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Stimulation of taxol production in liquid cultures of Pestalotiopsis microspora

Published online by Cambridge University Press:  01 April 1998

JIA-YAO LI ,
RAJINDER S. SIDHU ,
ART BOLLON  and
GARY A. STROBEL
JIA-YAO LI
Affiliation:
Department of Plant Pathology, Montana State University, Bozeman, MT 59717, U.S.A.
RAJINDER S. SIDHU
Affiliation:
Cytoclonal Pharmaceutics, 9000 Harry Hines Blvd, Dallas, Texas 75235, U.S.A.
ART BOLLON
Affiliation:
Cytoclonal Pharmaceutics, 9000 Harry Hines Blvd, Dallas, Texas 75235, U.S.A.
GARY A. STROBEL
Affiliation:
Department of Plant Pathology, Montana State University, Bozeman, MT 59717, U.S.A.
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Abstract

Pestalotiopsis microspora is an endophyte associated with many plants including Taxus wallachiana. Isolates commonly produce taxol in liquid culture. Defining culture amendments to optimize taxol production by P. microspora is a critical step toward the realization of fungal taxol for treating human cancers. The lowering of phosphate and the addition of sodium benzoate in the medium increased taxol production. Sterol biosynthesis inhibitors, such as tebuconazole and triadimefon, dramatically increased taxol yields.

Type
Research Article
Information
Mycological Research , Volume 102 , Issue 4 , April 1998 , pp. 461 - 464
Copyright
The British Mycological Society 1998

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