Hostname: page-component-78c5997874-t5tsf Total loading time: 0 Render date: 2024-11-02T21:22:59.032Z Has data issue: false hasContentIssue false
  • English
  • Français

Nanostructured Selenium for Preventing Biofilm Formation on Medical Devices

Published online by Cambridge University Press:  12 January 2012

Qi Wang  and
Thomas J. Webster
Qi Wang
Affiliation:
Department of Chemistry, Brown University, Providence, RI02906, U.S.A.
Thomas J. Webster
Affiliation:
School of Engineering, Brown University, Providence, RI02906, U.S.A.
Get access

Abstract

Biofilms are a common cause of persistent infections on medical devices as they are easy to form and hard to treat. Selenium and its compounds are considered to be a novel material for a wide range of applications including anticancer applications and antibacterial applications. The objective of this study was to coat selenium nanoparticles on the surface of polycarbonate medical devices and examine their effectiveness at preventing biofilm formation. The results of this in vitro study showed that the selenium coating significantly inhibited Staphylococcus aureus growth on the surface of polycarbonate after 24 hours. Thus, this study suggests that coating polymers with nanostructured selenium is a fast and effective way to reduce bacteria functions leading to medical device infections.

Keywords

biomaterialSepolymer
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1415: Symposium HH/II/TT – MEMS, BioMEMS and Bioelectronics–Materials and Devices , 2012 , mrsf11-1415-ii03-13
Copyright
Copyright © Materials Research Society 2012

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

1. Costerton, JW, Stewart, PS, Greenberg, EP. Bacterial biofilms: a common cause of persistent infections. Science. 1999;284(5418):1318–1322.Google Scholar
2. Institute of Medicine. To Err is Human Building a Safer Health System. Kohn, L, Corrigan, J, Donaldson, M, eds. 1999.Google Scholar
3. Singh, R, Ray, P, Das, A, Sharma, M. Role of persisters and small-colony variants in antibiotic resistance of planktonic and biofilm-associated Staphylococcus aureus: an in vitro study. J Med Microbiology. 2009;58(8):1067–1073.Google Scholar
4. Rayman, MP. Selenium in cancer prevention: a review of the evidence and mechanism of action. Proc Nutr Soc. 2005;64(4):527–542.Google Scholar
5. Clark, LC, Combs, GF Jr, Turnbull, BW, et al. . Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin. A randomized controlled trial. Nutritional Prevention of Cancer Study Group. JAMA. 1996;276(24):1957–1963.Google Scholar
6. Tran, PA, Webster, TJ. Selenium nanoparticles inhibit Staphlococcus aureus growth. International Journal of Nanomedicine. 2011:6 1553–1558.Google Scholar
7. Tran, PL, Hammond, AA, Mosley, T, et al. . An organo-selenium coating on cellulose inhibits Pseudomonas aeruginosa and stphylococcus aureus biofilm fomation. Appl Environ Microbiology. 2009;75(11):3586–3592.Google Scholar
8. Mittal, K. L., “Adhesion Measurement: Recent Progress, Unsolved Problems, and Prospects,” Adhesion Measurement of Thin Films, Thick Films, and Bulk Coatings, ASTM STP 640, ASTM, 1978, pp. 7–8.Google Scholar