Hostname: page-component-586b7cd67f-2plfb Total loading time: 0 Render date: 2024-12-01T02:00:28.589Z Has data issue: false hasContentIssue false
  • English
  • Français

Functionalized Porous Silicon in a Simulated Gastrointestinal Tract: Modeling the Biocompatibility of a Monolayer Protected Nanostructured Material

Published online by Cambridge University Press:  01 February 2011

Daniel S. Albrecht ,
Jacob T. Lee ,
Nick Molby ,
Steven D. Rhodes ,
Hieu Minh Dam ,
Jason L. Siegel  and
Lon A. Porter
Daniel S. Albrecht
Affiliation:
[email protected], Wabash College, Chemistry, 301 W. Wabash Ave., Crawfordsville, IN, 47933, United States, 765-361-6284, 765-361-6149
Jacob T. Lee
Affiliation:
Wabash College, Chemistry, 301 W. Wabash Ave., Crawfordsville, IN, 47933, United States
Nick Molby
Affiliation:
Wabash College, Chemistry, 301 W. Wabash Ave., Crawfordsville, IN, 47933, United States
Steven D. Rhodes
Affiliation:
Wabash College, Chemistry, 301 W. Wabash Ave., Crawfordsville, IN, 47933, United States
Hieu Minh Dam
Affiliation:
Wabash College, Chemistry, 301 W. Wabash Ave., Crawfordsville, IN, 47933, United States
Jason L. Siegel
Affiliation:
Wabash College, Chemistry, 301 W. Wabash Ave., Crawfordsville, IN, 47933, United States
Lon A. Porter
Affiliation:
Wabash College, Chemistry, 301 W. Wabash Ave., Crawfordsville, IN, 47933, United States
Get access

Abstract

Owing to its photoluminescent properties and high surface area, porous silicon (por-Si) has shown great potential toward a myriad of applications including optoelectronics, chemical sensors, biocomposite materials, and medical implants. However, the native hydride-termination is only metastable with respect to surface oxidation under ambient conditions. Por-Si samples oxidize and degrade even more quickly when exposed to saline aqueous environments. Borrowing from solution phase synthetic methods, a selection of hydrosilylation reactions has been recently reported for functionalizing organic groups onto oxide-free, hydride-terminated porous silicon surfaces. Monolayers, bound through direct silicon-carbon bonds, are produced via thermal, microwave, Lewis acid, and carbocation mediated pathways. All of these wet, benchtop methods result in the formation of stable monolayers which protect the underlying silicon surface from ambient oxidation and chemical attack. However, no direct comparison of monolayer stability resulting from these diverse mechanisms has been reported. A variety of alkyl monolayers were prepared on porous silicon using the diverse hydrosilylation routes describe above and then immersed into a sequence of simulated gastric and intestinal fluids to replicate the conditions of potential por-Si biosensors or medicinal delivery systems in the human gastrointestinal tract. Degradation of the organic monolayers and oxidation of the underlying por-Si surfaces were monitored using both qualitative and semiquantitative transmission mode Fourier transform infrared spectroscopy (FTIR). Our initial results indicate that methods employing chemical catalysts often incorporate these species within the monolayer as defects, producing less robust surfaces compared to catalyst-free reactions. Regardless, monolayer protected por-Si samples demonstrated superior durability as opposed to the unfunctionalized controls.

Keywords

surface chemistrySisemiconducting
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1063: Symposium OO – Solids at the Biological Interface , 2007 , 1063-OO06-01
Copyright
Copyright © Materials Research Society 2008

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

1. Inoue, A. and Hashimoto, K., Amorphous and Nanocrystalline Materials: Preparation, Properties, and Applications, (Springer, 2001).Google Scholar
2. Canham, L. T., Properties of Porous Silicon, (INSPEC, 1997).Google Scholar
3. Davis, M. E., Nature 417, 813–821 (2002).Google Scholar
4. Rosoff, M., Nano-Surface Chemistry, (Marcel Dekker, 2002).Google Scholar
5. Porter, L. A. Jr., and Buriak, J. M., “Harnessing synthetic versatility toward intelligent interfacial design: organic functionalization of nanostructured silicon surfaces,” Chemistry of Nanostructured Materials (World Scientific, 2003) pp. 227–259; J. M. Buriak, Chem. Rev. 102, 1271 - 1308 (2002).Google Scholar
6. Buriak, J. M., Stewart, M. P., Geders, T. W., Allen, M. J., Choi, H. C., Smith, J., Raftery, D., and Canham, L. T., J. Am. Chem. Soc. 121, 11491–11502 (1999).Google Scholar
7. Boukherroub, R., Petit, A., Loupy, A., Chazalviel, J.-N., and Ozanam, F., J. Phys. Chem. B 107, 13459–13462 (2003).Google Scholar
8. Bateman, J. E., Eagling, R. D., Worrall, D. R., Horrocks, B. R., and Houlton, A., Angew. Chem. Int. Ed. 37, 2683–2685 (1998); R. Boukherroub, S. Morin, D. D. M. Wayner, and D. J. Lockwood, Phys. Stat. Sol. A 182, 117-121 (2000).Google Scholar
9. Schmeltzer, J. M., Porter, L. A. Jr., Stewart, M. P., and Buriak, J. M., Langmuir 18, 2971–2974 (2002).Google Scholar
10. Snyder, R. G., Strauss, H. L., and Elliger, C. A., J. Phys. Chem. 86, 5145–5150 (1982).Google Scholar
11. Sander, L.C., Callis, J. B., and Field, L. R., Anal. Chem. 55, 1068–1075 (1983).Google Scholar