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Synthesis and characterization of functionalized nano magnetite with phthalocyanines for use in photodynamic therapy

Published online by Cambridge University Press:  14 April 2016

M.A. Balcázar-Pérez ,
G. Ramírez-García ,
S. Gutiérrez  and
R. Galindo
M.A. Balcázar-Pérez
Affiliation:
División de Ciencias Naturales y Exactas, Campus Guanajuato, Universidad de Guanajuato, Cerro de la Venada s/n, Pueblito de Rocha, C.P. 36040 Guanajuato, Gto, Mexico.
G. Ramírez-García
Affiliation:
División de Ciencias Naturales y Exactas, Campus Guanajuato, Universidad de Guanajuato, Cerro de la Venada s/n, Pueblito de Rocha, C.P. 36040 Guanajuato, Gto, Mexico.
S. Gutiérrez
Affiliation:
División de Ciencias Naturales y Exactas, Campus Guanajuato, Universidad de Guanajuato, Cerro de la Venada s/n, Pueblito de Rocha, C.P. 36040 Guanajuato, Gto, Mexico.
R. Galindo
Affiliation:
División de Ciencias Naturales y Exactas, Campus Guanajuato, Universidad de Guanajuato, Cerro de la Venada s/n, Pueblito de Rocha, C.P. 36040 Guanajuato, Gto, Mexico. Consejo Nacional de Ciencia y Tecnología, Av. Insurgentes Sur 1582, Benito Juárez, Crédito Constructor, C.P 03940 Ciudad de México, D.F.
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Abstract

Magnetic nanoparticles (MNPs) are a class of materials that can be manipulated under the influence of an external magnetic field. Thanks to the ability of the MNPs to be guided by an external magnetic field that is like "action at a distance", combined with their low cytotoxicity and the intrinsic penetrability of magnetic fields into human tissue, opens up many applications involving the transport and/or immobilization of biological entities [1, 2].

This work is focused on the synthesis of magnetite nanoparticles by varied methods, their functionalization with nickel tetrasulfonated phthalocyanine, and the corresponding physicochemical characterization and colloidal stability studies in biologically compatible media. The in vitro production of singlet oxygen by these nanoparticles through photochemical stimulation in ultraviolet and visible region was evaluated, resulting in 4.5 and 4 µM respectly to magnetite synthetized in the group. The increase reactive oxygen species concentration in the cellular environment can result in modification and damage of cellular components, and potentially, cell death and necrosis. Therefore, these materials offer the promise of revolutionary tools for photodynamic therapy and hyperthermia, which are attractive strategies for cancer therapy without systemic toxicity.

Keywords

FeMagneticBiofunctionalization
Type
Articles
Information
MRS Online Proceedings Library (OPL) , Volume 1817: Symposium 1D – Nanostructured Materials and Nanotechnology—2015 , 2016 , imrc2015abs275
Copyright
Copyright © Materials Research Society 2016 

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