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Glial differentiation and the Gcm pathway

Published online by Cambridge University Press:  13 April 2007

Laurent Soustelle  and
Angela Giangrande
Laurent Soustelle
Affiliation:
Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP, B.P.10142, 67404 Illkirch Cedex, C.U. de Strasbourg, France
Angela Giangrande*
Affiliation:
Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP, B.P.10142, 67404 Illkirch Cedex, C.U. de Strasbourg, France
*
*Correspondence should be addressed to Angela Giangrande, Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP, B.P.10142, 67404 Illkirch Cedex, C.U. de Strasbourg, France phone: +33 388653381 fax: +33 388653201 email: [email protected]
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Abstract

One of the most challenging issues in developmental biology is to understand how cell diversity is generated. The Drosophila nervous system provides a model of choice for unraveling this process. First, many neural stem cells and lineages have been identified. Second, major molecular pathways involved in neural development and associated mutations have been characterized extensively in recent years. In this review, we focus on the cellular and molecular mechanisms underlying the generation of glia. This cell population relies on the expression of gcm fate determinant, which is necessary and sufficient to induce glial differentiation. We also discuss the recently identified role of gcm genes in Drosophila melanogaster and vertebrate neurogenesis. Finally, we will consider the Gcm pathway in the context of neural stem cell differentiation.

Keywords

Glide/Gcmneurogenesisgliogenesisneural stem cellsspecification
Type
Research Article
Information
Neuron Glia Biology , Volume 3 , Issue 1 , February 2007 , pp. 5 - 16
Copyright
Copyright © Cambridge University Press 2007

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