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In vitro Evaluation of Macrophage Adhesion and Proliferation on Alumina

Published online by Cambridge University Press:  01 February 2011

Peishan Liu-Snyder  and
Thomas J. Webster
Peishan Liu-Snyder
Affiliation:
[email protected], Brown University, Division of Engineering, 184 Hope Street,, Providence, RI, 02906, United States, 4018631419
Thomas J. Webster
Affiliation:
[email protected], Brown University, Division of Engineering, 184 Hope Street, Providence, RI, 02912, United States
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Abstract

Extensive interactions of inflammatory cells (such as macrophages) with biomaterials at the host-implant interface are often blamed for failure of implanted biomedical devices [1]. While previous studies have shown increased in vitro and in vivo bone cell (osteoblast) responses on nanophase ceramics [2], few (if any) studies have been conducted to elucidate inflammatory cell responses on such novel materials. In this study, we reported that macrophage adhesion and proliferation on nanophase (97.7 nm grain size) alumina (Al2O3) was significantly less than conventional (187.4 nm grain size) alumina, respectively, after 4, 12, 24 h. The present study provides evidence of the ability of nanophase alumina to down-regulate macrophage adhesion and proliferation, which is imperative for the future consideration of nanophase materials for orthopedic and dental applications.

Keywords

adhesionnanostructurebiomaterial
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 950: Symposium D – Biosurfaces and Biointerfaces , 2006 , 0950-D15-05
Copyright
Copyright © Materials Research Society 2007

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References

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