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Investigation of Antimicrobial Peptide Salts: Efficacy and Solubility in Surfactant Solutions for Latex Systems

Published online by Cambridge University Press:  26 February 2011

Douglas Wicks ,
Alicyn M Rhoades ,
John S Williamson  and
Bruhaspathy Miriyala
Douglas Wicks
Affiliation:
[email protected], The University of Southern Mississippi, Box 10076, Hattiesburg, MS, 39406, United States
Alicyn M Rhoades
Affiliation:
[email protected], The University of Southern Mississippi, United States
John S Williamson
Affiliation:
[email protected], United States
Bruhaspathy Miriyala
Affiliation:
[email protected]
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Abstract

The study and application of antimicrobial peptides is a growing niche field in the areas of pharmaceutics and medicinal chemistry. As a result, the majority of testing and development is completed under in vitro conditions. The use of synthetically derived antimicrobial peptides in applications outside the medical realm is a relatively untapped field, with the significance of interactions between antimicrobial oligopeptides and the ingredients of polymer systems being largely unknown. Water-based polymer coatings systems are attractive targets for microbial invasion because of their inherent material properties. Water-based polymer latex coatings contain a number of components which aide in stabilization and coalescence of the polymer particles, such as surfactants and polymeric cellulose-derived molecules, with several types of molecular structures existing for each. Microbes are able to flourish within the water phase of the latexes while taking sustenance from these dispersion components, resulting in a loss of properties commonly known as ‘spoilage’. This work addresses the impact of formulation variables, specifically surfactant structure, on the solution and antimicrobial behavior of a model antimicrobial oligopeptides through the use of HT absorbance measurements.

Keywords

additivescombinatorial synthesispolymer
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 894: Symposium LL – Combinatorial Methods and Informatics in Materials Science , 2005 , 0894-LL04-09
Copyright
Copyright © Materials Research Society 2006

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