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Bidirectional signaling of ErbB and Eph receptors at synapses

Published online by Cambridge University Press:  29 September 2009

Yu Chen ,
Amy K.Y. Fu  and
Nancy Y. Ip
Yu Chen
Affiliation:
Department of Biochemistry, Molecular Neuroscience Center and Biotechnology Research Institute, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China
Amy K.Y. Fu
Affiliation:
Department of Biochemistry, Molecular Neuroscience Center and Biotechnology Research Institute, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China
Nancy Y. Ip*
Affiliation:
Department of Biochemistry, Molecular Neuroscience Center and Biotechnology Research Institute, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China
*
Correspondence should be addressed to: Nancy Y. IP, Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China phone: 852-2358-7289 fax: 852-2358-2765 email: [email protected]
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Abstract

Synapse development and remodeling are regulated by a plethora of molecules such as receptor tyrosine kinases (RTKs), a family of cell surface receptors that play critical roles in neural development. Two families of RTKs implicated in synaptic functions, ErbBs and Ephs, share similar characteristics in terms of exhibiting forward and reverse signaling. In this review, we will discuss the latest advances in the functions of ErbBs and Ephs at the synapse, including dendritic spine morphogenesis, synapse formation and maturation, and synaptic transmission and plasticity. In addition to signaling at interneuronal synapses, communication between neuron and glia is increasingly implicated in the control of synaptic functions. Studies on RTKs and their cognate ligands in glial cells enhance our understanding on the nature of ‘tripartite synapse’. Implications of these signaling events in human diseases will be discussed.

Keywords

Neuregulinephringliadendritic spinesynaptic plasticity
Type
Research Article
Information
Neuron Glia Biology , Volume 4 , Special Issue 3: Cell Adhesion and Extracellular Matrix Molecules in Synaptic Plasticity , August 2008 , pp. 211 - 221
Copyright
Copyright © Cambridge University Press 2009

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