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Synaptic plasticity-associated proteases and protease inhibitors in the brain linked to the processing of extracellular matrix and cell adhesion molecules

Published online by Cambridge University Press:  13 August 2009

Tet Woo Lee ,
Vicky W.K. Tsang  and
Nigel P. Birch
Tet Woo Lee
Affiliation:
School of Biological Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand
Vicky W.K. Tsang
Affiliation:
School of Biological Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand
Nigel P. Birch*
Affiliation:
School of Biological Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand
*
Correspondence should be addressed to: Nigel P. Birch, School of Biological Sciences, Level 2 Thomas BuildingUniversity of Auckland, Private Bag 92019, Auckland 1010, New Zealand phone: +64 9 373 7599 ex 88239 fax: +64 9 373 7414 email: [email protected]
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Abstract

Research on the molecular and cellular basis of learning and memory has focused on the mechanisms that underlie the induction and expression of synaptic plasticity. There is increasing evidence that structural changes at the synapse are associated with synaptic plasticity and that extracellular matrix (ECM) components and cell adhesion molecules are associated with these changes. The functions of both groups of molecules can be regulated by proteolysis. In this article we review the roles of selected proteases and protease inhibitors in perisynaptic proteolysis of the ECM and synaptic adhesion proteins and the impact of proteolysis on synaptic modification and cognitive function.

Keywords

Perisynaptic proteolysismetalloproteasesecretasetissue plasminogen activator (tPA)serpin
Type
Research Article
Information
Neuron Glia Biology , Volume 4 , Special Issue 3: Cell Adhesion and Extracellular Matrix Molecules in Synaptic Plasticity , August 2008 , pp. 223 - 234
Copyright
Copyright © Cambridge University Press 2009

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