Hostname: page-component-cd9895bd7-dk4vv Total loading time: 0 Render date: 2024-12-21T05:17:48.047Z Has data issue: false hasContentIssue false
  • English
  • Français

Facial edema as an adverse drug reaction to olanzapine in a patient with cancer receiving palliative care

Published online by Cambridge University Press:  03 March 2022

Miguel Julião Open the ORCID record for Miguel Julião [Opens in a new window] ,
Maria Ana Sobral ,
Tiago Ferreira ,
Patrícia Calaveiras ,
Elisabeth Costa ,
Ana Sara Daniel ,
Mafalda Lemos-Caldas Open the ORCID record for Mafalda Lemos-Caldas [Opens in a new window]  and
Eduardo Bruera
Miguel Julião*
Affiliation:
Equipa Comunitária de Suporte em Cuidados Paliativos de Sintra, Sintra, Portugal
Maria Ana Sobral
Affiliation:
Equipa Comunitária de Suporte em Cuidados Paliativos de Sintra, Sintra, Portugal
Tiago Ferreira
Affiliation:
Departamento de Saúde Mental, Hospital Prof. Doutor Fernando da Fonseca EPE, Amadora, Portugal
Patrícia Calaveiras
Affiliation:
Equipa Comunitária de Suporte em Cuidados Paliativos de Sintra, Sintra, Portugal
Elisabeth Costa
Affiliation:
Equipa Comunitária de Suporte em Cuidados Paliativos de Sintra, Sintra, Portugal
Ana Sara Daniel
Affiliation:
Equipa Comunitária de Suporte em Cuidados Paliativos de Sintra, Sintra, Portugal
Mafalda Lemos-Caldas
Affiliation:
ACeS Loures-Odivelas, USF Travessa da Saúde, Lisboa, Portugal
Eduardo Bruera
Affiliation:
Department of Palliative, Rehabilitation and Integrative Medicine, University of Texas MD Anderson Cancer Center, Houston, TX
*
Author for correspondence: Miguel Julião, Equipa Comunitária de Suporte em Cuidados Paliativos de Sintra 2635-364 Rio de Mouro, Sintra, Portugal. E-mail: [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

Objective

Atypical neuroleptics such as olanzapine are indicated for the treatment of various psychiatric disorders and have been used in the palliative care setting also for several clinical indications. Peripheral and facial edema are a rare side effect of the treatment with olanzapine. We report a case of an advanced cancer patient cared receiving palliative care who developed severe facial edema after initiating a low dose of olanzapine in monotherapy.

Method

A patient with advanced cancer who presented with severe facial edema after initiating olanzapine for the treatment of her opioid use disorder.

Results

After excluding other differential diagnosis for facial edema, olanzapine was discontinued with complete resolution of the edema.

Significance of results

To the best of our knowledge, this is the first case reporting facial edema due to olanzapine treatment in a patient with advanced cancer. Our report will help clinicians recognize the possible role of olanzapine in cases of rapid onset of facial edema, allowing its rapid resolution.

Keywords

CancerCase reportFacial edemaOlanzapinePalliative careTerminally ill
Type
Case Report
Information
Palliative & Supportive Care , Volume 20 , Issue 5 , October 2022 , pp. 752 - 753
Copyright
Copyright © The Author(s), 2022. Published by Cambridge University Press

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Akin, S, Bahat, G, Tufan, F, et al. (2013) Olanzapine as a cause of peripheric edema in an elderly man. Aging Clinical and Experimental Research 25, 115–117.CrossRefGoogle Scholar
Deshauer, D, Ervin, L and Karagianis, J (2006) Case report: Edema related to olanzapine therapy. Canadian Family Physician 52, 620–621.Google ScholarPubMed
Durst, R, Raskin, S, Katz, G, et al. (2000) Pedal edema associated with clozapine use. IMAJ 2, 485–486.Google ScholarPubMed
Go, SI, Song, HN, Lee, SJ, et al. (2018) Craving behavior from opioid addiction controlled with olanzapine in an advanced cancer patient: A case report. Journal of Palliative Medicine 21(9), 1367–1370.CrossRefGoogle Scholar
Han Almiş, B and Çeli, M (2017) Facial edema after olanzapine addition to sertraline: A case report. Alpha Psychiatry 18(Supplement), 46–47.Google Scholar
Julião, M, Lemos-Caldas, M, Ulrich, J, et al. (2021) The use of olanzapine for nonmedical opioid use in a patient with cancer receiving palliative care. Journal of Palliative Medicine (Accepted for publication).Google Scholar
Korkmaz, S, Baykara, S, Özer, Ö, et al. (2015) Facial edema that develops with olanzapine. Journal of Advances in Medical and Pharmaceutical Sciences 4(3), 1–4.CrossRefGoogle Scholar
Malhotra, M and Shrivastava, MK (2013) Facial edema with olanzapine. General Hospital Psychiatry 35(6), 682.e7–682.e8.CrossRefGoogle ScholarPubMed
Meulendijks, D, Mannesse, CK, Jansen, PA, et al. (2010) Antipsychotic-induced hyponatremia: A systematic review of the published evidence. Drug Safety 33, 101–114.CrossRefGoogle ScholarPubMed
Naranjo, CA, Busto, U, Sellers, EM, et al. (1981) A method for estimating the probability of adverse drug reactions. Clinical Pharmacology and Therapeutics 30, 239–245.CrossRefGoogle ScholarPubMed
Nayak, V, Chogtu, B, Devaramane, V, et al. (2009) Pedal edema with olanzapine. Indian Journal of Pharmacology 41, 49–50.CrossRefGoogle Scholar
Ng, B, Postlethwaite, A and Rollnik, J (2003) Peripheral oedema in patients taking olanzapine. International Clinical Psychopharmacology 18(1), 57–59.Google ScholarPubMed
Williams, GD (2019) Cross-reaction of angioedema with clozapine, olanzapine, and quetiapine: A case report. Mental Health Clinician 9(5), 315–317.CrossRefGoogle ScholarPubMed
Yalug, I, Osten, E, Tufan, AE, et al. (2007) Bilateral pedal edema associated with olanzapine use in manic episode of bipolar disorder. Progress in Neuro-Psychopharmacology & Biological Psychiatry 31, 1541–1542.CrossRefGoogle ScholarPubMed
Zinh, M, Kuwilsky, A and Knopf, U (2007) Olanzapine associated bilateral eyelid edema. Journal of Clinical Psychopharmacology 22, 214–215.Google Scholar