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Oligonuleotide Delivery with Dendritic Poly(L-lysine) for Treatments of the Liver Disorders
Published online by Cambridge University Press: 31 January 2011
Abstract
A cationic peptide dendrier, dendritic poly(L-lysine), forms complexes with oligonucleotides and can deliver them to liver after intravenous injection. Here, we tried to deliver apolipoprotein B-specific siRNA for the treatment of hypercholesterolemia and NFκB decoy for the hepatitis treatment. Significant therapeutic effects in those disease model mice were observed after intravenous injection of the oligonucleotides complexes with dendritic poly(L-lysine).
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