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Fructose Enhanced Reduction of Bacterial Growth on Nanorough Surfaces

Published online by Cambridge University Press:  18 January 2013

N. Gozde Durmus ,
Erik N. Taylor ,
Kim M. Kummer  and
Thomas J. Webster
N. Gozde Durmus
Affiliation:
School of Engineering, Brown University, Providence, RI, USA 02912
Erik N. Taylor
Affiliation:
School of Engineering, Brown University, Providence, RI, USA 02912
Kim M. Kummer
Affiliation:
School of Engineering, Brown University, Providence, RI, USA 02912
Thomas J. Webster
Affiliation:
School of Engineering, Brown University, Providence, RI, USA 02912 Department of Chemical Engineering, Northeastern University, Boston, MA, USA 02215
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Abstract

Biofilms are a major source of medical device-associated infections, due to their persistent growth and antibiotic resistance. Recent studies have shown that engineering surface nanoroughness has great potential to create antibacterial surfaces. In addition, stimulation of bacterial metabolism increases the efficacy of antibacterial agents to eradicate biofilms. In this study, we combined the antibacterial effects of nanorough topographies with metabolic stimulation (i.e., fructose metabolites) to further decrease bacterial growth on polyvinyl chloride (PVC) surfaces, without using antibiotics. We showed for the first time that the presence of fructose on nanorough PVC surfaces decreased planktonic bacteria growth and biofilm formation after 24 hours. Most importantly, a 60% decrease was observed on nanorough PVC surfaces soaked in a 10 mM fructose solution compared to conventional PVC surfaces. In this manner, this study demonstrated that bacteria growth can be significantly decreased through the combined use of fructose and nanorough surfaces and thus should be further studied for a wide range of antibacterial applications.

Keywords

nanostructurebiomaterialadhesion
Type
Articles
Information
MRS Online Proceedings Library (OPL) , Volume 1498: Symposium L – Biomimetic, Bio-inspired and Self-Assembled Materials for Engineered Surfaces and Applications , 2013 , pp. 73 - 78
Copyright
Copyright © Materials Research Society 2013 

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References

REFERENCES

Donlan, R. M., “Biofilms and Device-Associated Infections,” Emerging Infectious Diseases, vol. 7, 2001.CrossRefGoogle ScholarPubMed
Pierce, GE, “Pseudomonas aeruginosa, Candida albicans, and device-related nosocomial infections: implications, trends, and potential approaches for control,” J Ind Microbiol Biotechnol., vol. 32, pp. 309–318, 2005.CrossRefGoogle ScholarPubMed
Burke, J. P., “Infection Control - A Problem for Patient Safety,” N Engl J Med., vol. 348, pp. 651–659, 2003.CrossRefGoogle ScholarPubMed
Fears, R, van der Meer, JWM, and Meulen, VT, “The Changing Burden of Infectious Disease in Europe,” Science, vol. 3, pp. 1–4, 2011.Google Scholar
The Burden of Health Care-Associated Infection Worldwide: A Summary,” World Healtcare Organization (WHO), 2010.Google Scholar
Ducel, G., Fabry, J., and Nicolle, L., “Prevention of hospital-acquired infections. A practical guide,” World Healtcare Organization (WHO), 2002.Google Scholar
Bordi, C. and de Bentzmann, S., “Hacking into bacterial biofilms: a new therapeutic challenge,” Annals of intensive care, vol. 1, p. 19, 2011 2011.CrossRefGoogle ScholarPubMed
Rello, J, Torres, A, Ricart, M, Valles, J, Gonzalez, J, Artigas, A, and R.-R. R., “Ventilator-associated pneumonia by Staphylococcus aureus. Comparison of methicillin-resistant and methicillin-sensitive episodes.,” Am J Respir Crit Care Med., vol. 150, pp. 1545–9., 1994.CrossRefGoogle ScholarPubMed
Adair, CG, Gorman, SP, Feron, BM, Byers, LM, Jones, DS, Goldsmith, CE, Moore, JE, Kerr, JR, Curran, MD, Hogg, G, Webb, CH, McCarthy, GJ, and M. KR., “Implications of endotracheal tube biofilm for ventilator-associated pneumonia.,” Intensive Care Med., vol. 25, pp. 1072–6, 1999.CrossRefGoogle ScholarPubMed
Puckett, SD, Taylor, E, Raimondo, T, and Webster, TJ., “The relationship between the nanostructure of titanium surfaces and bacterial attachment.,” Biomaterials, vol. 31, pp. 706–13, 2010.CrossRefGoogle ScholarPubMed
Allison, KR, Brynildsen, MP, and Collins, JJ., “Metabolite-enabled eradication of bacterial persisters by aminoglycosides,” Nature, vol. 73, pp. 216–20, 2011.CrossRefGoogle Scholar
Durmus, NG, Taylor, EN, Inci, F, Kummer, KM, Tarquinino, KM, and Webster, TJ., “Fructose enhanced reduction of bacterial growth on nanorough surfaces.,” Int Journal of Nanomedicine 2012.Google ScholarPubMed