Hostname: page-component-586b7cd67f-vdxz6 Total loading time: 0 Render date: 2024-11-24T11:10:04.206Z Has data issue: false hasContentIssue false
  • English
  • Français

Poly(n-butylcyanoacrylate) Nanoparticles as Carriers for Adenosine triphosphate

Published online by Cambridge University Press:  06 February 2015

Christian Wischke ,
Judith Weigel  and
Andreas Lendlein
Christian Wischke
Affiliation:
Institute of Biomaterial Science and Berlin-Brandenburg Center for Regenerative Therapies, Kantstr. 55, 14513 Teltow, Germany
Judith Weigel
Affiliation:
Institute of Biomaterial Science and Berlin-Brandenburg Center for Regenerative Therapies, Kantstr. 55, 14513 Teltow, Germany
Andreas Lendlein
Affiliation:
Institute of Biomaterial Science and Berlin-Brandenburg Center for Regenerative Therapies, Kantstr. 55, 14513 Teltow, Germany
Get access

Abstract

Adenosine triphosphate (ATP) has numerous biological functions both intra- and extracellularly, including effects on the directed migration of cells with a regenerative potential in brain tissue. Therefore, carrier systems would be of interest that would be capable to be loaded with ATP and release it in a controlled manner. In the present study, poly(n-butylcyanoacrylate) (PBCA) nanoparticles as a potential carrier system were prepared by anionic polymerization using different polymerization media, which resulted in different zeta potential values and in some cases aggregation of nanoparticles. By decorating the particle surface with positively charged diethylaminoethyl dextran, multivalent ionic interaction allowed to load ATP to the nanoparticles by adsorption. In release experiments, an ATP release over 6 hours was observed. ATP-loaded nanoparticles may thus be suitable to explore biological effects of short-term ATP delivery for biomedical applications.

Keywords

adsorptionpolymerparticulate
Type
Articles
Information
MRS Online Proceedings Library (OPL) , Volume 1718: Symposium B – Multifunctional Polymeric and Hybrid Materials , 2015 , pp. 131 - 136
Copyright
Copyright © Materials Research Society 2015 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Farber, K., Markworth, S., Pannasch, U., Nolte, C., Prinz, V., Kronenberg, G., Gertz, K., Endres, M., Bechmann, I., Enjyoji, K., Robson, S.C. and Kettenmann, H., Glia 56, 331 (2008).CrossRefGoogle Scholar
Wischke, C., Weigel, J., Bulavina, L. and Lendlein, A., J. Controlled Release 195, 86 (2014).CrossRefGoogle Scholar
Du, Y.Z., Ying, X.Y., Wang, L., Zhai, Y., Yuan, H., Yu, R.S. and Hu, F.Q., Int. J. Pharm. 392, 164 (2010).CrossRefGoogle Scholar
Kurakhmaeva, K.B., Djindjikhashvili, I.A., Petrov, V.E., Balabanyan, V.U., Voronina, T.A., Trofimov, S.S., Kreuter, J., Gelperina, S., Begley, D. and Alyautdin, R.N., J. Drug Target. 17, 564 (2009).CrossRefGoogle Scholar
Zimmer, A., Methods 18, 286 (1999).CrossRefGoogle Scholar
Gibaud, S., Rousseau, C., Weingarten, C., Favier, R., Douay, L., Andreux, J.P. and Couvreur, P., J. Controlled Release 52, 131 (1998).CrossRefGoogle Scholar
Volonte, M.G., Yuln, G., Quiroga, P. and Consolini, A.E., J. Pharm. Biomed. Anal. 35, 647 (2004).CrossRefGoogle Scholar
Nicolas, J. and Couvreur, P., WIRES Nanomed. Nanobi. 1, 111 (2009).CrossRefGoogle Scholar