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Lung cancer: Challenges and solutions for supportive care intervention research

Published online by Cambridge University Press:  28 July 2008

Penelope Schofield ,
Anna Ugalde ,
Mariko Carey ,
Linda Mileshkin ,
Mary Duffy ,
David Ball  and
Sanchia Aranda
Penelope Schofield*
Affiliation:
Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia Faculty of Medicine, Dentistry, and Health Sciences, University of Melbourne, Parkville, Victoria, Australia
Anna Ugalde
Affiliation:
Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
Mariko Carey
Affiliation:
The Cancer Council Victoria, Victoria, Australia
Linda Mileshkin
Affiliation:
Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia Faculty of Medicine, Dentistry, and Health Sciences, University of Melbourne, Parkville, Victoria, Australia
Mary Duffy
Affiliation:
Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
David Ball
Affiliation:
Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
Sanchia Aranda
Affiliation:
Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia Department of Nursing and Social Work, University of Melbourne, Parkville, Victoria, Australia
*
Address correspondence and reprint requests to: Penelope Schofield, Peter MacCallum Cancer Centre, Locked Bag 1, A'Beckett Street, Victoria, 8006, Australia. E-mail: [email protected]
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Abstract

Lung cancer is the leading cause of cancer death. It is associated with a high level of morbidity, particularly fatigue, pain, breathlessness, and coughing. These symptoms can have a substantial impact on psychosocial functioning. It is critical to have effective interventions demonstrated to improve quality of life particularly for those with advanced disease. However there is a paucity of high quality intervention research to guide practice in this area. This article discusses the challenges in conducting supportive care research in this group, including the patient's level of literacy in English, poor performance status, rapidly fluctuating health status, and familial or professional “gate-keeping.” Many of these challenges can be overcome by broadening eligibility criteria, permitting some flexibility in relation to recruitment and data collection procedures, working closely with the treatment team, involving the patient's family, minimizing practical difficulties associated with intervention delivery, and reducing study burden in other ways, such as limiting the amount of data collected from the patient and shortening follow-up time intervals. We explore these potential solutions drawing on the experience of conducting a randomized controlled trial of a support intervention for people with lung cancer and their family.

Keywords

Lung cancerSupportive careInterventionRecruitment
Type
Review Article
Information
Palliative & Supportive Care , Volume 6 , Issue 3 , September 2008 , pp. 281 - 287
Copyright
Copyright © Cambridge University Press 2008

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References

REFERENCES

Akechi, T., Okamura, H., Nishiwaki, Y., et al. (2001). Psychiatric disorders and associated and predictive factors in patients with unresectable nonsmall cell lung carcinoma: A longitudinal study. Cancer, 92, 2609–2622.3.0.CO;2-K>CrossRefGoogle ScholarPubMed
Allenby, A., Matthews, J., Beresford, J., et al. (2002). The application of computer touch-screen technology in screening for psychosocial distress in an ambulatory oncology setting. European Journal of Cancer Care, 11, 245–253.CrossRefGoogle Scholar
Australian Institute of Health and Welfare and Australasian Association of Cancer Registries (2001). Cancer Survival in Australia, 2001. Part 1: National Summary Statistics. Canberra: Australian Institute of Health and Welfare.Google Scholar
Bertram, S., Flaherty, B., & Everingham, S. (1996). Knowledge and use of alcohol and other drugs among Vietnamese-speaking migrants. Drug and Alcohol Review, 15, 121–126.CrossRefGoogle ScholarPubMed
Bredin, M., Corner, J., Krishnasamy, M., et al. (1999). Multicentre randomised controlled trial of nursing intervention for breathlessness in patients with lung cancer. British Medical Journal, 318, 901–904.CrossRefGoogle ScholarPubMed
Carlsen, K., Jensen, A.B., Jacobsen, E., et al. (2005). Psychosocial aspects of lung cancer. Lung Cancer, 43, 293–300.CrossRefGoogle Scholar
Chapple, A., Ziebland, S., & McPherson, A. (2004). Stigma, shame and blame experienced by patients with lung cancer: Qualitative study. British Journal of Medicine, 328, 1470–1475.CrossRefGoogle ScholarPubMed
Chau, I., Norman, A.R., Cunningham, D., et al. (2005). Longitudinal quality of life and quality adjusted survival in a randomised controlled trial comparing six months of bolus fluorouracil/leucovorin vs. twelve weeks of protracted venous infusion fluorouracil as adjuvant chemotherapy for colorectal cancer. European Journal of Cancer, 41, 1551–1559.CrossRefGoogle Scholar
Corner, J., Plant, H., A'Hern, R., et al. (1996). Non-pharmacological intervention for breathlessness in lung cancer. Palliative Medicine, 10, 299–305.CrossRefGoogle ScholarPubMed
Curry, C., Cossich, T., Matthews, J.P., et al. (2002). Uptake of psychosocial referrals in an outpatient cancer setting: Improving service accessibility via the referral process. Supportive Care in Cancer, 10, 549–555.CrossRefGoogle Scholar
Guerrieri, M., Wong, K., Ryan, G., et al. (2004). A randomised phase III study of palliative radiation with concomitant carboplatin for brain metastases from non-small cell carcinoma of the lung. Lung Cancer, 46, 107–111.CrossRefGoogle ScholarPubMed
Harrington, V., Lackey, N.R., & Gates, M.F. (1996). Needs of caregivers of clinic and hospice cancer patients. Cancer Nursing, 19, 118–125.CrossRefGoogle ScholarPubMed
Higgins, J.P.T. & Green, S. (2005). Cochrane Handbook for Systematic Reviews of Interventions 4.2.5. Chichester, UK: John Wiley & Sons, Ltd.Google Scholar
Hopwood, P. & Stephens, R.J. (2000). Depression in patients with lung cancer: Prevalence and risk factors derived from quality-of-life data. Journal of Clinical Oncology, 18, 893–903.CrossRefGoogle ScholarPubMed
Hudson, P., Aranda, S., & McMurray, N. (2002). Intervention development for enhanced lay palliative caregiver support—The use of focus groups. European Journal of Cancer Care, 11, 262–270.CrossRefGoogle ScholarPubMed
Krishnasamy, M. (1996). An Exploration of the Nature and Impact of Fatigue in Patients with Advanced Cancer. London: The Institute of Cancer Research.Google Scholar
Kurtz, M.E., Kurtz, J.C., Stommel, M., et al. (2002). Predictors of depressive symptomatology of geriatric patients with lung cancer—A longitudinal analysis. Psycho-Oncology, 11, 12–22.CrossRefGoogle ScholarPubMed
Lamont, E.B. & Christakis, N.A. (2001). Prognostic disclosure to patients with cancer near the end of life. Annals of Internal Medicine, 134, 1096–1105.CrossRefGoogle ScholarPubMed
McCorkle, R., Benoliel, J.Q., Donaldson, G., et al. (1989). A randomized clinical trial of home nursing care for lung cancer patients. Cancer, 64, 1375–1382.3.0.CO;2-6>CrossRefGoogle ScholarPubMed
Milne, D.J., Mulder, L.L., Beelen, H.C.M., et al. (2006). Patients' self-report and family caregivers' perception of quality of life in patients with advanced cancer: How do they compare? European Journal of Cancer Care, 15, 125–132.CrossRefGoogle ScholarPubMed
Monk, B.J., Huang, H.Q., Cella, D., et al. (2005). Quality of life outcomes from a randomized phase III trial of cisplatin with or without topotecan in advanced carcinoma of the cervix: A Gynecologic Oncology Group Study. Journal of Clinical Oncology, 23, 4617–4625.CrossRefGoogle ScholarPubMed
Moore, S., Corner, J., Haviland, J., et al. (2002). Nurse led follow up and conventional medical follow up in management of patients with lung cancer: Randomised trial. British Medical Journal, 325, 1145.CrossRefGoogle ScholarPubMed
O'Driscoll, M., Corner, J., & Bailey, C. (1999). The experience of breathlessness in lung cancer. European Journal of Cancer Care, 8, 37–43.CrossRefGoogle ScholarPubMed
Parkin, D.M., Bray, F., Ferlay, J., et al. (2005). Global cancer statistics, 2002. CA: A Cancer Journal for Clinicians, 55, 74–108.Google ScholarPubMed
Pawlikowska, T., Chalder, T., Hirsch, S.R., et al. (1994). Population based study of fatigue and psychological distress. British Medical Journal, 308, 763–766.CrossRefGoogle ScholarPubMed
Rehse, B. & Pukrop, R. (2003). Effects of psychosocial interventions on quality of life in adult cancer patients: Meta analysis of 37 published controlled outcome studies. Patient Education and Counseling, 50, 179–186.CrossRefGoogle ScholarPubMed
Ries, L.A.G., Harkins, D., Krapcho, M., et al. (2006). SEER Cancer Statistics Review, 1975–2003. http://seer.cancer.gov/csr/1975_2003/. Accessed December 20, 2006.Google Scholar
Roth, A.J. & Breitbart, W. (1996). Psychiatric emergencies in terminally ill cancer patients. Hematology/Oncology Clinics of North America, 10, 235–259.CrossRefGoogle ScholarPubMed
Sanson-Fisher, R. (2006). Challenges in quality-of-life research. Paper presented at the Clinical Oncology Society Australia (COSA), Melbourne.Google Scholar
Sarna, L. (1998). Effectiveness of structured nursing assessment of symptom distress in advanced lung cancer. Oncology Nursing Forum, 25, 1041–1048.Google ScholarPubMed
Schofield, P., Carey, M., Bonevski, B., et al. (2006). Barriers to the provision of evidence-based psychosocial care in oncology. Psycho-Oncology, 15, 863–872.CrossRefGoogle Scholar
Smith, E.L., Hann, D.M., Ahles, T.A., et al. (2001). Dyspnea, anxiety, body consciousness, and quality of life in patients with lung cancer. Journal of Pain and Symptom Management, 21, 323–329.CrossRefGoogle ScholarPubMed
Stephenson, N.L., Weinrich, S.P., & Tavakoli, A.S. (2000). The effects of foot reflexology on anxiety and pain in patients with breast and lung cancer. Oncology Nursing Forum, 27, 67–72.Google ScholarPubMed
Tanaka, K., Akechi, T., Okuyama, T., et al. (2002). Factors correlated with dyspnea in advanced lung cancer patients: Organic causes and what else? Journal of Pain and Symptom Management, 23, 490–500..CrossRefGoogle ScholarPubMed
Vena, C., Parker, K.P., Allen, R., et al. (2006). Sleep-wake disturbances and quality of life in patients with advanced lung cancer. Oncology Nursing Forum, 33, 761–769.CrossRefGoogle ScholarPubMed
Wall, L.M. (2000). Changes in hope and power in lung cancer patients who exercise. Nursing Science Quarterly, 13, 234–242.CrossRefGoogle ScholarPubMed
Wilkie, D.J., Williams, A.R., Grevstad, P., et al. (1995). Coaching persons with lung cancer to report sensory pain. Literature review and pilot study findings. Cancer Nursing, 18, 7–15.CrossRefGoogle ScholarPubMed
Zabora, J., Brintzenhofeszoc, K., Curbow, B., et al. (2001). The prevalence of psychological distress by cancer site. Psycho-Oncology, 10, 19–28.3.0.CO;2-6>CrossRefGoogle ScholarPubMed