Hostname: page-component-586b7cd67f-dlnhk Total loading time: 0 Render date: 2024-11-24T18:22:30.240Z Has data issue: false hasContentIssue false
  • English
  • Français

Tuning Mechanical Properties of Chondroitin Sulfate-Based Hydrogels Using the Double-Network Strategy

Published online by Cambridge University Press:  22 January 2014

Tiffany C Suekama ,
Anahita Khanlari  and
Stevin H Gehrke
Tiffany C Suekama
Affiliation:
Chemical & Petroleum Engineering, University of Kansas, Lawrence, KS, United States
Anahita Khanlari
Affiliation:
Chemical & Petroleum Engineering, University of Kansas, Lawrence, KS, United States
Stevin H Gehrke
Affiliation:
Chemical & Petroleum Engineering, University of Kansas, Lawrence, KS, United States
Get access

Abstract

The double-network (DN) hydrogel concept developed by J.P. Gong and Y. Osada builds upon interpenetrating networks by combining brittle and ductile components to have significantly enhanced fracture properties. The generality of the DN effect was tested by creating biopolymer-based hydrogels of methacrylated chondroitin sulfate (MCS) and polyacrylamide (PAAm) and extended upon creating DNs of MCS and poly(N,N dimethyl acrylamide) (PDMAAm), verifying that DNs were not limited to the original combination of poly(2-acrylamido-2-methylpropanesulfonic acid) (PAMPS)/polyacrylamide (PAAm). Further, the mechanical properties were varied by changing the monomer concentrations, cross-linker concentrations and the addition of cross-linking groups through copolymerizations of MCS and poly(ethylene glycol) diacrylate (PEGDA). Overall, this work demonstrates that a broad range of mechanical properties achievable through DN effect under tension and compression, generally independent of the swelling degree, which is fundamentally different behavior than possible with single networks.

Keywords

polymerbiomaterialstress/strain relationship
Type
Articles
Information
MRS Online Proceedings Library (OPL) , Volume 1622: Symposium E – Fundamentals of Gels and Self-Assembled Polymer Systems , 2014 , pp. 79 - 84
Copyright
Copyright © Materials Research Society 2014 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Gong, J. P., Soft Matter 6, 2583–2590 (2010).CrossRefGoogle Scholar
Li, Q., Wang, D. and Elisseeff, J. H., Macromolecules 36, 2556–2562 (2003).CrossRefGoogle Scholar
Mow, V. C., Ratcliffe, A. and Robin Poole, A., Biomaterials 13, 67–97 (1992).CrossRefGoogle Scholar
Li, Q., Williams, C. G., Sun, D. N., Wang, J., Leong, K. and Elisseeff, J. H., Journal of Biomedical Materials Research 68, 28–33 (2004).CrossRefGoogle Scholar
Suekama, T. C., Hu, J., Kurokawa, T., Gong, J. P. and Gehrke, S. H., ACS Macro Letters 2, 137–140 (2013).CrossRefGoogle Scholar
Ingavle, G., Dormer, N., Gehrke, S. and Detamore, M., Journal of Materials Science: Materials in Medicine 23, 157–170 (2012).Google Scholar
Steinmetz, N. J. and Bryant, S. J., Biotechnology and Bioengineering, 109, 2671–2682 (2012).CrossRefGoogle Scholar
Suekama, T. C., Hu, J., Kurokawa, T., Gong, J. P. and Gehrke, S. H., Macromolecular Symposia 329, 9–18 (2013).CrossRefGoogle Scholar
Khanlari, A., Detamore, M. S. and Gehrke, S. H., Macromolecules, 46, 9609–9617 (2013).CrossRefGoogle Scholar
Liang, S., Wu, Z. L., Hu, J., Kurokawa, T., Yu, Q. M. and Gong, J. P., Macromolecules 44, 3016–3020 (2011).CrossRefGoogle Scholar
Yu, Q. M., Tanaka, Y., Furukawa, H., Kurokawa, T. and Gong, J. P., Macromolecules 42, 3852–3855 (2009).CrossRefGoogle Scholar
Hu, J., Hiwatashi, K., Kurokawa, T., Liang, S. M., Wu, Z. L. and Gong, J. P., Macromolecules 44, 7775–7781 (2011).CrossRefGoogle Scholar
Peppas, N., Hydrogels in Medicine and Pharmacy, CRC Press Boca Raton, FL, CRC Press Boca Raton, FL, (1988).Google Scholar
Gehrke, S. H., in Transport in Pharmaceutical Sciences, eds. Amidon, G. L., Lee, P. I. and Topp, E. M., Marcel Dekker, New York, NY, 2000, pp. 473–546.Google Scholar
Suekama, T. C., Rennerfeldt, D., Khanlari, A. and Gehrke, S. H., Manuscript in preparation Google Scholar
Calvert, P., Advanced Materials 21, 743–756 (2009).CrossRefGoogle Scholar
Na, Y. H., Tanaka, Y., Kawauchi, Y., Furukawa, H., Sumiyoshi, T., Gong, J. P. and Osada, Y., Macromolecules 39, 4641–4645 (2006).CrossRefGoogle Scholar
Haque, M. A., Kurokawa, T. and Gong, J. P., Polymer 53, 1805–1822 (2012).CrossRefGoogle Scholar
Kawauchi, Y., Tanaka, Y., Furukawa, H., Kurokawa, T., Nakajima, T., Osada, Y. and Gong, J. P., J. Phys. Conf. Ser., 184, 012016 (2009).CrossRefGoogle Scholar
Abraham, G. A., de Queiroz, A. A. and Román, J. S., Biomaterials 22, 1971–1985 (2001).CrossRefGoogle Scholar