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Microfluidic Manifolds with High Dynamic Range in Structural Dimensions Replicated in Thermoplastic Materials

Published online by Cambridge University Press:  31 January 2011

Holger Becker ,
Erik Beckert  and
Claudia Gärtner
Holger Becker
Affiliation:
[email protected], microfluidic ChipShop GmbH, Carl-Zeiss-Promenade 10, Jena, 07745, Germany
Erik Beckert
Affiliation:
[email protected], Fraunhofer Institut für Angewandte Optik und Feinmechanik, Jena, Germany
Claudia Gärtner
Affiliation:
[email protected], microfluidic ChipShop GmbH, Jena, Germany
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Abstract

In this paper, we present the manufacturing process of a polymer microfluidic device which is currently being used to investigate wetting properties of nanostructured microchannels replicated in hydrophobic thermoplastic materials like cyclo-olefin co-polymer (COC), polypropylene (PP) or polymethylmetacrylate (PMMA). These devices feature large structural dynamics (feature sizes between 200 μm and 200 nm). The mold insert necessary was fabricated using a combination of precision machining with single-point diamond turning (SPDT).

Keywords

microelectro-mechanical (MEMS)nanostructurefluidics
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1191: Symposium OO – Materials and Strategies for Lab-on-a-Chip–Biological Analysis, Cell-Material Interfaces and Fluidic Assembly of Nanostructures , 2009 , 1191-OO02-01
Copyright
Copyright © Materials Research Society 2009

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References

[1] Kamahori, M. Ishige, Y. and Shimoda, M. “Enzyme Immunoassay Using a Reusable Extended-gate Field-Effect-Transistor Sensor with a Ferrocenylalkanethiol-modified Gold Electrode,” Analytical Sciences, vol. 24, pp. 1073–1079, 2008.10.2116/analsci.24.1073Google Scholar
[2] Goncalves, D. Prazeres, D. M. F. Chu, V. and Conde, J. P. “Detection of DNA and proteins using amorphous silicon ion-sensitive thin-film field effect transistors,” Biosensors and Bioelectronics, vol. 24, pp. 545–551, 2008.10.1016/j.bios.2008.05.006Google Scholar
[3] Migita, S. Ozasa, K. Tanaka, T. and Haruyama, T. “Enzyme-based Field-Effect Transistor for Adenosine Triphosphate (ATP) Sensing,” Analytical Sciences, vol. 23, p. 4, 2007.10.2116/analsci.23.45Google Scholar
[4] Kang, S. J. P. B. S., Chen, J. J. Ren, F., Johnson, J. W. Therrien, R. J. Rajagopal, P. Roberts, J. C., Piner, E. L. and Linthicum, K. J. “Electrical detection of deoxyribonucleic acid hybridization with AlGaN/GaN high electron mobility transistors,” Applied Physics Letters, vol. 89, pp. 122102–122104, 2006.10.1063/1.2354491Google Scholar
[5] Zhang, Q. and Subramanian, V. “DNA hybridization detection with organic thin film transistors: Toward fast and disposable DNA microarray chips,” Biosensors and Bioelectronics, vol. 22, pp. 3182–3187, 2007.10.1016/j.bios.2007.02.015Google Scholar
[6] Hyungsoon, X.J. H. Im, Bonsang Gu and Choi, Yang-Kyu, “A dielectricmodulated field-effect transistor for biosensing,” Nature Nanotechnology, vol. 2, p. 5, 2007.Google Scholar
[7] Cheng, Y. Xiong, P. Yun, C. S. Strouse, G. F. Zheng, J. P. Yang, R. S. and Wang, Z. L. “Mechanism and Optimization of pH Sensing Using SnO2 Nanobelt Field Effect Transistors,” Nano. Lett., vol. 8, pp. 4179–4184, 2008.10.1021/nl801696bGoogle Scholar
[8] Yoon, H. Kim, J. Lee, N. Kim, B. and Jang, J. “A Novel Sensor Platform Based on Aptamer-Conjugated Polypyrrole Nanotubes for Label-Free Electrochemical Protein Detection,” Chembiochem, vol. 9, pp. 634–641, 2008.10.1002/cbic.200700660Google Scholar
[9] Xuan, G. Kolodzey, J. Kapoor, V. and Gonye, G. “Characteristics of field-effect devices with gate oxide modification by DNA,” Applied Physics Letters, vol. 87, pp. 103903–103905, 2005.10.1063/1.2041826Google Scholar
[10] Sakata, T. Kamahori, M. and Miyahara, Y. “DNA Analysis Chip Based on Field-Effect Transistors,” Japanese Journal of Applied Physics, vol. 44, pp. 2854–2859, 2005.10.1143/JJAP.44.2854Google Scholar
[11] Baur, G. S. B. Hernando, J. Purrucker, O. Tanaka, M. Nickel, B. Stutzmann, M. and Eickhoff, M., “Chemical functionalization of GaN and AlN surfaces,” Applied Physics Letters, vol. 87, pp. 263901–263903, 2005.10.1063/1.2150280Google Scholar
[12] Bujoli, B. Lane, S. M. Nonglaton, G. Pipelier, M. Leger, J. Talham, D. R. and Tellier, C. “Metal Phosphonates Applied to Biotechnologies: A Novel Approach to Oligonucleotide Microarrays,” Chem. Eur. J., vol. 11, pp. 1980–1989, 2005.10.1002/chem.200400960Google Scholar
[13] Rao, K. S. Rani, S. U. Charyulu, D. K. Kumar, K. N. Lee, H. and Kawai, T. “A novel route for immobilization of oligonucleotides onto modified silica nanoparticles,” Analytica Chimica Acta, vol. 576, p. 7, 2006.10.1016/j.aca.2006.06.019Google Scholar
[14] Jespersen, M. L. Inman, C. E. Kearns, G. J. Foster, E. W. and Hutchison, J. E. “Alkanephosphonates on Hafnium-Modified Gold: A New Class of Self-Assembled Organic Monolayers,” J. AM. CHEM. SOC., vol. 129, p. 5, 2007.10.1021/ja065598aGoogle Scholar
[15] Xu, X. Jindal, V. F. Shahedipour-Sandvik, Bergkvist, M. and Cady, N. C. “Direct immobilization and hybridization of DNA on group III nitride semiconductors” Applied Surface Science, vol. 255, pp. 5905–5909, 2009.10.1016/j.apsusc.2009.01.029Google Scholar
[16] Rashband, W. S. “Image J,” Bethesda, MD: US National Institutes of Health, 1997-2008.Google Scholar