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Prodromal depression in pancreatic cancer: Retrospective evaluation on ten patients

Published online by Cambridge University Press:  24 June 2014

Johan Sebti ,
Françoise Desseigne  and
Pierre Saltel
Johan Sebti*
Affiliation:
Department of Supportive Care, Centre Léon Bérard, Lyon, France
Françoise Desseigne
Affiliation:
Department of Digestive Oncology, Centre Léon Bérard, Lyon, France
Pierre Saltel
Affiliation:
Department of Supportive Care, Centre Léon Bérard, Lyon, France
*
Address correspondence and reprint requests to: John Sebti, 236 rue Andre Philip, 69003 Lyon, France. E-mail: [email protected]
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Abstract

Objective:

Since the description by Yaskin in 1931, it has been observed that pancreatic cancer and depression are two clinical entities that share a high affinity. This observation relies on the higher incidence of depressive syndromes associated with pancreatic cancer than in any other type of digestive tumor, and on the possible occurrence of depressive symptoms several months before the diagnosis of cancer. We present here a series of cases whose screening returned positive for depression-related diagnoses in the months prior to revelation of the cancer.

Method:

We employed a structured psychiatric interview based on DSM–IV criteria (SCID–I). The diagnoses considered were major depressive episode, minor depressive episode, and subsyndromal depression. All subjects were free of psychiatric history.

Results:

Some 15 patients were initially included: 10 presented compatible criteria for a past depressive episode, 2 presented a major depressive episode, 4 met the diagnosis of minor depression, and 4 evidenced subsyndromal depression over the one-year period prior to cancer diagnosis.

Significance of results:

This series of cases is consistent with previous work on the subject that suggested an increased vulnerability to depressive events in the premorbid phase of pancreatic cancer. If the possibility of depressive syndromes constituting the early stages of neoplastic disease is a common idea, it is still impossible to determine the natural history of these two disorders and therefore their causal linkage.

Keywords

CancerPsycho-oncologyPancreasMood disordersDepression assessment
Type
Case Report
Information
Palliative & Supportive Care , Volume 13 , Issue 3 , June 2015 , pp. 801 - 807
Copyright
Copyright © Cambridge University Press 2014 

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References

REFERENCES

Angelino, A.F. & Treisman, G.J. (2001). Major depression and demoralization in cancer patients: Diagnostic and treatment considerations. Supportive Care in Cancer, 9, 344–349.Google Scholar
Boyd, A.D., Brown, D., Henrickson, C., et al. (2012a). Screening for depression, sleep-related disturbances, and anxiety in patients with adenocarcinoma of the pancreas: A preliminary study. The Scientific World Journal, 2012, 650707. Epub ahead of print May 22. doi: 10.1100/2012/650707.Google Scholar
Boyd, C.A., Benarroch-Gampel, J., Sheffield, K.M., et al. (2012b). The effect of depression on stage at diagnosis, treatment and survival on pancreatic adenocarcinoma. Surgery, 152(3), 403–413.Google Scholar
Breitbart, W., Rosenfeld, B., Tobias, K., et al. (2014). Depression, cytokines, and pancreatic cancer. Psycho-Oncology, 23(3), 339–345.Google Scholar
Carney, C.P., Jones, L., Woolson, R.F., et al. (2003). Relationship between depression and pancreatic cancer in the general population. Psychosomatic Medicine, 65(5), 884–888.Google Scholar
Cornelius, J.R., Soloff, P.H. & Miewald, B.K. (1986). Behavioral manifestations of paraneoplastic encephalopathy. Biological Psychiatry, 7, 686–690.Google Scholar
First, M.B., Spitzer, R.L., Gibbon, M., et al. (1996). The structured clinical interview for DSM–III–R (SCID), II: Multisite test–retest reliability. Archives of General Psychiatry, 49(8), 630–636.Google Scholar
Fras, I., Litin, E.M. & Pearson, J.S. (1967). Comparison of psychiatric symptoms in carcinoma of the pancreas with those in some other intra-abdominal neoplasms. The American Journal of Psychiatry, 123, 1553–1562.Google Scholar
Green, A.I. & Austin, C.P. (1993). Psychopathology of pancreatic cancer. A psychobiologic probe. Psychosomatics, 34, 208–221.Google Scholar
Holland, J.C., Korzun, A.H., Tross, S., et al. (1986). Comparative psychological disturbance in patients with pancreatic and gastric cancer. The American Journal of Psychiatry, 143, 982–986.Google Scholar
Jemal, A., Siegel, R., Xu, J., et al. (2010). Cancer statistics, 2010. CA: A Cancer Journal for Clinicians, 60(5), 277–300.Google Scholar
Jia, L., Jiang, S.M., Shang, Y.Y., et al. (2010). Investigation of the incidence of pancreatic cancer–related depression and its relationship with the quality of life of patients. Digestion, 82(1), 4–9.Google Scholar
Joffe, R.T., Rubinow, D.R., Denicoff, K.D., et al. (1986). Depression and carcinoma of the pancreas. General Hospital Psychiatry, 8, 241–245.Google Scholar
Judd, L.L., Rapaport, M.H., Paulus, M.P., et al. (1994). Subsyndromal symptomatic depression: A new mood disorder? Journal of Clinical Psychiatry, 55, 18–28.Google Scholar
Kelsen, D.P., Portenoy, R.K., Thaler, H.T., et al. (1995). Pain and depression in patients with newly diagnosed pancreas cancer. Journal of Clinical Oncology, 13(3), 748–755.Google Scholar
Kessler, R.C., Zhao, S., Blazer, D.G., et al. (1997). Prevalence, correlates, and course of minor depression and major depression in the National Comorbidity Survey. Journal of Affective Disorders, 45, 19–30.Google Scholar
Maes, M., Yirmyia, R., Noraberg, J., et al. (2009). The inflammatory and neurodegenerative (I&ND) hypothesis of depression: Leads for future research and new drug developments in depression. Metabolic Brain Disease, 24, 27–53.Google Scholar
Makrilia, N., Indeck, B., Syrigos, K., et al. (2009). Depression and pancreatic cancer: A poorly understood link. Journal of the Pancreas, 10(1), 69–76.Google Scholar
Massie, M.J. (2004). Prevalence of depression in patients with cancer. Journal of the National Cancer Institute Monographs, 32, 57–71.Google Scholar
Mayr, M. & Schmid, R. (2010a). Pancreatic cancer and depression: Myth and truth. BMC Cancer, 10, 569.Google Scholar
Mayr, M. & Schmid, R. (2010 b). Depression in pancreatic cancer: Sense of impending doom. Digestion, 82, 369–376.Google Scholar
Mesquita, A.R., Correia-Neves, M., Roque, S., et al. (2008). IL-10 modulates depressive-like behavior. Psychiatric Research, 43(2), 89–97.Google Scholar
Mokhtari, M., Arfken, C. & Boutros, N. (2013). The DEX/CRH test for major depression: A potentially useful diagnostic test. Psychiatry Research, 208(2), 131–139.Google Scholar
Passik, S.D. & Breitbart, W. (1996). Depression in patients with pancreatic carcinoma. Cancer Supplement, 78(3 Suppl.), 615–626.Google Scholar
Passik, S.D. & Roth, A.J. (1999). Anxiety symptoms and panic attacks preceding pancreatic cancer diagnosis. Psycho-Oncology, 8, 268–272.Google Scholar
Pincus, H.A., Davis, W.W. & McQueen, L.E. (1999). “Subthreshold” mental disorders: A review and synthesis of studies on minor depression and other “brand names.” The British Journal of Psychiatry, 174, 288–296.Google Scholar
Raison, C.L., Capuron, L. & Miller, A.H. (2006). Cytokines sing the blues: Inflammation and the pathogenesis of depression. Trends in Immunology, 27(1), 24–31.Google Scholar
Rapaport, M.H., Judd, L.L., Schettler, P.J., et al. (2002). A descriptive analysis of minor depression. The American Journal of Psychiatry, 59, 637–643.Google Scholar
Steel, J.L., Geller, D.A., Gamblin, T.C., et al. (2007). Depression, immunity, and survival in patients with hepatobiliary carcinoma. Journal of Clinical Oncology, 25, 2397–2405.Google Scholar
Vodermaier, A. & Millman, R.D. (2011). Accuracy of the Hospital Anxiety and Depression Scale as a screening tool in cancer patients: A systematic review and metaanalysis. Supportive Care in Cancer, 12, 1899–1908.Google Scholar
Yaskin, J. (1931). Nervous symptoms at earliest manifestations of cancer of the pancreas. The Journal of the American Medical Association, 96, 1664–1668.Google Scholar