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Study for the Interfacial Effect between a Crawling Cell and a Substrate on Chemotaxis

Published online by Cambridge University Press:  10 March 2011

Jihwan Song  and
Dongchoul Kim
Jihwan Song
Affiliation:
Department of Mechanical Engineering, Sogang University, 1 Shinsoo-dong, Mapo-go, Seoul, Republic of Korea
Dongchoul Kim
Affiliation:
Department of Mechanical Engineering, Sogang University, 1 Shinsoo-dong, Mapo-go, Seoul, Republic of Korea
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Abstract

Chemotaxis is one of the essential mechanisms responsible for various complex biological processes. For a crawling cell, the interface between the cell and the substrate plays an important role in the chemotactic migration. This paper presents a three-dimensional dynamic model to investigate the effect of the interface between a crawling cell and a substrate on its chemotaxis. The coupled mechanisms of chemotaxis, the surface energy of the cell, and the interface between the cell and the substrate are incorporated into a diffuse interface model. Simulations reveal rich dynamics of a crawling cell associated with the interfacial condition, and confirm the high possibility of adequate predictions.

Keywords

biologicalsimulationdiffusion
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1301: Symposium V/NN/OO/PP – Soft Matter, Biological Materials and Biomedical Materials—Synthesis, Characterization and Applications , 2011 , mrsf10-1301-oo15-06
Copyright
Copyright © Materials Research Society 2011

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