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Human Amino Acid and Protein Requirements: Current Dilemmas and Uncertainties

Published online by Cambridge University Press:  14 December 2007

D. J. Millward ,
A. A. Jackson ,
Gillian Price  and
J. P. W. Rivers
D. J. Millward
Affiliation:
Nutrition Research Unit, London School of Hygiene and Tropical Medicine, 4 St Pancras Way, London NW1 2PE
A. A. Jackson
Affiliation:
Department of Human Nutrition, University of Southampton, Bassett Crescent East, Southampton, SO9 3TU
Gillian Price
Affiliation:
Nutrition Research Unit, London School of Hygiene and Tropical Medicine, 4 St Pancras Way, London NW1 2PE
J. P. W. Rivers
Affiliation:
Nutrition Research Unit, London School of Hygiene and Tropical Medicine, 4 St Pancras Way, London NW1 2PE
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Abstract

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Type
Research Article
Information
Nutrition Research Reviews , Volume 2 , Issue 1 , January 1989 , pp. 109 - 132
Copyright
Copyright © The Nutrition Society 1989

References

REFERENCES

Adibi, S. A., Fekl, W., Fürst, P. & Oehmke, M. (editors) (1987). In Dipeptides As New Substrates in Nutrition Therapy. Munich: Karger.Google Scholar
Askanazi, J., Carpentier, Y. A., Michelsen, C. B., Elwyn, D. H., Furst, P., Kantrowitz, L. R., Gump, F. E. & Kinney, J. M. (1980). Muscle and plasma amino acids following injury. Annals of Surgery 192, 78–85.CrossRefGoogle ScholarPubMed
Atinmo, T., Mbofung, C. M. F., Egun, G. & Osotimehin, B. (1988). Nitrogen balance study in young Nigerian male adults using four levels of protein intake. British Journal of Nutrition 60, 451–458.CrossRefGoogle ScholarPubMed
Atinmo, T., Mbofung, C. M. F., Hussain, M. A. & Osotimehin, B. O. (1985). Human protein requirements: obligatory urinary and faecal nitrogen losses and the factorial estimation of protein needs of Nigerian male adults. British Journal of Nutrition 54, 605–611.CrossRefGoogle ScholarPubMed
Beaton, G. H. & Chery, A. (1988). Protein requirements of infants: a reexamination of concepts and approaches. American Journal of Clinical Nutrition 48, 1403–1412.CrossRefGoogle Scholar
Beggs, M., Espinal, J., Patel, H. & Randle, P. J. (1986). Effects of low-protein diet and starvation on the activity of branched-chain 2-oxoacid dehydrogenase kinase. Biochemical Society Transactions 14, 1055–1056.CrossRefGoogle Scholar
Blaxter, K. L. & Waterlow, J. C. (editors) (1985). Nutritional Adaptation in Man. London: John Libbey.Google Scholar
Buss, D. H. & Ruck, N. (1977). The amino acid pattern of the British diet. Journal of Human Nutrition 31, 165–169.Google ScholarPubMed
Calloway, D. H. (1981). Energy-protein relationships. In Protein Quality in Humans: Assessment and in vitro Estimation, pp. 148–168 [Bodwell, C. E., Atkins, J. S. and Hopkins, D. T. editors]. Westport, Connecticut: AVI.Google Scholar
Calloway, D. H. & Spector, H. (1954). Nitrogen balance as related to caloric and protein intake in active young men. American Journal of Clinical Nutrition 2, 405–409.CrossRefGoogle ScholarPubMed
Catzeflis, C., Schutz, Y., Micheli, J. -L., Welsch, C., Arnaud, M. J. & Jequier, E. (1985). Whole body protein synthesis and energy expenditure in very low birth weight infants. Pediatric Research 19, 679.CrossRefGoogle ScholarPubMed
De Benoist, B., Abdulrazzak, Y., Brooke, O. G., Halliday, D. & Millward, D. J. (1984). The measurement of whole body protein turnover in the preterm infant with intragastric infusion of L-[1-13C]leucine and sampling of the urinary leucine pool. Clinical Science 66, 155–164.CrossRefGoogle ScholarPubMed
Doherty, T., De Benoist, M. H., Hibbert, J., Persaud, C. & Jackson, A. A. (1989). The effect of the level of dietary protein and the quality of dietary energy on urea kinetics in young children recovering from severe malnutrition. Proceedings of the Nutrition Society 48, 55A.Google Scholar
Durkin, N., Ogar, D. A., Tilve, S. G. & Margen, S. (1981). Human protein requirements. Autocorrelation and adaptation to a low-protein diet containing. 356 gm protein/kg or 57 mg N/kg body weight. FAO/WHO/UNU Information paper no. 7. Geneva: WHO.Google Scholar
Fomon, S. J. (1986). Protein requirements of term infants. In Energy and protein Needs During Infancy, pp. 55–68 [Fomon, S. J. and Heird, W. C. editors]. New York: Academic Press.Google Scholar
Fomon, S. J., Filer, L. J., Zeigler, E. E., Bergman, K. E. & Bergmann, R. L. (1977). Skim milk in infant feeding. Acta Paediatrica Scandinavica 66, 17–30.CrossRefGoogle ScholarPubMed
Fomon, S. J., Matthews, D. E., Bier, D. M., Rogers, R. R., Rebouche, C. J., Edwards, B. B. & Nelson, S. E. (1987). Bioavailability of dietary urea nitrogen in the infant. Journal of Pediatrics 111, 221–224.CrossRefGoogle ScholarPubMed
Food and Agriculture Organization/World Health Organization (1973). Energy and Protein Requirements. Report of a Joint FAO/WHO ad hoc Expert Committee. Technical Report Series no. 52 Geneva: WHO.Google Scholar
Food and Agriculture Organization/World Health Organization/United Nations University (1985). Energy and Protein Requirements. Report of a Joint Expert Consultation. WHO Technical Report Series no. 724. Geneva: WHO.Google Scholar
Fürst, P., Elwyn, D. H., Askanazi, J. & Kinney, J. M. (1982). Effects of nutrition and catabolic stress on intracellular branched-chain amino acids. In Clinical Nutrition '81, pp. 10–17. Edinburgh: Churchill Livingstone.Google Scholar
Garza, C., Scrimshaw, N. S. & Young, V. R. (1977). Human protein requirements: a long-term metabolic nitrogen balance study in young men to evaluate the 1973 FAO/WHO safe level of egg protein intake. Journal of Nutrition 107, 335–352.CrossRefGoogle Scholar
Golden, M. H. N., Waterlow, J. C. & Picou, D. (1977). Protein turnover, synthesis and breakdown before and after recovery from protein–energy malnutrition. Clinical Science and Molecular Medicine 53, 473–477.Google ScholarPubMed
Gopalan, C. & Rao, Narasinga V. S. (1966). Effect of protein depletion on urinary nitrogen excretion in undernourished subjects. Journal of Nutrition 90, 213–218.CrossRefGoogle ScholarPubMed
Graham, G. G., Cordano, A., Blizzard, R. M. & Cheek, D. B. (1969). Infantile malnutrition: changes in body composition during rehabilitation. Pediatric Research 3, 579–589.CrossRefGoogle ScholarPubMed
Harzer, G., Franzke, V. & Bindels, J. G. (1984). Human milk nonprotein nitrogen components: changing patterns of free amino acids and urea in the course of early lactation. American Journal of Clinical Nutrition 40, 303–309.CrossRefGoogle ScholarPubMed
Hegsted, D. M. (1976). Balance studies. Journal of Nutrition 106, 307–311.CrossRefGoogle Scholar
Heine, W., Tiess, M., Stolpe, H. J. & Wutzke, K. (1984). Urea utilisation by the intestinal flora, of infants fed mother's milk and as a formula diet, as measured with the 15N-tracer technique. Journal of Pediatric Gastroenterology and Nutrition 3, 709–712.Google ScholarPubMed
Heine, W., Tiess, M. & Wutzke, K. D. (1986). 15N-tracer investigation of the physiological availability of urea nitrogen in mother's milk. Acta Pediatrica Scandinavica 75, 539.CrossRefGoogle Scholar
Heine, W., Wutzke, K. D., Richter, I., Walther, F. & Plath, C. (1987). Evidence for colonic absorption of protein nitrogen in infants. Acta Pediatrica Scandinavica 76, 741–744.CrossRefGoogle ScholarPubMed
Huang, P. C. & Lin, C. P. (1982). Protein requirements of young Chinese male adults on ordinary Chinese mixed diet and egg diet at ordinary levels of energy intake. Journal of Nutrition 112, 897–907.CrossRefGoogle ScholarPubMed
Inoue, G., Fujita, Y., Kishi, K., Yamamoto, S. & Niiyama, Y. (1974). Nutritive values of egg protein and wheat gluten in young men. Nutrition Reports International 10, 201–207.Google Scholar
Jackson, A. A. (1983). Amino acids: essential and non-essential. Lancet i, 1034–1037.CrossRefGoogle Scholar
Jackson, A. A. (1989). Optimising amino acid and protein supply and utilisation in the newborn. Proceedings of the Nutrition Society 48, 189–197.CrossRefGoogle Scholar
Jackson, A. A., Badaloo, A. V., Forrester, T., Hibbert, J. M. & Persaud, C. (1987). Urinary excretion of 5-oxoproline (pyroglutamic aciduria) as an index of glycine insufficiency in normal man. British Journal of Nutrition 58, 207–214.CrossRefGoogle ScholarPubMed
Jackson, A. A. & Golden, M. H. N. (1980). 15N-glycine metabolism in normal man: the metabolic α-amino nitrogen pool. Clinical Science 58, 517–522.CrossRefGoogle Scholar
Jackson, A. A. & Grimble, R. F. (1989). Malnutriton and amino acid metabolism. In The Malnourished Child, 19th Nestlé Nutrition Workshop [Suskind, R. editor]. New York: Raven Press.Google Scholar
Jackson, A. A., Landman, J. P., Stevens, M. C. G. & Serjeant, G. R. (1988). Urea kinetics in adults with homozygous sickle cell disease. European Journal of Clinical Nutrition 42, 491–496.Google ScholarPubMed
Jackson, A. A., Shaw, J. C. L., Barber, A. & Golden, M. H. N. (1981). Nitrogen metabolism in preterm infants fed human donor breast milk: the possible essentiality of glycine. Pediatric Research 15, 1454–1461.CrossRefGoogle ScholarPubMed
Jahoor, F., Jackson, A. A. & Golden, M. H. N. (1988). In vivo metabolism of nitrogen precursors for urea synthesis in the postprandrial rat. Annals of Nutrition and Metabolism 32, 240–244.CrossRefGoogle Scholar
Jeejeebhoy, K. N. (1986). Nutritional balance studies: indicators of human requirements or adaptive mechanisms. Journal of Nutrition 116, 2061–2063.CrossRefGoogle ScholarPubMed
Jepson, M. M., Bates, P. C., Broadbent, P., Pell, J. M. & Millward, D. J. (1988). Relationship between glutamine concentration and protein synthesis in rat skeletal muscle. American Journal of Physiology 255, E166–E172.Google ScholarPubMed
Kapadia, C. R., Colpoys, M. F., Jiang, Z.-M., Johnson, D. J., Smith, R. J. & Wilmore, D. W. (1985). Maintenance of skeletal muscle intracellular glutamine during standard surgical trauma. Journal of Parenteral & Enteral Nutrition 9, 583–589.CrossRefGoogle ScholarPubMed
Kies, C. (1972). Nonspecific nitrogen in the nutrition of human beings. Federation Proceedings 31, 1172–1177.Google ScholarPubMed
Kishi, K., Miyatani, S. & Inoue, G. (1978). Requirement and utilization of egg protein by Japanese young men with marginal intakes of energy. Journal of Nutrition 108, 658–669.CrossRefGoogle ScholarPubMed
Laidlaw, S. A. & Kopple, J. D. (1987). Newer concepts of the indispensable amino acids. American Journal of Clinical Nutrition 46, 593–605.CrossRefGoogle ScholarPubMed
McIntosh, N., Shaw, J. C. L. & Taghizadeh, A. (1977). Accumulation of nitrogen and collagen in the femur of the human foetus and the effect of premature birth. Pediatric Research 11, 1023–1028.Google Scholar
MacLennon, P. A., Brown, R. A. & Rennie, M. J. (1987). A positive relationship between protein synthetic rate and intracellular glutamine concentration in perfused rat skeletal muscle. FEBS Letters 215, 187–191.CrossRefGoogle Scholar
MacLennon, P. A., Smith, K., Weryk, B., Watt, P. W. & Rennie, M. J. (1988). FEBS Letters 237, 133–136.CrossRefGoogle Scholar
Meguid, M. M., Matthews, D. E., Bier, D. M., Meredith, C. N., Soeldner, J. S. & Young, V. R. (1986). Leucine kinetics at graded leucine intakes in young men. American Journal of Clinical Nutrition 43, 770–780.CrossRefGoogle ScholarPubMed
Millward, D. J. (1980). Protein turnover in skeletal and cardiac muscle during normal growth and hypertrophy. In Degradative Processes in Heart and Skeletal Muscle, pp. 161–199 [Wildenthal, K. editor]. Amsterdam: Elsevier/North-Holland.Google Scholar
Millward, D. J. (1989 a). Protein requirements of infants. American Journal of Clinical Nutrition 50, 406–407.CrossRefGoogle ScholarPubMed
Millward, D. J. (1989 b). The endocrine response to dietary protein: the anabolic drive on growth. In Milk Proteins in Human Nutrition, pp. 49–61 [Barth, C. A. and Schlimme, E. editors]. Darmstadt: Steinkopff.CrossRefGoogle Scholar
Millward, D. J., Davies, C. T. M., Halliday, D., Wolman, S. L., Matthews, D. & Rennie, M. J. (1982). The effect of exercise on protein metabolism in man as explored with stable isotopes. Federation Proceedings 41, 2686–2691.Google Scholar
Millward, D. J. & Rivers, J. P. W. (1988). The nutritional role of indispensable amino acids and the metabolic basis for their requirements. European Journal of Clinical Nutrition 42, 367–393.Google ScholarPubMed
Millward, D. J. & Rivers, J. P. W. (1989). The need for indispensable amino acids: the concept of the anabolic drive. Diabetes-Metabolism Reviews 5, 191–210.CrossRefGoogle ScholarPubMed
Moran, B., Persaud, C. & Jackson, A. A. (1989). Urea absorption by the functioning human colon. Proceedings of the Nutrition Society 48, 75A.Google Scholar
Muhlbacher, F., Kapadia, Raja C., Colpoys, M., Smith, R. J. & Wilmore, D. W. (1984). Effects of glucocorticoids on glutamine metabolism in skeletal muscle. American Journal of Physiology 247, E75–E83.Google ScholarPubMed
Munro, H. N. (1985). Historical perspective on protein requirements: objectives for the future. In Nutritional Adaptation in Man, pp. 155–168 [Blaxter, K. and Waterlow, J. C. editors]. London and Paris: John Libbey.Google Scholar
Newsholme, E. A., Crabtree, B. & Ardawi, M. S. M. (1985). Glutamine metabolism in lymphocytes: its biochemical, physiological and clinical importance. Quarterly Journal of Experimental Physiology 700, 473–489.CrossRefGoogle Scholar
Nicol, B. M. & Phillips, P. G. (1976 a). Endogenous nitrogen excretion and utilization of dietary protein. British Journal of Nutrition 35, 181–193.CrossRefGoogle ScholarPubMed
Nicol, B. M. & Phillips, P. G. (1976 b). The utilization of dietary protein by Nigerian men. British Journal of Nutrition 36, 337–351.CrossRefGoogle ScholarPubMed
Nissim, I., Yudkoff, M., Yang, W., Terwilliger, T. & Segal, S. (1981). Rapid gas chromatographic-mass spectrometric analysis of 15N urea:application to human metabolic studies. Clinica Chemica Acta 109, 295–304.CrossRefGoogle ScholarPubMed
Pellett, P. L. & Young, V. R. (1988). Protein and amino acid needs for adults. Ecology of Food and Nutrition 21, 321–330.CrossRefGoogle Scholar
Pencharz, P. B., Farri, L. & Papageorgiou, A. (1983). The effects of human milk and low protein formulae on the rates of total body protein turnover and urinary 3-methylhistidine excretion of preterm infants. Clinical Science and Molecular Medicine 64, 611–616.Google ScholarPubMed
Persaud, C., Forrester, T. & Jackson, A. A. (1987). Glycine: limiting amino acid for rapid growth. Proceedings of the Nutrition Society 46, 136A.Google Scholar
Persaud, C., McDermott, J., DeBenoist, B. & Jackson, A. A. (1989). The excretion of 5-oxoproline in urine as an index of glycine status during normal pregnancy. British Journal of Obstetrics and Gynaecology 96, 440–444.CrossRefGoogle ScholarPubMed
Rand, W. M., Scrimshaw, N. S. & Young, V. R. (1981). Conventional long term nitrogen balance studies for protein quality evaluation in adults: rationale and limitations. In Protein Quality in Humans: Assessment and in vitro Estimation, pp. 59–97 [Bodwell, C. E., Atkins, J. S. and Hopkins, D. T. editors]. Westport, Connecticut: AVI.Google Scholar
Rand, W. M., Scrimshaw, N. S. & Young, V. R. (1985). Retrospective analysis of data from five long-term, metabolic balance studies: implications for understanding dietary nitrogen and energy utilization. American Journal of Clinical Nutrition 42, 1339–1350.CrossRefGoogle ScholarPubMed
Reddy, V. (1971). Lysine supplementation of wheat and nitrogen retention in children. American Journal of Clinical Nutrition 24, 1246–1249.CrossRefGoogle ScholarPubMed
Rennie, M. J., Edwards, R. H. T., Krywawych, S., Davies, C. T. M., Halliday, D., Waterlow, J. C. & Millward, D. J. (1981). Effect of exercise on protein turnover in man. Clinical Science 61, 627–639.CrossRefGoogle ScholarPubMed
Rennie, M. J., Hundal, H., Babij, P., MacLennon, P., Taylor, P. M., Watt, P. W., Jepson, M. M. & Millward, D. J. (1986). Characteristics of a glutamine carrier in skeletal muscle have important consequences for nitrogen loss in injury, infection and chronic disease. Lancet 50, 1008–1012.CrossRefGoogle Scholar
Rose, W. C. (1957). The amino acid requirements of adult man. Nutrition Abstracts and Reviews 27, 631–647.Google ScholarPubMed
Scrimshaw, N. S. (1981). Nutritional significance of protein quality: a global view. In Protein Quality in Humans: Assessment and in vitro Estimation. pp. 3–18. [Bodwell, C. E., Atkins, J. S. and Hopkins, D. T. editors]. Westport, Connecticut: AVI.Google Scholar
Scrimshaw, N. S., Taylor, Y. S. M. & Young, V. R. (1973). Lysine supplementation of wheat gluten at adequate and restricted energy intakes in young men. American Journal of Clinical Nutrition 39, 16–24.Google Scholar
Scrimshaw, N. S., Wayler, A. H., Murray, E., Steinke, F. H., Rand, W. M. & Young, V. R. (1983). Nitrogen balance response in young men given one of two isolated soy proteins or milk proteins. Journal of Nutrition 113, 2492–2497.CrossRefGoogle ScholarPubMed
Snyderman, S. E., Holt, L. E. Jr, Dancis, J., Roitman, E., Boyer, A. & Balis, M. E. (1962). ‘Unessential’ nitrogen: a limiting factor for human growth. Journal of Nutrition 78, 57–114.CrossRefGoogle ScholarPubMed
Souba, W., Smith, R. J. & Wilmore, D. W. (1985). Glutamine metabolism by the intestinal tract. Journal of Parenteral & Enteral Nutrition 9, 608–616.CrossRefGoogle ScholarPubMed
Sukhatme, P. V. & Margen, S. (1978). Models for protein deficiency. American Journal of Clinical Nutrition 31, 1237–1248.CrossRefGoogle ScholarPubMed
Swendseid, M. E., Hickson, J. B. & Friedrich, B. W. (1962). Effect of nonessential nitrogen supplements on growth and on the amino acid content in plasma and muscle of weanling rats fed a low-protein diet. Journal of Nutrition 78, 115–119.CrossRefGoogle Scholar
Tanaka, N., Kubo, K., Shiraki, K., Koishi, H. & Yoshimura, H. (1980). A pilot study of the protein metabolism in the Papua New Guinea Highlanders. Journal of Nutritional Science and Vitaminology 26, 247–259.CrossRefGoogle ScholarPubMed
Uauy, R., Yanez, E., Ballester, D., Barrera, G., Guzman, E., Saitua, M. T. & Zacarias, I. (1982). Obligatory urinary and faecal nitrogen losses in young Chilean men given two levels of energy intake. British Journal of Nutrition 47, 11–20.CrossRefGoogle ScholarPubMed
Vest, M. F. & Rossier, R. (1963). Detoxification in the newborn; the ability of the newborn infant to form conjugates with glucuronic acid, glycine, acetate and glutathione. Annals of the New York Academy of Science III, 183–198.CrossRefGoogle Scholar
Vinnars, E., Bergstrom, J. & Furst, P. (1975). Influence of postoperative state on the intracellular free acids in human muscle tissue. Annals of Surgery 163, 665–670.CrossRefGoogle Scholar
Waterlow, J. C. (1980). Protein turnover in the whole animal. Investigative and Cell Pathology 3, 107–119.Google ScholarPubMed
Weller, L. A., Calloway, D. H. & Margen, S. (1971). Nitrogen balance of men fed amino acid mixtures based on Rose's requirements, egg white protein, and serum free amino acid patterns. Journal of Nutrition 101, 1499–1508.CrossRefGoogle ScholarPubMed
Widdowson, E. W., Southgate, D. A. T. & Hey, E. N. (1979). Body composition of the fetus and infant. In Nutrition and Metabolism of the Fetus and Infant, pp. 169–177 [Visser, H. K. A. editor]. The Hague: Martinus Nijhoff.CrossRefGoogle Scholar
Yanez, E., Uauy, R., Ballester, D., Barrera, G., Chavez, N., Guzman, E., Saitua, M. T. & Zacarias, I. (1982). Capacity of the Chilean mixed diet to meet the protein and energy requirements of young male adults. British Journal of Nutrition 47, 1–10.CrossRefGoogle Scholar
Young, V. R., Fajardo, L., Murray, E., Rand, W. M. & Scrimshaw, N. S. (1975). Protein requirements of man: comparative nitrogen balance response within the submaintenance-to-maintenance range of intakes of wheat and beef proteins. Journal of Nutrition 105, 534.CrossRefGoogle ScholarPubMed
Young, V. R. & Pellet, P. L. (1989). How to evalute dietary protein. In Milk Proteins in Human Nutrition, pp. 7–36 [Barth, C. A. and Schlimme, E. editors]. Darmstadt: Steinkopff.CrossRefGoogle Scholar
Young, V. R., Puig, M., Queiroz, E., Scrimshaw, N. S. & Rand, W. M. (1984). Evaluation of the protein quality of an isolated soy protein in young men: relative nitrogen requirements and effect of methionine supplementation. American Journal of Clinical Nutrition 39, 16–24.CrossRefGoogle ScholarPubMed
Young, V. R., Taylor, Y. S. M., Rand, W. R. & Scrimshaw, N. S. (1973). Protein requirements of man: efficiency of egg protein utilization at maintenance and sub-maintenance levels in young men. Journal of Nutrition 103, 1164–1174.CrossRefGoogle Scholar
Yu, Y. M., Yang, R. D., Matthews, D. E., Wen, Z. M., Burke, J. F., Bier, D. M. & Young, V. R. (1985). Quantitative aspects of glycine and alanine nitrogen metabolism in postabsorptive young men: effects of level of nitrogen and dispensable amino acid intake. Journal of Nutrition 115, 399–410.CrossRefGoogle ScholarPubMed