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Novel Gelation System For Fabricating 3-D Structures via Ink Jet Printing

Published online by Cambridge University Press:  31 January 2011

Rachel E. Saunders ,
Kwan P Liem ,
Robert J Mart ,
Simon J Webb  and
Brian Derby
Rachel E. Saunders
Affiliation:
[email protected]
Kwan P Liem
Affiliation:
[email protected], The University of Manchester, Manchester Interdisciplinary Biocentre and School of Chemistry, Manchester, United Kingdom
Robert J Mart
Affiliation:
[email protected], The University of Manchester, Manchester Interdisciplinary Biocentre and School of Chemistry, Manchester, United Kingdom
Simon J Webb
Affiliation:
[email protected], The University of Manchester, Manchester Interdisciplinary Biocentre and School of Chemistry, Manchester, United Kingdom
Brian Derby
Affiliation:
[email protected], University of Manchester, School of Materials, Grosvenor Street, Manchester, M1 7HS, United Kingdom
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Abstract

Drop-on-demand inkjet printing is a fabrication technique that is capable of depositing materials layer-by-layer to form complex 3-dimensional (3-D) constructs. Here we present a new single drop delivery method in which both the matrix and cross-linker are present but separated through the use of vesicle packaging. Changing the printing parameters has little effect on the integrity of the calcium(II)-loaded vesicles, with calcium(II) released selectively by warming after printing. Alginate solutions containing calcium(II)-loaded vesicles were successfully printed and the printed layers were shown to gel on demand at 37 °C. The printed alginate layers were evaluated with regards to their potential to provide 3-D structures for cell culture.

Keywords

ink-jet printingtissuepiezoelectric
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1239: Symposium VV – Micro- and Nanoscale Processing of Biomaterials , 2009 , 1239-VV06-10
Copyright
Copyright © Materials Research Society 2010

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