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Magnetofluorescent Hybrid Nanoparticles for Phototherapy of Cancer Cells

Published online by Cambridge University Press:  31 January 2011

Dickson K Kirui  and
Carl A Batt
Dickson K Kirui
Affiliation:
[email protected], Cornell University, Biomedical Engineering, 318, Stocking Hall, Ithaca, New York, 14850, United States
Carl A Batt
Affiliation:
[email protected], Cornell University, Food Science, Ithaca, New York, United States
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Abstract

Magnetofluorescent hybrid nanoparticles consisting of Au layer, an iron oxide moiety, and fluorescent molecules could provide a promising platform for development of multimodal imaging and therapy approaches in the treatment of cancer. However, the feasibility of this platform has yet to be fully explored. In this study, we synthesized biocompatible dumbbell-like iron-gold hybrid particles that are superparamagnetic, fluorescent and with strong optical absorption. Furthermore, we showed that hybrid nanoparticles can be conjugated to targeting agents allowing for specific targeting of cancer cells.

Keywords

magnetic propertiesFecellular (material type)
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1189: Symposium MM – Synthesis of Bioinspired Hierarchical Soft and Hybrid Materials , 2009 , 1189-MM05-08
Copyright
Copyright © Materials Research Society 2009

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