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Morphologically Well-defined Gold Nanoparticles Embedded in Thermo-Responsive Hydrogel Matrices

Published online by Cambridge University Press:  15 March 2011

Chun Wang ,
Nolan T. Flynn  and
Robert Langer
Chun Wang
Affiliation:
Department of Chemical Engineering, Massachusetts Institute of Technology, E25-342, Cambridge, MA 02139, U.S.A.
Nolan T. Flynn
Affiliation:
Department of Chemical Engineering, Massachusetts Institute of Technology, E25-342, Cambridge, MA 02139, U.S.A.
Robert Langer*
Affiliation:
Department of Chemical Engineering, Massachusetts Institute of Technology, E25-342, Cambridge, MA 02139, U.S.A.
*
*Corresponding author: [email protected]
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Abstract

Nanocomposite materials consisting of colloidal gold (Au) nanoparticles embedded in thermo-responsive poly(N-isopropylacrylamide) (PNIPAm) hydrogels are synthesized. Thiol groups that bind to both Au3+ ions and colloidal Au are incorporated into the side-chains of the PNIPAm hydrogels through copolymerization. This report describes formation of morphologically well-defined Au nanoparticles with varying long-term stability inside the hydrogel matrices containing adjustable concentrations of thiols. Compared with the non-Au containing PNIPAm hydrogels, the Au-PNIPAm nanocomposite hydrogels have shown higher degrees of equilibrium swelling and different temperature-triggered phase transitions. It is hypothesized that these remarkable changes in hydrogel bulk properties are related to the different morphologies and sizes, and possibly the amount of surface charges, of the Au nanoparticles.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 820: Symposia O/R – Nanoengineered Assemblies and Advanced Micro/Nanosystems , 2004 , R2.2
Copyright
Copyright © Materials Research Society 2004

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