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Can satellite glial cells be therapeutic targets for pain control?

Published online by Cambridge University Press:  22 June 2010

Luc Jasmin ,
Jean-Philippe Vit ,
Aditi Bhargava  and
Peter T. Ohara
Luc Jasmin*
Affiliation:
Department of Anatomy, University of California, San Francisco, CA, USA Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA
Jean-Philippe Vit
Affiliation:
Department of Psychiatry, Cedars-Sinai Medical Center, Los Angeles, CA, USA
Aditi Bhargava
Affiliation:
Department of Surgery, University of California, San Francisco, CA, USA
Peter T. Ohara
Affiliation:
Department of Anatomy, University of California, San Francisco, CA, USA
*
Correspondence should be addressed to: Luc Jasmin, Department of Anatomy, University of California, San Francisco, 513 Parnassus Avenue San Francisco, CA 94143-0452, USA phone: (415) 476-3761 fax: (415) 476-4845 email: [email protected]
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Abstract

Satellite glial cells (SGCs) undergo phenotypic changes and divide the following injury into a peripheral nerve. Nerve injury, also elicits an immune response and several antigen-presenting cells are found in close proximity to SGCs. Silencing SCG-specific molecules involved in intercellular transport (Connexin 43) or glutamate recycling (glutamine synthase) can dramatically alter nociceptive responses of normal and nerve-injured rats. Transducing SGCs with glutamic acid decarboxylase can produce analgesia in models of trigeminal pain. Taken together these data suggest that SGCs may play a role in the genesis or maintenance of pain and open a range of new possibilities for curing neuropathic pain.

Keywords

Nociceptiontrigeminalimmune cellsGABARNAi
Type
Research Article
Information
Neuron Glia Biology , Volume 6 , Special Issue 1: Satellite Glial Cells , February 2010 , pp. 63 - 71
Copyright
Copyright © Cambridge University Press 2010

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