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Accelerated expulsion of adult Trichinella spiralis in mice given lymphoid cells and serum from infected donors

Published online by Cambridge University Press:  06 April 2009

D. Wakelin  and
M. Lloyd
D. Wakelin
Affiliation:
Wellcome Laboratories for Experimental Parasitology, University of Glasgow, Bearsden Road, Glasgow, G61 1QH
M. Lloyd
Affiliation:
Wellcome Laboratories for Experimental Parasitology, University of Glasgow, Bearsden Road, Glasgow, G61 1QH
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Summary

Immunity to the adult stage of Trichinella spiralis, assessed by an acceleration of worm expulsion, was transferred to recipient mice with mesenteric lymph node cells (MLNC) or serum taken from infected donors. Immunity was transferred most effectively by MLNC taken from donors infected for 8 days, i.e. donors actively responding to infection. Transfer of both MLNC and serum brought about a marked acceleration of worm expulsion in all cases, even where MLNC or serum given separately failed to transfer a significant degree of immunity.

Type
Research Article
Information
Parasitology , Volume 72 , Issue 3 , June 1976 , pp. 307 - 315
Copyright
Copyright © Cambridge University Press 1976

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