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Making PEG-based Microparticles for Applications in Biology and Medicine

Published online by Cambridge University Press:  01 February 2011

Tom Oliver McDonald ,
Søren Christensen  and
Rein V Ulijn
Tom Oliver McDonald
Affiliation:
[email protected], University of Manchester, School of Materials, Materials Science Centre, Grosvenor Street, Manchester, M1 7HS, United Kingdom
Søren Christensen
Affiliation:
[email protected], VersaMatrix A/S, VersaMatrix A/S, Gamle Carlsberg Vej 10, DK-2500 Valby, Copenhagen, N/A, Denmark
Rein V Ulijn
Affiliation:
[email protected], University of Manchester, School of Materials, Materials Science Centre, Grosvenor Street, Manchester, M1 7HS, United Kingdom
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Abstract

We demonstrate the polymerisation of PEGA hydrogel microparticles with a mean diameter of 16 µm (similar to that of biological cells), and we show that these particles are compatible with enzymes. Furthermore, we demonstrate that enzyme catalysed reactions occur faster with these microparticles than with commercially available macrobeads which are typically 200-400 µm in diameter.

Keywords

polymerparticulatebiomaterial
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1008: Symposium T – The Nature of Design-Utilizing Biology's Portfolio , 2007 , 1008-T05-18
Copyright
Copyright © Materials Research Society 2007

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