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Self-Assembly of Tyrocidines in Nanotubular Structures

Published online by Cambridge University Press:  15 February 2011

M. Thies  and
H. H. Paradies
M. Thies
Affiliation:
Biotechnology & Physical Chemistry, Mirkische Fachhochschule, Iserlohn, D-58644 Germany, [email protected]
H. H. Paradies
Affiliation:
Biotechnology & Physical Chemistry, Mirkische Fachhochschule, Iserlohn, D-58644 Germany, [email protected] University of Paderbom, Fachbereich Chemie & Chemietechnik, Paderborn, D-33095, Germany.
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Abstract

Hollow tubular structures of tyrocidines, a cyclic decapeptide with two amino acids residues in the D-configuration and eight in the L-configuration, were formed in acid aqueous solutions in the presence of ethanol (20°C). Discrete nanotubes can be produced under controlled conditions, e.g. the amount of water added, or in the presence of protons from ethanol-water solutions (45/55 %v/v). These cyclic oligopeptides crystallize into tubular structures hundreds of nanometer long with an internal diameter of 9.0 Å and outer diameter of 35 Å. Support for the proposed tubular structure is provided by electronmicroscopy, SAXS and Fourier-transform infrared spectroscopy. These structures are open-ended, having a uniform shape and constant internal diameter.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 489: Symposium K – Materials Science of the Cell , 1997 , 145
Copyright
Copyright © Materials Research Society 1998

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References

[1] Iijima, S., Nature, 354, 55, (1991).Google Scholar
[2] a.) Clark, T. D., Ghadiri, M.R., J. Amer. Chem. Soc., 117, 12364, (1995); b.) M.R. Ghadiri et al., Nature, 366, 324, (1993).Google Scholar
[3] Ebbesen, T.W., Alayan, P.M., Nature, 358, 220, (1992).Google Scholar
[4] Crooke, S.T., Lebleu, B., Antisense Research and Applications, CRC Press Inc., 149–187, (1993); A.R. Thierry, A. Raman, A. Dritschilo, in Gene Regulation: Biology of Antisense RNA and DNA, R. P. Erickson, J.G. Izant, eds., 147, Raven Press, N.Y., (1992); P.L. Feigner, G.M. Ringold, Nature, 337, 387, (1989); M.Y. Chiang et al., J. Biol. Chem., 266, 18162, (1991); C.F. Bennett et al., Biochem. Pharmacol., 41, 1023, (1992); B. Oberhauser, E. Wagner, Nucleic Acids Res., 20, 533, (1992).Google Scholar
[5] Whitesides, G.M. et al., Acc. Chem. Res., 28, 37–44, (1995); M.R. Ghadiri et al., Adv. Mater., 7, 675, (1995); J.R. Granja, M.R.Ghadiri, J. Amer. Chem. Soc., 116, 10785, (1994); M.R. Ghadiri, J.R. Granja, L. Buehler, Nature, 369, 301, (1994). N. Khazanovich et al., J. Amer. Chem. Soc., 116, 6011, (1994).Google Scholar
[6] lzumija, N. et al., in Synthetic Aspects of Biologically Active Cyclic Peptides-Gramicidin S and Tyrocidines-. A Halsted Press Book, Kodansha Ltd, John Wiley & Sons, N.Y. (1979); H. Ristow et al., Nature, 280, 165, (1979); H. Ristow et al., Eur. J. Biochem., 129, 395, (1982); W. Pshom et al., Eur. J. Biochem., 395, 403, (1982); W. Danders et al., Antimicrob. Ag. Chemother., 22, 785, (1982); E. Katz, A.L., Lemain, Bacteriol. Rev., 41, 499474, (1977).Google Scholar
[7] H.H. Paradies, US-Patent # 4, 874,850, (1989); Paradies, H.H., Schroer, U., Pharm. Ind., 12, 1387, (1989).Google Scholar
[8] Paradies, H.H., J. Pharm. Sci., 8, 230, (1989).Google Scholar
[9] Paradies, H.H., J. Biol. Chem., 254, 7495, (1979).Google Scholar
[10] Paradies, H.H., J.Phys.Chem., 84, 599, (1989); H.H. Paradies, M. Thies, Bunsen Ges. Phys.Chem., 98, 715, (1994).Google Scholar
[11] Porod, G., Kolloid-Zeitschrift, 15, 84, (1951).Google Scholar
[12] Paradies, H. H. et al., submitted to J. Phys. Chem.(1997).Google Scholar
[13] Krimm, S., Bandekar, J., in Advances in Protein Chemistry (eds. Anfinsen, C.B., Edsall, J.T., Richards, F.M.), 181–364, Academic, Orlando, (1986).Google Scholar
[14] Langs, D.A., Science, 241, 188, (1988); B.A.Wallace, K. Ravikunar, Science, 241, 182, (1988).Google Scholar
[15] Naik, V. M., Krimm, S., Biophys. J., 49, 1147, (1986).Google Scholar
[16] Urry, D.W. et al., Antimicrob. Agents Chemother., 87, (1968).Google Scholar
[17] Stem, A. et al., J. Amer. Chem. Soc., 91, 2794, (1996); H. H. Paradies, Biochem. Biophys. Comm., 88, 810, (1979).Google Scholar
[18] Paradies, H.H., J.Phys.Chem., 90, (1986); M. Thies, H.H.Paradies, S. F. Clancy, Mat. Res. Soc. Symp., Vol.463, 115, (1997); H. H. Paradies, Medicinale, 14, 1–13, (1984).Google Scholar