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Unique Microstructure and Mechanical Properties from Melt Processing Poly(Lactide-co-Glycolide)/Poly(Trimethylene Carbonate)

Published online by Cambridge University Press:  31 January 2011

Jianbin Zhang ,
Lian Luo ,
Suping Lyu ,
Bryant Pudil ,
Jim Schley ,
Mike Benz ,
Adam Buckalew ,
Kim Chaffin ,
Chris Hobot  and
Randy Sparer
Jianbin Zhang
Affiliation:
[email protected], Medtronic Inc., Medtronic Strategy and Innovation, Minneapolis, Minnesota, United States
Lian Luo
Affiliation:
[email protected], Medtronic Inc., Medtronic Strategy and Innovation, Minneapolis, Minnesota, United States
Suping Lyu
Affiliation:
[email protected], Medtronic Inc., Medtronic Strategy and Innovation, Minneapolis, Minnesota, United States
Bryant Pudil
Affiliation:
[email protected], Medtronic Inc., Medtronic Strategy and Innovation, Minneapolis, Minnesota, United States
Jim Schley
Affiliation:
[email protected], Medtronic Inc., Medtronic Strategy and Innovation, Minneapolis, Minnesota, United States
Mike Benz
Affiliation:
[email protected], Medtronic Inc., Medtronic Strategy and Innovation, Minneapolis, Minnesota, United States
Adam Buckalew
Affiliation:
[email protected], Medtronic Inc., Medtronic Strategy and Innovation, Minneapolis, Minnesota, United States
Kim Chaffin
Affiliation:
[email protected], Medtronic Inc., Medtronic Strategy and Innovation, Minneapolis, Minnesota, United States
Chris Hobot
Affiliation:
[email protected], Medtronic Inc., Medtronic Strategy and Innovation, Minneapolis, Minnesota, United States
Randy Sparer
Affiliation:
[email protected], Medtronic Inc., Medtronic Strategy and Innovation, Minneapolis, Minnesota, United States
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Abstract

Poly(lactide) (PLA) and its copolymers degrade through hydrolysis into non-toxic and water soluble metabolic products in vivo. They are ideal materials for resorbable biomedical applications such as drug delivery and tissue engineering. However, these polymers are brittle and often need to be toughened. One of the most effective toughening methods is reactive blending, in which additives are dispersed into polymer matrices as small particles with strong bonding between the two materials. In this paper, we studied toughening poly(lactide-co-glycolide) (PLGA) through reactive blending with poly(trimethylene carbonate) (PTMC). We observed warm-like micelle or swollen warm-like micelle structures created during the reactive blending process with a twin screw extruder at high temperature. The micelle structures were orientated along the extrusion direction with their length ranging from 50 to 1000 nm and diameters about 50 nm. This structure could be produced only with a twin screw extruder. When a batch mixer was used, the PTMC additive (10 to 30 wt%) formed spheres with diameters on the order of 100-500 nm. The PLGA/PTMC copolymers formed in situ were responsible to this microstructure. The mechanical properties of this blend were significantly improved over the pure PLGA.

Keywords

biomaterialmicrostructuretoughness
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1239: Symposium VV – Micro- and Nanoscale Processing of Biomaterials , 2009 , 1239-VV01-10
Copyright
Copyright © Materials Research Society 2010

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References

1 Kulkarni, R. K.; Pani, K. C.; Neuman, C.; Leonard, F. Arch. Surg 1966, 93, 839.Google Scholar
2 Vainionpaa, S.; Rokkanen, P.; Tormala, P. Prog. Polym. Sci. 1989, 14.Google Scholar
3 Middleton, J. C.; Tipton, A. J. Med. Plast. Biomat. 1998, 30, 8.Google Scholar
4 Panyama, J.; Labhasetwar, V. Adv. Drug Deliv. Rev. 2002, 55, 329.Google Scholar
5 Liu, C. Z.; Czernuszka, J. T. Materials Science and Technology 2007, 23, 379.Google Scholar
6 Wu, S. Polym. Intl. 1992, 29, 229 Google Scholar
7 Lyu, S.; Zhu, X.; Qi, Z. J. Polym. Res. 1995, 2, 217 Google Scholar
8 Anderson, K. S.; Schreck, K. M.; Hillmyer, M. A. Polym. Rev. 2008, 48, 85.Google Scholar
9 Crijpma, D. W.; Van Hofslot, R. D. A.; Super, H.; Nihenhuis, A. J.; Pennings, A. J. Polym. Eng. Sci. 1994, 34, 1674.Google Scholar
10 Zhang, J.; Luo, L.; Lyu, S.; Schley, J.; Pudil, B.; Benz, M.; Buckalew, A.; Chaffin, K.; Hobot, C.; Sparer, R. J Appl. Polym. Sci. accepted. Google Scholar
11 Thio, Y. S.; Wu, J.; Bates, B. S. Macromolecules 2006, 39, 7187 Google Scholar
12 Zhang, J.; Lyu, S.; Pudil, B.; Luo, L.; Buckalew, A. et al. , to be submittedGoogle Scholar