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Action of cyclosporin A on the tapeworms Hymenolepis microstoma, H. diminuta and Mesocestoides corti in vivo

Published online by Cambridge University Press:  06 April 2009

L. H. Chappell ,
J. M. Wastling  and
Hilary Hurd
L. H. Chappell
Affiliation:
1Department of Zoology, University of Aberdeen, Tillydrone Avenue, Aberdeen AB9 2TN
J. M. Wastling
Affiliation:
1Department of Zoology, University of Aberdeen, Tillydrone Avenue, Aberdeen AB9 2TN
Hilary Hurd
Affiliation:
2Department of Biological Sciences, University of Keele, Keele ST5 5BG
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Summary

The in vivo activity of two cyclosporins, cyclosporin A (CsA) and a non-immunosuppressive derivative of dihydrocylosporin A (DHCsA-d) against three tapeworms, Hymenolepis microstoma, H. diminuta and Mesocestoides corti, has been assessed. CsA reversibly reduced the dry weight of H. microstoma in the mouse, briefly delayed oviposition and had a statistically significant effect on worm numbers recovered. Oral and subcutaneous treatments of both CsA and DHCsA-d were effective in reducing worm weight; juvenile worms were most susceptible but worms of all ages responded to drug by a dramatic reduction in weight from which they recovered. Multiple courses of CsA were no more active than single courses of treatment but dose response suggested that a threshold level of drug was necessary to evoke activity. By contrast, H. diminuta in the rat was completely unaffected by CsA but no explanation for the differences in drug response by these two closely related helminths is forthcoming. Mesocestoides corti responded reversibly to CsA in the mouse by a reduction in asexual proliferation of both liver and peritoneal cavity tetrathyridia. The data presented argue in favour of a range of anti-parasitic activities by cyclosporins but the details of the various putative modes of action remain to be defined.

Keywords

cyclosporin AHymenolepis microstomaHymenolepis diminutaMesocestoides corti
Type
Research Article
Information
Parasitology , Volume 98 , Issue 2 , April 1989 , pp. 291 - 299
Copyright
Copyright © Cambridge University Press 1989

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