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Nutrition and sarcopenia of ageing

Published online by Cambridge University Press:  14 December 2007

Satoshi Fujita  and
Elena Volpi
Satoshi Fujita
Affiliation:
Department of Medicine, Division of Endocrinology and Diabetes, University of Southern California, 1333 San Pablo Street, BMT-B11, Los Angeles, CA 90033, USA
Elena Volpi*
Affiliation:
Department of Medicine, Division of Endocrinology and Diabetes, University of Southern California, 1333 San Pablo Street, BMT-B11, Los Angeles, CA 90033, USA
*
*Corresponding author: Dr Elena Volpi, fax +1 323 442 2809, email [email protected]
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Abstract

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Sarcopenia, the loss of muscle mass and function with ageing, is a multifactorial condition that slowly develops over decades and becomes a significant contributor to disability in the older population. Malnutrition and alterations in the muscle anabolic response to nutritional stimuli have been identified as potentially preventable factors that may significantly contribute to sarcopenia. In the present article we review the most recent findings regarding the role of nutritional factors in the development, prevention and treatment of sarcopenia. Specifically, we focus on the nutritional needs of the elderly; the age-related changes in the response of muscle protein metabolism to feeding and to the endogenous hormones released during feeding; and the role played by the splanchnic tissues in the response of muscle proteins to feeding. Finally, we review the issues relative to the potential use of nutritional therapies, including supplementation, for the prevention and treatment of sarcopenia.

Keywords

AgeingSarcopeniaProtein metabolism
Type
Research Article
Information
Nutrition Research Reviews , Volume 17 , Issue 1 , June 2004 , pp. 69 - 76
Copyright
Copyright © The Authors 2004

References

Allen, RE & Rankin, LL (1990) Regulation of satellite cells during skeletal muscle growth and development. Proceedings of the Society for Experimental Biology and Medicine 194, 81–86.CrossRefGoogle ScholarPubMed
Anthony, JC, Reiter, AK, Anthony, TG, Crozier, SJ, Lang, CH, MacLean, DA, Kimball, SR & Jefferson, LS (2002) Orally administered leucine enhances protein synthesis in skeletal muscle of diabetic rats in the absence of increases in 4E–BP1 or S6K1 phosphorylation. Diabetes 51, 928–936.CrossRefGoogle ScholarPubMed
Anthony, JC, Yoshizawa, F, Anthony, TG, Vary, TC, Jefferson, LS & Kimball, SR (2000) Leucine stimulates translation initiation in skeletal muscle of postabsorptive rats via a rapamycin–sensitive pathway. Journal of Nutrition 130, 2413–2419.CrossRefGoogle Scholar
Arnal, MA, Mosoni, L, Boirie, Y, Houlier, ML, Morin, L, Verdier, E, Ritz, P, Antoine, JM, Prugnaud, J, Beaufrere, B & Mirand, PP (1999) Protein pulse feeding improves protein retention in elderly women. American Journal of Clinical Nutrition 69, 1202–1208.CrossRefGoogle ScholarPubMed
Arnal, MA, Mosoni, L, Boirie, Y, Houlier, ML, Morin, L, Verdier, E, Ritz, P, Antoine, JM, Prugnaud, J, Beaufrere, B & Mirand, PP (2000) Protein feeding pattern does not affect protein retention in young women. Journal of Nutrition 130, 1700–1704.Google Scholar
Balagopal, P, Rooyackers, OE, Adey, DB, Ades, PA & Nair, KS (1997) Effects of aging on in vivo synthesis of skeletal muscle myosin heavy–chain and sarcoplasmic protein in humans. American Journal of Physiology 273, E790–E800.Google ScholarPubMed
Biolo, G, Fleming, RY, Maggi, SP & Wolfe, RR (1995) Transmembrane transport and intracellular kinetics of amino acids in human skeletal muscle. American Journal of Physiology 268, E75–E84.Google ScholarPubMed
Biolo, G, Tipton, KD, Klein, S & Wolfe, RR (1997) An abundant supply of amino acids enhances the metabolic effect of exercise on muscle protein. American Journal of Physiology 273, E122–E129.Google ScholarPubMed
Boirie, Y, Dangin, M, Gachon, P, Vasson, MP, Maubois, JL & Beaufrere, B (1997 a) Slow and fast dietary proteins differently modulate postprandial protein accretion. Proceedings of the National Academy of Sciences USA 94, 14930–14935.CrossRefGoogle ScholarPubMed
Boirie, Y, Gachon, P & Beaufrere, B (1997 b) Splanchnic and whole–body leucine kinetics in young and elderly men. American Journal of Clinical Nutrition 65, 489–495.CrossRefGoogle Scholar
Buse, MG & Reid, SS (1975) Leucine: a possible regulator of protein turnover in muscle. Journal of Clinical Investigation 56, 1250–1261.CrossRefGoogle ScholarPubMed
Campbell, WW, Crim, MC, Dallal, GE, Young, VR & Evans, WJ (1994) Increased protein requirements in elderly people: new data and retrospective reassessments. American Journal of Clinical Nutrition 60, 501–509.CrossRefGoogle ScholarPubMed
Campbell, WW, Crim, MC, Young, VR, Joseph, LJ & Evans, WJ (1995) Effects of resistance training and dietary protein intake on protein metabolism in older adults. American Journal of Physiology 268, E1143–E1153.Google ScholarPubMed
Campbell, WW, Trappe, TA, Wolfe, RR & Evans, WJ (2001) The recommended dietary allowance for protein may not be adequate for older people to maintain skeletal muscle. Journals of Gerontology 56A, M373–M380.Google Scholar
Cortopassi, GA, Shibata, D, Soong, NW & Arnheim, N (1992) A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues. Proceedings of the National Academy of Sciences USA 89, 7370–7374.CrossRefGoogle ScholarPubMed
Dangin, M, Boirie, Y, Garcia-Rodenas, C, Gachon, P, Fauquant, J, Callier, P, Ballevre, O & Beaufrere, B (2001) The digestion rate of protein is an independent regulating factor of postprandial protein retention. American Journal of Physiology 280, E340–E348.Google ScholarPubMed
Dangin, M, Boirie, Y, Guillet, C & Beaufrere, B (2002) Influence of the protein digestion rate on protein turnover in young and elderly subjects. Journal of Nutrition 132, 3228S–3233S.CrossRefGoogle Scholar
Dutta, C & Hadley, EC (1995) The significance of sarcopenia in old age. Journals of Gerontology 50A, 1–4.Google Scholar
Evans, WJ (1995) What is sarcopenia? Journals of Gerontology 50A, 5–8.Google Scholar
Fiatarone, MA, O'Neill, EF, Ryan, ND, Clements, KM, Solares, GR, Nelson, ME, Roberts, SB, Kehayias, JJ, Lipsitz, LA & Evans, WJ (1994) Exercise training and nutritional supplementation for physical frailty in very elderly people. New England Journal of Medicine 330, 1769–1775.CrossRefGoogle ScholarPubMed
Food and Nutrition Board and Institute of Medicine (2002) Protein and amino acids. In Dietary Reference Intakes for Energy, Carbohydrates, Fiber, Fat, Protein and Amino Acids pp. 465–608 [Institute of Medicine editor]. Washington DC: The National Academies Press.Google Scholar
Garlick, PJ & Grant, I (1988) Amino acid infusion increases the sensitivity of muscle protein synthesis in vivo to insulin. Effect of branched–chain amino acids. Biochemical Journal 254, 579–584.CrossRefGoogle ScholarPubMed
Hasten, DL, Pak-Loduca, J, Obert, KA & Yarasheski, KE (2000) Resistance exercise acutely increases MHC and mixed muscle protein synthesis rates in 78–84 and 23–32 yr olds. American Journal of Physiology 278, E620–E626.Google ScholarPubMed
Holloszy, JO (2000) The biology of aging. Mayo Clinic Proceedings 75, Suppl., S3–S8.CrossRefGoogle ScholarPubMed
Kelijman, M (1991) Age–related alterations of the growth hormone/insulin–like–growth–factor I axis. Journal of the American Geriatrics Society 39, 295–307.CrossRefGoogle ScholarPubMed
Lexell, J (1995) Human aging, muscle mass, and fiber type composition. Journals of Gerontology 50A, 11–16.Google Scholar
Li, JB & Jefferson, LS (1978) Influence of amino acid availability on protein turnover in perfused skeletal muscle. Biochimica Biophysica Acta 544, 351–359.CrossRefGoogle ScholarPubMed
McCormick, KM & Thomas, DP (1992) Exercise–induced satellite cell activation in senescent soleus muscle. Journal of Applied Physiology 72, 888–893.CrossRefGoogle ScholarPubMed
McDowell, MA, Briefel, RR, Alaimo, K, Bischof, AM, Caughman, CR, Carroll, MD, Loria, CM & Johnson, CL (1994) Energy and Macronutrient Intakes of Persons Aged 2 Months and Over in the United States: Third National Health and Nutrition Examination Survey, Phase 1, 1988–91. Hyattsville, MD: National Center for Health Statistics.Google ScholarPubMed
Matthews, DE, Marano, MA & Campbell, RG (1993) Splanchnic bed utilization of leucine and phenylalanine in humans. American Journal of Physiology 264, E109–E118.Google ScholarPubMed
Melton, LJ III, Khosla, S, Crowson, CS, O'Connor, MK, O'Fallon, WM & Riggs, BL (2000) Epidemiology of sarcopenia. Journal of the American Geriatrics Society 48, 625–630.Google ScholarPubMed
Morley, JE (1997) Anorexia of aging: physiologic and pathologic. American Journal of Clinical Nutrition 66, 760–773.CrossRefGoogle ScholarPubMed
Mosoni, L, Valluy, MC, Serrurier, B, Prugnaud, J, Obled, C, Guezennec, CY & Mirand, PP (1995) Altered response of protein synthesis to nutritional state and endurance training in old rats. American Journal of Physiology 268, E328–E335.Google ScholarPubMed
Rasmussen, BB, Wolfe, RR & Volpi, E (2002) Oral and intravenously administered amino acids produce similar effects on muscle protein synthesis in the elderly. Journal of Nutrition, Health and Aging 6, 358–362.Google ScholarPubMed
Reeds, PJ, Fjeld, CR & Jahoor, F (1994) Do the differences between the amino acid compositions of acute–phase and muscle proteins have a bearing on nitrogen loss in traumatic states? Journal of Nutrition 124, 906–910.CrossRefGoogle ScholarPubMed
Rennie, MJ, Edwards, RHT, Halliday, D, Matthews, DE, Wolman, SL & Millward, DJ (1982) Muscle protein synthesis measured by stable isotope techniques in man: the effects of feeding and fasting. Clinical Science 63, 519–523.CrossRefGoogle ScholarPubMed
Roubenoff, R (1993) Hormones, cytokines and body composition: can lessons from illness be applied to aging? Journal of Nutrition 123, Suppl., 469–473.CrossRefGoogle ScholarPubMed
Roubenoff, R & Castaneda, C (2001) Sarcopenia – understanding the dynamics of aging muscle. Journal of the American Medical Association 286, 1230–1231.CrossRefGoogle ScholarPubMed
Roubenoff, R, Rall, LC, Veldhuis, JD, Kehayias, JJ, Rosen, C, Nicolson, M, Lundgren, N & Reichlin, S (1998) The relationship between growth hormone kinetics and sarcopenia in postmenopausal women: the role of fat mass and leptin. Journal of Clinical Endocrinology and Metabolism 83, 1502–1506.Google ScholarPubMed
Smith, K, Barua, JM, Watt, PW, Scrimgeour, CM & Rennie, MJ (1992) Flooding with [1– 13 C]leucine stimulates human muscle protein incorporation of continuously infused L–[1– 13 C]valine. American Journal of Physiology 262, E372–E376.Google Scholar
Smith, K, Reynolds, N, Downie, S, Patel, A & Rennie, MJ (1998) Effects of flooding amino acids on incorporation of labeled amino acids into human muscle protein. American Journal of Physiology 275, E73–E78.Google ScholarPubMed
Tenover, JS (1992) Effects of testosterone supplementation in the aging male. Journal of Clinical Endocrinology and Metabolism 75, 1092–1098.Google ScholarPubMed
Tenover, JS, Matsumoto, AM, Clifton, DK & Bremner, WJ (1988) Age–related alterations in the circadian rhythms of pulsatile luteinizing hormone and testosterone secretion in healthy men. Journal of Gerontology 43, M163–M169.CrossRefGoogle ScholarPubMed
Tinetti, ME & Williams, CS (1997) Falls, injuries due to falls, and the risk of admission to a nursing home. New England Journal of Medicine 337, 1279–1284.CrossRefGoogle ScholarPubMed
Toffolo, G, Foster, DM & Cobelli, C (1993) Estimation of protein fractional synthetic rate from tracer data. American Journal of Physiology 264, E128–E135.Google ScholarPubMed
Volpi, E, Ferrando, AA, Yeckel, CW, Tipton, KD & Wolfe, RR (1998) Exogenous amino acids stimulate net muscle protein synthesis in the elderly. Journal of Clinical Investigation 101, 2000–2007.CrossRefGoogle ScholarPubMed
Volpi, E, Kobayashi, H, Sheffield-Moore, M, Mittendorfer, B & Wolfe, RR (2003) Essential amino acids are primarily responsible for the amino acid stimulation of muscle protein anabolism in healthy elderly adults. American Journal of Clinical Nutrition 78, 250–258.CrossRefGoogle ScholarPubMed
Volpi, E, Mittendorfer, B, Rasmussen, BB & Wolfe, RR (2000) The response of muscle protein anabolism to combined hyperaminoacidemia and glucose–induced hyperinsulinemia is impaired in the elderly. Journal of Clinical Endocrinology and Metabolism 85, 4481–4490.Google ScholarPubMed
Volpi, E, Mittendorfer, B, Wolf, SE & Wolfe, RR (1999) Oral amino acids stimulate muscle protein anabolism in the elderly despite higher first pass splanchnic extraction. American Journal of Physiology 277, E513–E520.Google ScholarPubMed
Volpi, E, Sheffield-Moore, M, Rasmussen, BB & Wolfe, RR (2001) Basal muscle amino acid kinetics and protein synthesis in healthy young and older men. Journal of the American Medical Association 286, 1206–1212.CrossRefGoogle Scholar
Welle, S & Nair, KS (1990) Relationship of resting metabolic rate to body composition and protein turnover. American Journal of Physiology 258, E990–E998.Google ScholarPubMed
Welle, S, Thornton, C, Jozefowicz, R & Statt, M (1993) Myofibrillar protein synthesis in young and old men. American Journal of Physiology 264, E693–E698.Google Scholar
Welle, S, Thornton, C & Statt, M (1995) Myofibrillar protein synthesis in young and old human subjects after three months of resistance training. American Journal of Physiology 268, E422–E427.Google Scholar
Welle, S & Thornton, CA (1998) High–protein meals do not enhance myofibrillar synthesis after resistance exercise in 62– to 75–yr–old men and women. American Journal of Physiology 274, E677–E683.Google Scholar
Wolfe, RR & Volpi, E (2000) Insulin and protein metabolism. In The Endocrine Pancreas and Regulation of Metabolism. vol. II, pp. 733–755 [Jefferson, LS and Cherrington, AD editors]. New York: Oxford University Press.Google Scholar
Wolfson, L, Judge, J, Whipple, R & King, M (1995) Strength is a major factor in balance, gait, and the occurrence of falls. Journals of Gerontology 50A, 64–67.Google Scholar
Yarasheski, KE, Zachwieja, JJ & Bier, DM (1993) Acute effects of resistance exercise on muscle protein synthesis rate in young and elderly men and women. American Journal of Physiology 265, E210–E214.Google Scholar
Young, VR (1990) Amino acids and proteins in relation to the nutrition of elderly people. Age and Ageing 19, S10–S24.CrossRefGoogle Scholar