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Prodromal depression in pancreatic cancer: Retrospective evaluation on ten patients

Published online by Cambridge University Press:  24 June 2014

Johan Sebti ,
Françoise Desseigne  and
Pierre Saltel
Johan Sebti*
Affiliation:
Department of Supportive Care, Centre Léon Bérard, Lyon, France
Françoise Desseigne
Affiliation:
Department of Digestive Oncology, Centre Léon Bérard, Lyon, France
Pierre Saltel
Affiliation:
Department of Supportive Care, Centre Léon Bérard, Lyon, France
*
Address correspondence and reprint requests to: John Sebti, 236 rue Andre Philip, 69003 Lyon, France. E-mail: [email protected]
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Abstract

Objective:

Since the description by Yaskin in 1931, it has been observed that pancreatic cancer and depression are two clinical entities that share a high affinity. This observation relies on the higher incidence of depressive syndromes associated with pancreatic cancer than in any other type of digestive tumor, and on the possible occurrence of depressive symptoms several months before the diagnosis of cancer. We present here a series of cases whose screening returned positive for depression-related diagnoses in the months prior to revelation of the cancer.

Method:

We employed a structured psychiatric interview based on DSM–IV criteria (SCID–I). The diagnoses considered were major depressive episode, minor depressive episode, and subsyndromal depression. All subjects were free of psychiatric history.

Results:

Some 15 patients were initially included: 10 presented compatible criteria for a past depressive episode, 2 presented a major depressive episode, 4 met the diagnosis of minor depression, and 4 evidenced subsyndromal depression over the one-year period prior to cancer diagnosis.

Significance of results:

This series of cases is consistent with previous work on the subject that suggested an increased vulnerability to depressive events in the premorbid phase of pancreatic cancer. If the possibility of depressive syndromes constituting the early stages of neoplastic disease is a common idea, it is still impossible to determine the natural history of these two disorders and therefore their causal linkage.

Keywords

CancerPsycho-oncologyPancreasMood disordersDepression assessment
Type
Case Report
Information
Palliative & Supportive Care , Volume 13 , Issue 3 , June 2015 , pp. 801 - 807
Copyright
Copyright © Cambridge University Press 2014 

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