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Reconstituted Collagen Produces Different Healing Reactions in Bony and Soft Tissue Compartments

Published online by Cambridge University Press:  15 February 2011

Reynaldo Todescan  and
Johne E. Davies
Reynaldo Todescan
Affiliation:
Centre for Biomaterials, University of Toronto, 170 College Street, Toronto, ON, M5S 1A1, Canada.
Johne E. Davies
Affiliation:
Centre for Biomaterials, University of Toronto, 170 College Street, Toronto, ON, M5S 1A1, Canada.
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Abstract

Using both in vivo and in vitro experiments we have demonstrated that: reconstituted collagen will undergo mineralization in a healing bony compartment; that this mineralization is the result of spontaneous precipitation of calcium salts due to the presence of alkaline phosphatase produced by the bone cells, and that once calcified, the collagen will undergo cellular resorption by tartrate-resistant multi-nucleate giant cells similar to osteoclasts. This sequence of events is quite different to that in the supra-bony soft-tissue compartment where no calcification of the collagen is apparent, the collagen matrix becomes infiltrated with fibroblast-like cells and little resorption of the matrix occurs during implantation.

We conclude that reconstituted collagen may be employed as both a tissue barrier, enhancing guided tissue regeneration, and a bone-substitute material, which becomes replaced by natural bone tissue.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 252: Symposium T – Tissue-Inducing Biomaterials , 1991 , 159
Copyright
Copyright © Materials Research Society 1992

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References

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