximum permissible dose per intraperitoneal injection was 0·8 and 10 mg for CQ and lipCQ, respectively. An increase in therapeutic and prophylactic efficacy of lipCQ in comparison with free CQ at a 0·8 mg CQ dose level was found. It was possible to obtain 100% efficacy (injection at day 5 after infection; parasitaemia 4–8%) with one single intraperitoneal injection of 6 mg lipCQ. Moreover, the ability to increase the doses of CQ per injection after liposome encapsulation allowed successful treatment of infections with CQ-resistant Plasmodium berghei which could not be cured by a 7-day course with the maximum tolerable dose of free CQ of 0·8 mg/mouse/day.

Keywords

Liposome encapsulated chloroquinePlasmodium berghei infectionssustained releasechemotherapy
Type
Research Article
Information
Parasitology , Volume 98 , Issue 3 , June 1989 , pp. 381 - 386
Copyright
Copyright © Cambridge University Press 1989

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