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Alcohol drinking and cardiac risk

Published online by Cambridge University Press:  14 December 2007

Benjamin Buemann ,
Jørn Dyerberg  and
Arne Astrup
Benjamin Buemann*
Affiliation:
Research Department of Human Nutrition and Center for Advanced Food Studies, The Royal Veterinary and Agricultural University, Rolighedsvej 30, 1958 Frederiksberg, Denmark
Jørn Dyerberg
Affiliation:
Research Department of Human Nutrition and Center for Advanced Food Studies, The Royal Veterinary and Agricultural University, Rolighedsvej 30, 1958 Frederiksberg, Denmark
Arne Astrup
Affiliation:
Research Department of Human Nutrition and Center for Advanced Food Studies, The Royal Veterinary and Agricultural University, Rolighedsvej 30, 1958 Frederiksberg, Denmark
*
*Corresponding author: Benjamin Buemann, fax +45 35 28 24 83, email [email protected]
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Abstract

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The present paper provides a comprehensive review of the literature pertaining to the impact of alcohol intake on cardiovascular disease. Both cross-sectional and prospective studies have disclosed a negative association between moderate intake of alcoholic beverages and cardiovascular disease. The relationship appears to be present for both wine, beer and spirits. Effects of alcohol itself and also the role of different cardio-protective substances in alcoholic beverages are discussed. Alcohol has been suggested to beneficially affect the blood lipid profile, as it increases plasma HDL-cholesterol level. Furthermore, it may inhibit thrombogenesis by reducing thromboxan formation and decreasing the plasma level of fibrinogen. However, high blood concentrations of alcohol may impair fibrinolysis by increasing plasma plasminogen activator inhibitor-1 level. This action could contribute to explaining the ‘U’-shaped association between alcohol intake and cardiac events. Alcohol seems to promote abdominal fat distribution, but the importance of this effect in non-obese individuals is uncertain. Wine in particular, but also beer, contains polyphenols which act as antioxidants. Their action could maintain the integrity of the endothelial function by reducing the formation of superoxide. Moreover, these antioxidants may protect against LDL oxidation and modulate the macrophage attack on the endothelium. Although the cardio-protective effect of alcohol can hardly be addressed in healthy individuals by intervention studies with hard end points, there are many observational and experimental findings indicating that moderate alcohol drinking possesses properties preventive of cardiovascular disease.

Keywords

AlcoholAntioxidantsBlood lipidsCardiovascular diseaseHaemostasisAlcoholic beverage
Type
Research Article
Information
Nutrition Research Reviews , Volume 15 , Issue 1 , June 2002 , pp. 91 - 121
Copyright
Copyright © CABI Publishing 2002

References

Abbasi, F, McLaughlin, T, Lamendola, C, Lipinska, I, Tofler, G & Raeven, GM (1999) Comparison of plasminogen activator inhibitor-1 concentration in insulin-resistant versus insulin-sensitive healthy women. Arteriosclerosis, Thrombosis and Vascular Biology 19, 2818–2821.CrossRefGoogle ScholarPubMed
Abe, H, Kawano, Y, Kojima, S, Ashida, T, Kuramochi, M, Matsuoka, H & Omae, T (1994) Biphasic effects of repeated alcohol intake on 24-hour blood pressure in hypertensive patients. Circulation 89, 2626–2633.CrossRefGoogle ScholarPubMed
Abramson, JL, Williams, SA, Krumholz, HM & Vaccarino, V (2001) Moderate alcohol consumption and risk of heart failure among older persons. Journal of the American Medical Association 285, 1971–1977.CrossRefGoogle ScholarPubMed
Aguilera, MT, de la Sierra, A, Coca, A, Estruch, R, Fernández-Solá, J & Urbano-Márquez, A (1999) Effect of alcohol abstinence on blood pressure. Assessment by 24-hour ambulatory blood pressure monitoring. Hypertension 33, 653–657.CrossRefGoogle ScholarPubMed
Ajani, UA, Hennekens, CH, Spelsberg, A & Manson, JE (2000) Alcohol consumption and risk of type 2 diabetes mellitus among US male physicians. Archives of Internal Medicine 160, 1025–1030.CrossRefGoogle ScholarPubMed
Albert, CM, Manson, JE, Cook, NR, Ajani, UA, Gaziano, M & Hennekens, CH (1999) Moderate alcohol consumption and the risk of sudden cardiac death among US male physicians. Circulation 100, 944–950.CrossRefGoogle ScholarPubMed
Algra, A, Tijssen, JG, Roelandt, JR, Pool, J & Lubsen, J (1993) Heart rate variability from 24-hour electrocardiography and the 2-years risk for sudden death. Circulation 88, 180–185.CrossRefGoogle Scholar
Anonymous, (1987) Moderate alcohol consumption increases plasma high-density lipoprotein cholesterol. Nutrition Reviews 45, 8–10.Google Scholar
Arkwright, PD, Beilen, LJ, Rouse, I, Armstrong, BK & Vandongen, R (1982) Effects of alcohol use and other aspects of lifestyle on blood pressure levels and prevalence of hypertension in a working population. Circulation 66, 60–66.CrossRefGoogle Scholar
Armellini, F, Zamboni, M, Frigo, L, Mandragona, R, Robbi, R, Micciolo, R & Bosello, O (1993) Alcohol consumption, smoking habits and body fat distribution in Italian men and women aged 20–60 years. European Journal of Clinical Nutrition 47, 52–60.Google ScholarPubMed
Avogaro, A, Fontana, P, Valerio, A, Trevisan, R, Riccio, A, Del Prato, S, Nosadini, R, Tiengo, A & Crepaldi, G (1987) Alcohol impairs insulin sensitivity in normal subjects. Diabetes Research 5, 23–27.Google ScholarPubMed
Baraona, E & Lieber, CS (1979) Effects of ethanol on lipid metabolism. Journal of Lipid Research 20, 289–315.CrossRefGoogle ScholarPubMed
Bell, RA, Mayer-Davis, E, Martin, MA, D'Agostino, RB & Haffner, SM (2000) Associations between alcohol consumption and insulin sensitivity and cardiovascular disease risk factors. Diabetes Care 23, 1630–1636.CrossRefGoogle ScholarPubMed
Berliner, JA, Navab, M, Fogelman, AM, Frank, JS, Demer, LL, Edwards, PA, Watson, AD & Lusis, AJ (1995) Atherosclerosis: Basic mechanisms. Oxidation, inflammation, and genetics. Circulation 91, 2488–2496.CrossRefGoogle ScholarPubMed
Bierenbaum, ML, Struck, ML, Tomeo, AC, Halley, J & Watkins, TR (1994) Effect of red and white wine on serum|lipids, platelet aggregation, oxidation products and antioxidants. Clinical Research. 157A Abstr.Google Scholar
Bobak, M, Skodova, Z & Marmot, M (2000) Effect of beer drinking on risk of myocardial infarction: population based case–control study. British Medical Journal 320, 1378–1379.CrossRefGoogle ScholarPubMed
Bourne, L, Paganga, G, Baxter, D, Hughes, P & Rice-Evans, C (2000) Absorption of ferulic acid from low-alcohol beer. Free Radical Research 32, 273–280.CrossRefGoogle ScholarPubMed
Brattstöm, L & Wilcken, DEL (2000) Homocysteine and cardiovascular disease: cause or effect?. American Journal of Clinical Nutrition 72, 315–323.CrossRefGoogle Scholar
Brenn, T (1986) The Tromsø heart study: alcoholic beverage and coronary risk factors. Journal of Epidemiology and Community Health 40, 249–256.CrossRefGoogle ScholarPubMed
Burr, ML, Fehily, AM, Butland, BK, Bolton, CH & Eastham, RD (1986) Alcohol and high-density-lipoprotein cholesterol: a randomized controlled trial. British Journal of Nutrition 56, 81–86.CrossRefGoogle ScholarPubMed
Cao, G, Russell, RM, Lischner, N & Prior, RL (1998) Serum antioxidant capacity is increased by consumption of strawberries, spinach, red wine or vitamin C in elderly women. Journal of Nutrition 128, 2383–2390.CrossRefGoogle ScholarPubMed
Casassus, P, Fontbonne, A, Thibult, N, Ducimetière, P, Richard, JL, Claude, J-R, Warnet, J-M, Rosselin, G & Eschwège, E (1992) Upper body fat distribution: A hyperinsulinemia-independent predictor of coronary heart disease mortality. The Paris prospective study. Arteriosclerosis and Thrombosis 12, 1387–1392.CrossRefGoogle ScholarPubMed
Chan, MM-Y, Mattiacci, JA, Hwang, HS, Shah, A & Fong, D (2000) Synergy between ethanol and grape polyphenols, quercetin, and|resveratrol, in the inhibition of the inducible nitric oxide synthase pathway. Biochemical Pharmacology 60, 1539–1548.CrossRefGoogle ScholarPubMed
Chen, F, Lu, Y, Demers, LM, Rojanasakul, Y, Shi, X, Vallyathan, V & Castranova, V (1998) Role of hydroxyl radical in silica-induced NF-κB activation in macrophages. Annals of Clinical and Laboratory Science 28, 1–13.Google ScholarPubMed
Cigolini, M, Seidell, JC, Targher, G, Deslypere, JP, Éllsinger, BM, Charzewska, J, Cruz, A & Björntorp, P (1995) Fasting serum insulin in relation to components of the metabolic syndrome in European healthy men: The European Fat Distribution Study. Metabolism 44, 35–40.CrossRefGoogle ScholarPubMed
Cigolini, M, Targher, G, Andreis, IAB, Tonoli, M, Filippi, F, Muggeo, M & De Sandre, G (1996) Moderate alcohol consumption and its relation to visceral fat and plasma androgens in healthy women. International Journal of Obesity and Related Disorders 20, 206–212.Google ScholarPubMed
Cleophas, TJ (1999) Wine, beer and spirits and the risk of myocardial infarction: a systematic review. Biomedicine and Pharmacotherapy 53, 417–423.CrossRefGoogle ScholarPubMed
Cleophas, TJ, Hornstra, N, van Hoogstraten, B & van der Meulen, J (2000) Homocysteine, a risk factor for coronary artery disease or not? A meta-analysis. American Journal of Cardiology 86, 1005–1009.CrossRefGoogle ScholarPubMed
Cook, NR, Cohen, J, Herbert, PR, Taylor, JO & Hennekens, CH (1995) Implications of small reductions in diastolic blood pressure for primary prevention. Archives of Internal Medicine 155, 701–709.CrossRefGoogle ScholarPubMed
Cooke, KM, Frost, G & Stokes, GS (1983) Blood pressure and its relationship to low levels of alcohol consumption. Clinical and Experimental Pharmacology and Physiology 10, 229–233.CrossRefGoogle ScholarPubMed
Cordain, L, Bryan, ED, Melby, CL & Smith, MJ (1997) Influence of moderate daily wine consumption on body weight regulation and metabolism in healthy free-living males. Journal of the American College of Nutrition 16, 134–139.CrossRefGoogle ScholarPubMed
Cordain, L, Melby, CL, Hamamoto, AE, O Neill, DS, Cornier, MA, Barakat, HA, Israel, RG & Hill, JO (2000) Influence of moderate chronic wine consumption on insulin sensitivity and other correlates of syndrome X in moderately obese women. Metabolism 49, 1473–1478.CrossRefGoogle ScholarPubMed
Couzigou, P, Fleury, B, Crockett, R, Rautou, JJ, Blanchard, P, Lemoine, F, Richard-Molard, B & Béraud, C (1984) High density lipoprotein cholesterol and apoprotein A1 in healthy volunteers during long-term moderate alcohol intake. Annals of Nutrition and Metabolism 28, 377–384.CrossRefGoogle ScholarPubMed
Crouse, JR & Grundy, SM (1984) Effects of alcohol on plasma lipoproteins and cholesterol and triglyceride metabolism in man. Journal of Lipid Research 25, 486–496.CrossRefGoogle ScholarPubMed
Cuevas, AM, Guasch, V, Castillo, O, Irribarra, V, Mizon, C, San Martin, A, Strobel, P, Perez, D, Germain, AM & Leighton, F (2000) A high-fat diet induces and red wine counteracts endothelial dysfunction in human volunteers. Lipids 35, 143–148.CrossRefGoogle ScholarPubMed
Demrow, HS, Slane, PR & Folts, JD (1995) Administration of wine and grape juice inhibits in vivo platelet activity and thrombosis in stenosed canine coronary arteries. Circulation 91, 1182–1188.CrossRefGoogle ScholarPubMed
Diaz, MN, Frei, B, Vita, JA & Keaney, JF (1997) Antioxidants and atherosclerotic heart disease. New England Journal of Medicine 337, 408–416.CrossRefGoogle ScholarPubMed
Dimmitt, SB, Rakic, V, Puddey, IB, Baker, R, Oostryck, R, Adams, MJ, Chesterman, CN, Burke, V & Beilin, LJ (1998) The effect of alcohol on coagulation and fibrinolytic factors: a controlled trial. Blood Coagulation and Fibrinolysis 9, 39–45.CrossRefGoogle ScholarPubMed
Fenn, CG & Littleton, JM (1982) Inhibition of platelet aggregation by ethanol in vitro shows specificity for aggregating agent used and is influenced by platelet lipid composition. Thrombosis and Haemostasis 48, 49–53.Google ScholarPubMed
Fitzpatrick, DF, Hirschfield, SL & Coffey, RG (1993) Endothelium-dependent vasorelaxing activity of wine and other grape products. American Journal of Physiology 265, H774–H778.Google ScholarPubMed
Flanagan, DEH, Moore, VM, Godsland, IF, Cockington, RA, Robinson, JS & Phillips, DI (2000) Alcohol consumption and insulin resistance in young adults. European Journal of Clinical Investigation 30, 297–301.CrossRefGoogle ScholarPubMed
Flesch, M, Schwarz, A & Böhm, M (1998) Effects of red and white wine on endothelial-dependent vasorelaxation of rat aorta and human coronary arteries. American Journal of Physiology 275, H1183–H1190.Google Scholar
Frankel, EN, Kanner, J, German, JB, Parks, E & Kinsella, JE (1993) Inhibition of oxidation of human low-density lipoprotein by phenolic substances in red wine. Lancet 341, 454–457.CrossRefGoogle ScholarPubMed
Fuhrman, B, Lavy, A & Aviram, M (1995) Consumption of red wine with meals reduces the susceptibility of human plasma and low-density lipoprotein to lipid peroxidation. American Journal of Clinical Nutrition 61, 549–554.CrossRefGoogle ScholarPubMed
Fumeron, F, Betoulle, D, Luc, G, Behague, I, Ricard, S, Poirier, O, Jemaa, R, Evans, A, Arveiler, D, Marques-Vidal, P, Bard, J-M, Fruchart, J-C, Ducimetière, P, Apfelbaum, M & Cambien, F (1995) Alcohol intake modulates the effect of polymorphism of the cholesteryl ester transfer protein gene on plasma high density lipoprotein and risk of myocardial infarction. Journal of Clinical Investigation 96, 1664–1671.CrossRefGoogle ScholarPubMed
Gasbarrini, A, Addolorato, G, Simoncini, M, Gasbarrini, G, Fantozzi, P, Mancini, F, Montanari, L, Nardini, M, Ghiselli, A & Scaccini, C (1998) Beer affects oxidative stress due to ethanol in rats. Digestive Diseases and Science 43, 1332–1338.CrossRefGoogle ScholarPubMed
Gaziano, JM, Buring, JE, Breslow, JL, Goldhaber, SZ, Rosner, B, VanDenburgh, M, Willet, W & Hennekens, CH (1993) Moderate alcohol intake, increased levels of high-density lipoprotein and its subfractions, and decreased risk of myocardial infarction. New England Journal of Medicine 329, 1829–1834.CrossRefGoogle ScholarPubMed
Gaziano, JM, Hennekens, CH, Godfried, SL, Sesso, HD, Glynn, RJ, Breslow, JL & Buring, JE (1999) Type of alcoholic beverage and risk of myocardial infarction. American Journal of Cardiology 83, 52–57.CrossRefGoogle ScholarPubMed
Ghiselli, A, Nardini, M, Baldi, A & Scaccini, C (1998) Antioxidant activity of different phenolic fractions separated from an Italian red wine. Journal of Agricultural and Food Chemistry 46, 361–367.CrossRefGoogle ScholarPubMed
Ghiselli, A, Natella, F, Guidi, A, Montanri, L, Fantozzi, P & Scaccini, C (2000) Beer increases plasma antioxidant capacity in humans. Journal of Nutritional Biochemistry 11, 76–80.CrossRefGoogle ScholarPubMed
Gillman, MW, Cook, NR, Evans, DA, Rosner, B & Hennekens, CH (1995) Relationship of alcohol intake with blood pressure in young adults. Hypertension 25, 1106–1110.CrossRefGoogle ScholarPubMed
Gordon, T, Ernst, N, Fisher, M & Rifkind, BM (1981) Alcohol and high-density lipoprotein cholesterol. Circulation 64,Suppl. III, 63–67.Google ScholarPubMed
Gorinstein, S, Zemser, M, Berliner, M, Goldstein, R, Libman, I, Trakhtenberg, S & Caspi, A (1997 a) Moderate beer consumption and positive biochemical changes in patients with coronary atherosclerosis. Journal of Internal Medicine 242, 219–224.CrossRefGoogle ScholarPubMed
Gorinstein, S, Zemser, M, Lichman, I, Berebi, A, Kleipfish, A, Libman, I, Trakhtenberg, S & Caspi, A (1997 b) Moderate beer consumption and the blood coagulation in patients with coronary artery disease. Journal of Internal Medicine 241, 47–51.CrossRefGoogle ScholarPubMed
Greenspon, AJ & Schaal, SF (1983) The holiday heart: electrophysiologic studies of alcohol effects in alcoholics. Annals of Internal Medicine 98, 135–139.CrossRefGoogle ScholarPubMed
Grønbæk, M, Deis, A, Sørensen, TIA, Becker, U, Borch-Johansen, K, Müller, C, Schnohr, P & Jensen, G (1994) Influence of sex, age, body mass index, and smoking on alcohol intake and mortality. British Medical Journal 308, 302–306.CrossRefGoogle ScholarPubMed
Grønbæk, M, Deis, A, Sørensen, TIA, Becker, U, Schnohr, P & Jensen, G (1995) Mortality associated with moderate intakes of wine, beer, or spirits. British Medical Journal 310, 1165–1169.CrossRefGoogle ScholarPubMed
Grundy, SM (2001) Non-high-density lipoprotein cholesterol level as potential risk predictor and therapy target. Archives of Internal Medicine 161, 1379–1380.CrossRefGoogle ScholarPubMed
Gryglewski, RJ, Palmer, RM & Moncada, S (1986) Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor. Nature 320, 454–456.CrossRefGoogle ScholarPubMed
Hagiage, M, Marti, C, Rigaud, D, Senault, C, Fumeron, F, Apfelbaum, M & Girard-Globa, A (1992) Effect of moderate alcohol intake on the lipoproteins of normotriglyceridemic obese subject compared with normoponderal controls. Metabolism 41, 856–861.CrossRefGoogle ScholarPubMed
Hagstrup Christensen, J, Skou, AS, Fog, L, Ellegaard Hansen, V, Vesterlund, T, Dyerberg, J, Toft, E & Berg Schmidt, E (2001) Marine n-3 fatty|acids, wine intake, and heart rate variability in patients referred for coronary angiography. Circulation 103, 651–657.CrossRefGoogle Scholar
Handa, K, Kono, S, Ishii, H, Shinchi, K, Imanishi, K & Arakawa, K (1994) Relationship of alcohol consumption and smoking to plasma cortisol and blood pressure. Journal of Human Hypertension 8, 891–894.Google ScholarPubMed
Hartung, GH, Foreyt, JP, Mitchell, RE, Mitchell, JG, Reeves, RS & Gotto, AM (1983) Effects of alcohol intake on high-density lipoprotein cholesterol levels in runners and inactive men. Journal of the American Medical Association 249, 747–750.CrossRefGoogle ScholarPubMed
Hartung, GH, Foreyt, JP, Reeves, RS, Krock, LP, Patsch, W, Patsch, JR & Gotto, AM (1990) Effect of alcohol dose on plasma lipoprotein subfractions and lipolytic enzyme activity in active and inactive men. Metabolism 39, 81–86.CrossRefGoogle ScholarPubMed
Haskell, WL, Camargo, C, Williams, PT, Vranizan, KM, Krauss, RM, Lindgren, FT & Wood, PD (1984) The effect of cessation and resumption of moderate alcohol intake on serum high-density-lipoprotein subfractions. New England Journal of Medicine 310, 805–810.CrossRefGoogle ScholarPubMed
Heery, JM, Kozak, M, Stafforini, DM, Jones, DA, Zimmerman, GA & McIntyre, TM (1995) Oxidatively modified LDL contains phospholipids with platelet-activating factor-like activity and stimulates the growth of smooth muscle cells. Journal of Clinical Investigation 96, 2322–2330.CrossRefGoogle ScholarPubMed
Hein, HO, Suadicani, P & Gyntelberg, F (1996) Alcohol consumption, serum low density lipoprotein cholesterol concentration, and risk of ischaemic heart disease: six year follow up in the Copenhagen male study. British Medical Journal 312, 736–741.CrossRefGoogle ScholarPubMed
Hendriks, HF, Veenstra, J, Van Tol, A, Groener, JEM & Schaafsma, G (1998) Moderate doses of alcoholic beverages with dinner and postprandial high density lipoprotein composition. Alcohol and Alcoholism 33, 403–410.CrossRefGoogle ScholarPubMed
Hendriks, HFJ, Veenstra, J, Wierik, EJMV, Schaafsma, G & Kluft, C (1994) Effect of moderate dose of alcohol with evening meal on fibrinolytic factors. British Medical Journal 308, 1003–1006.CrossRefGoogle ScholarPubMed
Hertog, MGL, Feskens, EJM, Hollman, PCH, Katan, MB & Kromhout, D (1993) Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study. Lancet 342, 1007–1011.CrossRefGoogle ScholarPubMed
Hertog, MGL, Kromhout, D, Aravanis, C, Blackburn, H, Buzina, R, Fidanza, F, Giampaoli, S, Jansen, A, Menotti, A, Nedeljkovic, S, Pekkarinen, M, Simic, BS, Toshima, H, Feskens, EJM, Hollman, PCH & Katan, MB (1995) Flavonoid intake and long-term risk of coronary heart disease and cancer in the seven countries study. Archives of Internal Medicine 155, 381–386.CrossRefGoogle ScholarPubMed
Hillbom, M, Muuronen, A, Lowbeer, C, Anggard, E, Bevibng, H & Kangasaho, M (1985) Platelet thromboxane formation and bleeding time is influenced by ethanol withdrawal but not by cigarette smoking. Thrombosis and Haemostasis 53, 419–422.Google Scholar
Hines, LM, Stampfer, MJ, Ma, J, Gaziano, M, Ridker, PM, Hankinson, SE, Sacks, F, Rimm, EB & Hunter, DJ (2001) Genetic variation in alcohol dehydrogenase and the beneficial effect of moderate alcohol consumption on myocardial infarction. New England Journal of Medicine 344, 549–555.CrossRefGoogle ScholarPubMed
Hohnloser, SH, Klingenheben, T, Zabel, M & Li, YG (1997) Heart rate variability used as an arrhythmia risk stratifier after myocardial infarction. Pacing and Clinical Electrophysiology 20, 2594–2601.CrossRefGoogle ScholarPubMed
Hokanson, JE, Brunzell, JD, Jarvik, GP, Wijsman, EM & Austin, MA (1999) Linkage of low-density lipoprotein size to the lipoprotein lipase gene in heterozygous lipoprotein lipase deficiency. American Journal of Human Genetics 64, 608–618.CrossRefGoogle Scholar
Hooper, L, Ness, AR & Smith, GD (2001) Meta-analysis of effect of high vs low vitamin E intake on cardiovascular mortality for observational and intervention studies. Lancet 357. 1705.CrossRefGoogle Scholar
Howes, LG, Krum, H & Phillips, PA (1990) Effects of regular alcohol consumption on 24 hour ambulatory blood pressure recordings. Clinical and Experimental Pharmacology and Physiology 17, 247–250.CrossRefGoogle ScholarPubMed
Hulley, SB & Gordon, S (1981) Alcohol and high-density lipoprotein cholesterol. Causal inference from diverse study designs. Circulation 64, Suppl. III, 57–63.Google ScholarPubMed
Ida, Y, Tsujimaru, S, Nakamaura, K, Shirao, I, Mukasa, H, Egami, H & Nakazawa, Y (1992) Effects of acute and repeated alcohol ingestion on hypothalamic-pituitary-gonadal and hypothalamic-pituitary-adrenal functioning in normal males. Drug and Alcohol Dependence 31, 57–64.CrossRefGoogle ScholarPubMed
Kahn, HS & Williamson, DF (1994) Abdominal obesity and mortality risk among men in nineteenth-century North America. International Journal of Obesity 18, 686–691.Google ScholarPubMed
Kakko, S, Tamminen, M, Pälvänsalo, M, Kauma, H, Rantala, AO, Lilja, M, Reunanen, A, Kemäniemi, YA & Savolainen, MJ (2000) Cholesteryl ester transfer protein gene polymorphisms are associated with carotid atherosclerosis in men. European Journal of Clinical Investigation 30, 18–25.CrossRefGoogle ScholarPubMed
Kauhanen, J, Kaplan, GA, Goldberg, DE, Salonen, R & Salonen, JT (1999) Pattern of alcohol drinking and progression of atherosclerosis. Arteriosclerosis, Thrombosis and Vascular Biology 19, 3001–3006.CrossRefGoogle ScholarPubMed
Khaw, K-T, Wareham, N, Luben, R, Bingham, S, Oakes, S & Welch, A (2001) Glycated|haemoglobin, diabetes, and mortality in men in Norfolk cohort of European Prospective Investigation of Cancer and Nutrition (EPIC-Norfolk). British Medical Journal 322, 1–6.CrossRefGoogle ScholarPubMed
Kiechl, S, Willeit, J, Poewe, W, Egger, G, Oberhollenzer, F, Muggeo, M & Bonora, E (1996) Insulin sensitivity and regular alcohol consumption: large, prospective, cross sectional population study (Bruneck study). British Medical Journal 313, 1040–1044.CrossRefGoogle ScholarPubMed
Kiechl, S, Willeit, J, Rungger, G, Egger, G, Oberhollenzer, F & Bonora, E (1998) Alcohol consumption and atherosclerosis: what is the relation. Prospective results from the Bruneck Study. Stroke 29, 900–907.CrossRefGoogle ScholarPubMed
Kim, KM, Chun, SB, Koo, MS, Choi, WJ, Kim, TW, Kwon, YG, Chung, HT, Billiar, TR & Kim, YM (2001) Differential regulation of NO availability from macrophages and endothelial cells by the garlic component S-allyl cysteine. Free Radical Biology and Medicine 30, 747–756.CrossRefGoogle ScholarPubMed
Klurfeld, DM & Kritchevsky, D (1981) Different effects of alcoholic beverages on experimental atherosclerosis in rabbits. Experimental and Molecular Pathology 34, 62–71.CrossRefGoogle Scholar
Koskinen, P, Virolainen, J & Kupari, M (1994) Acute alcohol intake decreases short-term heart rate variability in healthy subjects. Clinical Science 87, 225–230.CrossRefGoogle ScholarPubMed
Langer, RD, Criqui, MH & Reed, DM (1992) Lipoproteins and blood pressure as biological pathways for effect of moderate alcohol consumption on coronary heart disease. Circulation 85, 910–915.CrossRefGoogle ScholarPubMed
LaPorte, RE, Cresanta, JL & Kuller, LH (1980) The relationship of alcohol consumption to atherosclerotic heart disease. Preventive Medicine 9, 22–40.CrossRefGoogle ScholarPubMed
Laug, WE (1983) Ethyl alcohol enhances plasminogen activator secretion by endothelial cells. Journal of the American Medical Association 250, 772–776.CrossRefGoogle ScholarPubMed
Lazarus, R, Sparrow, D & Weiss, ST (1997) Alcohol intake and insulin levels. The Normative Ageing Study. American Journal of Epidemiology 145, 909–916.CrossRefGoogle Scholar
Lee, AJ, Flanagan, PA, Rumley, A, Fowkes, FGR & Lowe, GDO (1995) Relationship between alcohol intake and tissue plaminogen activator antigen and other haemostatichemostatic factors in the general population. Fibrinolysis 8, 49–54.CrossRefGoogle Scholar
Leo, R, Pratico, D, Iuliano, L, Pulcinelli, FM, Ghiselli, A, Pignatelli, P, Colavita, AR, FitzGerald, GA & Violi, F (1997) Platelet activation by superoxide anion and hydroxyl radicals intrinsically generated by platelets that had undergone anoxia and then reoxygenated. Circulation 95, 885–891.CrossRefGoogle ScholarPubMed
Lieber, CS (1991) Alcohol, liver, and nutrition. Journal of the American College of Nutrition 10, 602–632.CrossRefGoogle ScholarPubMed
McConnell, MV, Vavouranakis, I, Wu, LL, Vaughan, DE & Ridker, PM (1997) Effects of a single, daily alcoholic beverage on lipid and hemostatic markers of cardiovascular risk. American Journal of Cardiology 80, 1226–1228.CrossRefGoogle ScholarPubMed
McElduff, PM & Dobson, AJ (1997) How much alcohol and how often? Population based case–control study of alcohol consumption and risk of a major coronary event. British Medical Journal 314, 1159–1164.CrossRefGoogle ScholarPubMed
Maiorano, G, Bartolomucci, F, Contursi, V, Saracino, E & Agostinacchio, E (1995) Effect of alcohol consumption versus abstinence on 24-h blood pressure profile in normotensive alcoholic patients. Journal of Hypertension 8, 80–81.CrossRefGoogle ScholarPubMed
Mantle, D & Preedy, VR (1999) Free radicals as mediators of alcohol toxicity. Adverse Drug Reactions and Toxicological Reviews 18, 235–252.Google ScholarPubMed
Maresca, G, Di Blasio, A, Marchioli, R & Di Minno, G (1999) Measuring plasma fibrinogen to predict stroke and myocardial infarction. An update. Arteriosclerosis, Thrombosis, and Vascular Biology 19, 1368–1377.CrossRefGoogle ScholarPubMed
Marmot, MG (1984) Alcohol and coronary heart disease. International Journal of Epidemiology 13, 160–167.CrossRefGoogle ScholarPubMed
Mayer, O, Simon, J & Rosolová, H (2001) A population study of the influence of beer consumption on folate and homocysteine concentrations. European Journal of Clinical Nutrition 55, 605–609.CrossRefGoogle ScholarPubMed
Meade, TW, Vickers, MV, Thompson, SG, Stirling, Y, Haines, AP & Miller, GJ (1985) Epidemiological characteristics of platelet aggregability. British Medical Journal 290, 428–432.CrossRefGoogle ScholarPubMed
Mennen, LI, Balkau, B, Vol, S, Cacès, E & Eschwège, E (1999) Fibrinogen. A possible link between alcohol consumption and cardiovascular disease. Arteriosclerosis, Thrombosis, and Vascular Biology 19, 887–892.CrossRefGoogle ScholarPubMed
Mezey, E (1985) Metabolic effects of alcohol. Federation Proceedings 44, 134–138.Google ScholarPubMed
Mikhailidis, DP, Barradas, MA, Epemolu, O & Dandona, P (1987) Ethanol ingestion inhibits human whole blood platelet impedance aggregation. American Journal of Clinical Pathology 88, 342–345.CrossRefGoogle ScholarPubMed
Miranda, CL, Stevens, JF, Ivanov, V, McCall, M, Frei, B, Deinzer, ML & Buhler, DR (2000) Antioxidant and prooxidant actions of prenylated and nonprenylated chalones and flavones in vitro. Journal of Agricultural and Food Chemistry 48, 3876–3884.CrossRefGoogle Scholar
Moro, MÁ, Darley-Usmar, VM, Goodwin, DA, Read, NG, Zamora-Pino, R, Feelisch, M, Radomski, MW & Moncade, S (1994) Paradoxical fate and biological actions of peroxynitrite on human platelets. Proceedings of the National Academy of Sciences of the USA 91, 6702–6706.CrossRefGoogle ScholarPubMed
Nakamura, T, Tokunaga, K, Shimomura, I, Nishida, M, Yoshida, S, Kotani, K, Islam, AH, Keno, Y, Kobatake, T & Nagai, Y (1994) Contribution of visceral fat accumulation to the development of coronary artery disease in non-obese men. Atherosclerosis 107, 239–246.CrossRefGoogle Scholar
Nanji, AA (1985) Alcohol and ischemic heart disease: wine, beer or both? International Journal of Cardiology 8, 487–489.CrossRefGoogle ScholarPubMed
Nappo, F, De Rosa, N, Marfella, R, De Lucia, D, Ingrosso, D, Perna, AF, Farzati, B & Giugliano, D (1999) Impairment of endothelial functions by acute hyperhomocysteinemia and reversal by antioxidant vitamins. Journal of the American Medical Association 281, 2113–2118.CrossRefGoogle ScholarPubMed
Nishiwaki, M, Ishikawa, T, Ito, T, Shige, H, Tomiyasu, K, Nakajima, K, Kondo, K, Hashimoto, H, Saitoh, K & Manabe, M (1994) Effects of alcohol on lipoprotein lipase, hepatic|lipase, cholesteryl ester transfer|protein, and lecithin:cholesterol acyltransferase in high-density lipoprotein cholesterol elevation. Atherosclerosis 111, 99–109.CrossRefGoogle ScholarPubMed
Numminen, H, Kobayashi, M, Uchiyama, S, Iwata, M, Ikeda, Y, Riutta, A, Syrjälä, M, Kekomaki, R & Hillbom, M (2000 a) Effects of alcohol and the evening meal on shear-induced platelet aggregation and urinary excretion of protanoids. Alcohol and Alcoholism 35, 594–600.CrossRefGoogle Scholar
Numminen, H, Syrjälä, M, Benthin, G, Kaste, M & Hillbom, M (2000 b) The effect of acute ingestion of a large dose of alcohol on the hemostatic system and its circadian variation. Stroke 31, 1269–1273.CrossRefGoogle ScholarPubMed
O'Callaghan, CJ, Phillips, PA, Krum, H & Howes, LG (1995) The effects of short-term alcohol intake on clinic and ambulatory blood pressure in normotensive social drinkers. American Journal of Hypertension 8, 572–577.CrossRefGoogle ScholarPubMed
Pace-Asciak, CR, Hahn, S, Diamandis, EP, Soleas, G & Goldberg, DM (1995) The red wine phenolics trans-resveratrol and quercetin block human platelet aggregation and eicosanoid synthesis: Implications for protection against coronary heart disease. Clinica Chimica Acta 235, 207–219.CrossRefGoogle ScholarPubMed
Pace-Asciak, CR, Rounova, O, Hahn, SE, Diamandis, EP & Goldberg, DM (1996) Wines and grape juices as modulators of platelet aggregation in healthy human subjects. Clinica Chimica Acta 246, 163–182.CrossRefGoogle ScholarPubMed
Parthasarathy, S, Steinberg, D & Witztum, JL (1992) The role of oxidized low-density lipoproteins in the pathogenesis of atherosclerosis. Annual Review of Medicine 43, 219–225.CrossRefGoogle ScholarPubMed
Paunio, M, Heinonen, O, Virtamo, J, Klag, MJ, Manninen, V, Albanes, D & Comstock, GW (1994) HDL cholesterol and mortality in Finnish Men with special reference to alcohol intake. Circulation 90, 2909–2918.CrossRefGoogle ScholarPubMed
Pellegrini, N, Pareti, FI, Stabile, F, Brusamolino, A & Simonetti, P (1996) Effects of moderate consumption of red wine on platelet aggregation and haemostatic variables in healthy volunteers. European Journal of Clinical Nutrition 50, 209–213.Google ScholarPubMed
Pendurthi, UR, Williams, JT & Rao, LVM (1999) Resveratrol, a polyphenolic compound found in wine, inhibits tissue factor expression in vascular cells. A possible mechanism for the cardiovascular benefits associated with moderate consumption of wine. Arteriosclerosis, Thrombosis and Vascular Biology 19, 419–426.CrossRefGoogle Scholar
Perry, IJ, Wannamethee, SG, Walker, MK, Thomson, AG, Whincup, PH & Shaper, AG (1995) Protective study of risk factors for development of non-insulin dependent diabetes in middle aged British men. British Medical Journal 310, 560–564.CrossRefGoogle Scholar
Pikaar, NA, Wedel, M, van der Beek, EJ, van Dokkum, Wim, Kempen, HJM, Kluft, C, Ockhuizen, T & Hermus, RJJ (1987) Effects of moderate alcohol consumption on platelet aggregation, fibrinolysis, and blood lipids. Metabolism 36, 538–543.CrossRefGoogle ScholarPubMed
Prentice, AM (1995) Alcohol and obesity. International Journal of Obesity and Related Disorders 19, Suppl. 5, S44–S50.Google ScholarPubMed
Prinz, PN, Roehrs, TA, Vitaliano, PP, Linnoila, M & Weitzman, ED (1980) Effect of alcohol on sleep and night time growth hormone and cortisol concentrations. Journal of Clinical Endocrinology and Metabolism 51, 759–764.CrossRefGoogle Scholar
Rakic, V, Puddey, IB, Burke, V, Dimmitt, SB & Beilin, LJ (1998) Influence of pattern of alcohol intake on blood pressure in regular drinkers: a controlled trial. Journal of Hypertension 16, 165–174.CrossRefGoogle ScholarPubMed
Rand, ML, Packham, MA, Kinlough-Rathbone, RL & Fraser, MJ (1988) Effects of ethanol on pathways of platelet aggregation in vitro. Thrombosis and Haemostasis 59, 383–387.Google ScholarPubMed
Rao, MN, Lin, QH, Marmillot, P, Seeff, LB, Strader, DB & Lakshman, MR (2000) High-density lipoproteins from human alcoholics exhibit impaired reverse cholesterol transport function. Metabolism 49, 1406–1410.CrossRefGoogle ScholarPubMed
Razay, G & Heaton, KW (1997) Moderate alcohol consumption has been shown previously to improve insulin sensitivity in men. British Medical Journal 314, 442–443.CrossRefGoogle ScholarPubMed
Razzaghi, H, Aston, CE, Hamman, RF & Kamboh, MI (2000) Genetic screening of the lipoprotein lipase gene for mutations associated with high triglyceride/low HDL-cholesterol levels. Human Genetics 107, 257–267.CrossRefGoogle ScholarPubMed
Renaud, S & De Lorgeril, M (1992) Wine, alcohol, platelets, and the French paradox for coronary heart disease. Lancet 339, 1523–1526.CrossRefGoogle ScholarPubMed
Renaud, SC, Beswick, AD, Fehily, AM, Sharp, DS & Elwood, PC (1992) Alcohol and platelet aggregation: the Caerphilly prospective heart disease study. American Journal of Clinical Nutrition 55, 1012–1017.CrossRefGoogle ScholarPubMed
Ridker, PM, Vaughan, DE, Stampfer, MJ, Glynn, RJ & Hennekens, CH (1994) Association of moderate alcohol consumption and plasma concentration of endogenous tissue-type plasminogen activator. Journal of the American Medical Association 272, 929–933.CrossRefGoogle ScholarPubMed
Rimm, EB, Giovannucci, EL, Willet, WC, Colditz, GA, Ascherio, A, Rosner, B & Stampfer, MJ (1991) Prospective study of alcohol consumption and risk of coronary disease in men. Lancet 338, 464–468.CrossRefGoogle ScholarPubMed
Rimm, EB, Klatsky, A, Grobbee, D & Stampfer, MJ (1996) Review of moderate alcohol consumption and reduced risk of coronary heart disease: is the effect due to beer, wine, or spirits?. British Medical Journal 312, 731–736.CrossRefGoogle ScholarPubMed
Rimm, EB, Willett, WC, Hu, FB, Sampson, L, Colditz, GA, Manson, JE, Hennekens, C & Stampfer, MJ (1998) Folate and vitamin B6 from diet and supplements in relation to risk of coronary heart disease among women. Journal of the American Medical Association 279, 359–364.CrossRefGoogle ScholarPubMed
Rimm, EB, Williams, P, Fosher, K, Criqui, M & Stampfer, MJ (1999) Moderate alcohol intake and lower risk of coronary heart disease: meta-analysis of effects on lipids and haemostatic factors. British Medical Journal 319, 1523–1528.CrossRefGoogle ScholarPubMed
Rubin, R (1989) Ethanol interferes with collagen-induced platelet activation by inhibition of arachidonic acid mobilization. Archives of Biochemistry and Biophysics 270, 99–113.CrossRefGoogle ScholarPubMed
Ruf, J-C, Berger, J-L & Renaud, S (1995) Platelet rebound effect of alcohol withdrawal and wine drinking in rats. Relation to tannins and lipid peroxidation. Arteriosclerosis, Thrombosis and Vascular Biology 15, 140–144.CrossRefGoogle ScholarPubMed
Rumpler, WV, Clevidence, BA, Muesing, RA & Rhodes, DG (1999) Change in women's plasma lipid and lipoprotein concentrations due to moderate consumption of alcohol are affected by dietary fat level. Journal of Nutrition 129, 1713–1717.CrossRefGoogle ScholarPubMed
Savolainen, MJ, Hannuksela, M, Seppänen, S, Kervinen, K & Kesäniemi, YA (1990) Increased high-density lipoprotein cholesterol concentration in alcoholics is related to low cholesteryl ester transfer protein activity. European Journal of Clinical Investigation 20, 593–599.CrossRefGoogle ScholarPubMed
Savolainen, MJ & Kesäniemi, YA (1995) Effects of alcohol on lipoproteins in relation to coronary heart disease. Current Opinion in Lipidology 6, 243–250.CrossRefGoogle ScholarPubMed
Schlotte, V, Sevanian, A, Hochstein, P & Weitmann, KU (1998) Effect of uric acid and chemical analogues on oxidation of human low density lipoprotein. Free Radicals in Biology and Medicine 25, 839–847.CrossRefGoogle ScholarPubMed
Serafini, M, Maiani, G & Ferro-Luzzi, A (1998) Alcohol-free red wine enhances plasma antioxidant capacity in humans. Journal of Nutrition 128, 1003–1007.CrossRefGoogle ScholarPubMed
Serebruany, VL, Lowry, DR, Fuzailov, SY, Levine, DJ, O'Connor, CM & Gurbel, PA (2000) Moderate alcohol consumption is associated with decreased platelet activity in patients presenting with acute myocardial infarction. Journal of Thrombosis and Thrombolysis 9, 229–234.CrossRefGoogle ScholarPubMed
Shah, JH (1988) Alcohol decreases insulin sensitivity in healthy subjects. Alcohol and Alcoholism 23, 103–109.Google ScholarPubMed
Shelmet, JJ, Reichard, GA, Skutches, CL, Hoeldtke, RD, Owen, OE & Boden, G (1988) Ethanol causes acute inhibition of carbohydrate, fat, and protein oxidation and insulin resistance. Journal of Clinical Investigation 81, 1137–1145.CrossRefGoogle ScholarPubMed
Sillanaukee, P, Koivula, T, Jokela, H, Myllyharju, H & Seppä, K (1993) Relationship of alcohol consumption to changes in HDL-subfractions. European Journal of Clinical Investigation 23, 486–491.CrossRefGoogle ScholarPubMed
Sillanaukee, P, Koivula, T, Jokela, H, Pitkäjärvi, T & Seppä, K (2000) Alcohol consumption and its relation to lipid-based cardiovascular risk factors among middle-aged women: the role of HDL3 cholesterol. Atherosclerosis 152, 503–510.CrossRefGoogle Scholar
Simon, J, Filipovsky, J, Rosolová, H, Topolcan, O & Karlicek, V (1988) Cross-sectional study of beer consumption and blood pressure in middle-aged men. Journal of Human Hypertension 2, 1–6.Google ScholarPubMed
Skutches, CL, Holroyde, CP, Myers, RN, Paul, P & Reichard, GA (1979) Plasma acetate turnover and oxidation. Journal of Clinical Investigation 64, 708–713.CrossRefGoogle ScholarPubMed
Slattery, ML, McDonald, A, Bild, DE, Caan, BJ, Hilner, JE, Jacobs, DR & Liu, K (1992) Associations of body fat and its distribution with dietary intake, physical|activity, alcohol, and smoking in blacks and whites. American Journal of Clinical Nutrition 55, 943–949.CrossRefGoogle ScholarPubMed
Stampfer, MJ, Sacks, FM, Simonettea, S, Willett, WC & Hennekens, CH (1991) A prospective study of cholesterol, apolipoproteins, and the risk of myocardial infarction. New England Journal of Medicine 325, 373–381.CrossRefGoogle ScholarPubMed
Stokes, PE (1973) Adrenocortical activation in alcoholics during chronic drinking. Annals of the New York Academy of Sciences 215, 77–83.CrossRefGoogle ScholarPubMed
Stubbs, CD & Rubin, R (1992) Effect of ethanol on platelet phopholipase A2. Lipids 27, 255–260.CrossRefGoogle Scholar
Suter, PM, Häsler, E & Vetter, W (1997) Effects of alcohol on energy metabolism and body weight regulation: Is alcohol a risk factor for obesity? Nutrition Reviews 55, 157–171.CrossRefGoogle ScholarPubMed
Taylor, KG, Carter, TJ, Valente, AJ, Wright, AD, Smith, JH & Matthews, KA (1981) Sex differences in the relationships between obesity, alcohol consumption and cigarette smoking and serum lipid and lipoprotein concentrations in a normal population. Atherosclerosis 38, 11–18.CrossRefGoogle Scholar
Thögersen, AM, Jansson, J-H, Boman, K, Nilsson, TK, Weinehall, L, Huhtasaari, F & Hallmans, G (1998) High plasminogen activator inhibitor and tissue plasminogen activator levels in plasma precede a first acute myocardial infarction in both men and women. Evidence for the fibrinolytic system as an independent primary risk factor. Circulation 98, 2241–2247.CrossRefGoogle ScholarPubMed
Thome, J, Foley, P, Gsell, W, Davids, E, Wodarz, N, Wiesbeck, A, Böning, J & Riederer, P (1997) Increased concentrations of manganese superoxide dismutase in serum of alcohol-dependent patients. Alcohol and Alcoholism 32, 65–69.CrossRefGoogle ScholarPubMed
Tjønneland, A, Grønbæk, M, Stripp, C & Overvad, K (1999) Wine intake and diet in a random sample of 48763 Danish men and women. American Journal of Clinical Nutrition 69, 49–54.CrossRefGoogle Scholar
Trevithick, CC, Vinson, JA, Caulfield, J, Rahman, F, Derksen, T, Bocksch, L, Hong, S, Srefan, A, Teufel, K, Wu, N, Hirst, M & Trevithick, JR (1999) Is ethanol an important antioxidant in alcoholic beverages associated with risk reduction of cataract and atherosclerosis? Redox Report 4, 89–93.CrossRefGoogle ScholarPubMed
van de Wiel, A, van Golde, PM, Kraaijenhagen, RJ, von dem Borne, PAK, Bouma, BN & Hart, HC (2001) Acute inhibitory effect of alcohol on fibrinolysis. European Journal of Clinical Investigation 31, 164–170.CrossRefGoogle ScholarPubMed
van der Gaag, MS, Ubbink, JB, Sillanaukee, P, Nikkari, S & Hendriks, HFJ (2000 a) Effect of consumption of red wine, spirits, and beer on serum homocysteine. Lancet 355. 1522.CrossRefGoogle ScholarPubMed
van der Gaag, MS, van den Berg, R, van den Berg, H, Schaafsma, G & Hendriks, HFJ (2000) Moderate consumption of beer, red wine and spirits has counteracting effects on plasma antioxidants in middle-aged men. European Journal of Clinical Nutrition 54, 586–591.CrossRefGoogle ScholarPubMed
van Golde, PHM, Sloots, LM, Vermeulen, WP, Wielders, JPM, Hart, HC, Bouma, BN & van de Wiel, A (1999) The role of alcohol in the anti low density lipoprotein oxidation activity of red wine. Atherosclerosis 147, 365–370.CrossRefGoogle ScholarPubMed
van Leer, EM, Seidell, JC & Kromhout, D (1994) Differences in the association between alcohol consumption and blood pressure by age, gender, and smoking. Epidemiology 5, 576–582.CrossRefGoogle ScholarPubMed
Van Tol, A, Groener, JE, Scheek, LM, Van Gent, T, Veenstra, J, Van de Pol, H, Hendriks, HF & Schaafsma, G (1995) Induction of net mass lipid transfer reactions in plasma by wine consumption with dinner. European Journal of Clinical Investigation 25, 390–395.Google ScholarPubMed
Veenstra, J, Kluft, C, Ockhuizen, TH, Pol, H, Wedel, M & Schaafsma, G (1990) Effects of moderate alcohol consumption on platelet function, tissue-type and plasminogen activator inhibitor. Thrombosis and Haemostasis 63, 345–348.Google ScholarPubMed
Veenstra, J, Ockhuizen, T, van de Pol, H, Wedel, M & Schaafsma, G (1990) Effects of a moderate dose of alcohol on blood lipids and lipoproteins postprandially and in the fasting state. Alcohol and Alcoholism 25, 371–377.Google ScholarPubMed
Venkov, CD, Myers, PR, Tanner, MA, Su, M & Vaughan, DE (1999) Ethanol increases endothelial nitric oxide production through modulation of nitric oxide synthase expression. Thrombosis and Haemostasis 81, 638–642.Google ScholarPubMed
Vermeulen, EGJ, Stehouwer, CDA, Twisk, JWR, van den Berg, M, de Jong, SC, Mackaay, AJC, van Campen, CMC, Visser, FC, Jakobs, CAJM, Bulterijs, EJ & Rauwerda, JA (2000) Effect of homocysteine-lowering treatment with folic acid plus vitamin B6 on progression of subclinical atherosclerosis: a randomised, placebo-controlled trial. Lancet 355, 517–522.CrossRefGoogle ScholarPubMed
Vinson, JA, Jang, J, Yang, J, Dabbagh, Y, Liang, X, Serry, M, Proch, J & Cai, S (1999) Vitamins and especially flavonoids in common beverages are powerful in vitro antioxidants which enrich lower density lipoproteins and increase their oxidative resistance after ex vivo spiking in human plasma. Journal of Agricultural and Food Chemistry 47, 2502–2504.CrossRefGoogle ScholarPubMed
Wannamethee, G & Shaper, AG (1992) Alcohol and sudden cardiac death. British Heart Journal 68, 443–448.CrossRefGoogle ScholarPubMed
Wannamethee, SG & Shaper, AG (1999) Type of alcoholic drink and risk of major coronary heart disease events and all-cause mortality. American Journal of Public Health 89, 685–690.CrossRefGoogle ScholarPubMed
Wannamethee, G, Whincup, PH, Shaper, AG, Walker, M & MacFarlane, PW (1995) Factors determining case fatality in myocardial infarction. British Heart Journal 74, 324–331.CrossRefGoogle ScholarPubMed
Whitehead, TP, Robinson, D, Allaway, S, Syms, J & Hale, A (1995) Effect of red wine ingestion on the antioxidant capacity of serum. Clinical Chemistry 41, 32–35.CrossRefGoogle ScholarPubMed
Witteman, JC, Willet, WC, Stampfer, MJ, Colditz, GA, Kok, FJ, Sacks, FM, Speizer, FE, Rosner, B & Hennekens, CH (1990) Relation of moderate alcohol consumption and risk of systemic hypertension in women. American Journal of Cardiology 65, 633–637.CrossRefGoogle ScholarPubMed
Witztum, JL & Hörkkö, S (1997) The role of oxidized LDL in atherogenesis: Immunological response and anti-phospholipid antibodies. Annals of the New York Academy of Sciences 811, 88–96.CrossRefGoogle ScholarPubMed
Woo, KS, Chook, P, Lolin, YI, Cheung, ASP, Chan, RN, Sun, YY, Sanderson, JE, Metreweli, C & Celermajer, DS (1997) Hyperhomocyst(e)inemia is a risk factor for arterial endothelial dysfunction in humans. Circulation 96, 2542–2544.CrossRefGoogle ScholarPubMed
Xia, J, Allenbrand, B & Sun, GY (1998) Dietary supplementation of grape polyphenols and chronic ethanol administration on LDL oxidation and platelet function in rats. Life Science 63, 383–390.CrossRefGoogle ScholarPubMed
Yamamoto, M, Egusa, G, Hara, H & Yamakido, M (1997) Association of intraabdominal fat and carotid atherosclerosis in non-obese middle-aged men with normal glucose tolerance. International Journal of Obesity and Related Disorders 21, 948–951.CrossRefGoogle ScholarPubMed
Zhang, QH, Das, K, Siddiqui, S & Myers, AK (2000) Effects of acute, moderate ethanol consumption on human platelet aggregation in platelet-rich plasma and whole blood. Alcoholism, Clinical and Experimental Research 24, 528–534.Google ScholarPubMed