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Intercalation of Organic Compounds in Lipid Bilayers

Published online by Cambridge University Press:  22 February 2011

K.A. Hamacher ,
H. Kaiser ,
R. Kulasekere  and
D.L. Worcester
K.A. Hamacher
Affiliation:
Research Reactor Facility, Research Park, Columbia, MO 65211
H. Kaiser
Affiliation:
Research Reactor Facility, Research Park, Columbia, MO 65211
R. Kulasekere
Affiliation:
Research Reactor Facility, Research Park, Columbia, MO 65211
D.L. Worcester
Affiliation:
Biology Division, University of Missouri, Columbia, MO 65211
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Abstract

Using neutron diffraction we studied the incorporation of small hydrophobic compounds into bilayers consisting of phosphatidylcholine (PC) and cholesterol. They were found to be localized in a narrow band at the center of the hydrocarbon region, between the two halves of the bilayer. The structures formed by introduction of the compounds are therefore intercalated structures with the long axis of the intercalated molecules lying in the plane of the bilayer. We worked with several bilayers which differed by the length of the hydrocarbon chain of the PC. The quality of the localization depended on the presence of cholesterol, the water content and the PC chain length.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 376: Symposium BB – Neutron Scattering in Materials Science , 1994 , 297
Copyright
Copyright © Materials Research Society 1995

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References

REFERENCES

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