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Fabrication and antimicrobial effects of silver nanoparticle-poly(N-isopropylacrylamide)-poly(ferrocenylsilane) hydrogel composites

Published online by Cambridge University Press:  13 July 2012

Xiaofeng Sui ,
Xueling Feng ,
Andrea Di Luca ,
Clemens A. van Blitterswijk ,
Lorenzo Moroni ,
Mark A. Hempenius  and
G. Julius Vancso
Xiaofeng Sui
Affiliation:
Department of Materials Science and Technology of Polymers, MESA+ Institute for Nanotechnology, University of Twente, P.O. Box 217, 7500 AE Enschede, The Netherlands.
Xueling Feng
Affiliation:
Department of Materials Science and Technology of Polymers, MESA+ Institute for Nanotechnology, University of Twente, P.O. Box 217, 7500 AE Enschede, The Netherlands.
Andrea Di Luca
Affiliation:
Department of Tissue Regeneration, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, P.O. Box 217, 7500 AE Enschede, The Netherlands.
Clemens A. van Blitterswijk
Affiliation:
Department of Tissue Regeneration, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, P.O. Box 217, 7500 AE Enschede, The Netherlands.
Lorenzo Moroni
Affiliation:
Department of Tissue Regeneration, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, P.O. Box 217, 7500 AE Enschede, The Netherlands.
Mark A. Hempenius
Affiliation:
Department of Materials Science and Technology of Polymers, MESA+ Institute for Nanotechnology, University of Twente, P.O. Box 217, 7500 AE Enschede, The Netherlands.
G. Julius Vancso
Affiliation:
Department of Materials Science and Technology of Polymers, MESA+ Institute for Nanotechnology, University of Twente, P.O. Box 217, 7500 AE Enschede, The Netherlands.
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Abstract

Novel hydrogels composed of thermo-responsive poly(N-isopropylacrylamide) (PNIPAM) and redox-responsive poly(ferrocenylsilane) (PFS) macromolecules were formed by photopolymerization. PFS chains bearing acrylate side groups were copolymerized with NIPAM and N,N’-methylenebisacrylamide in tetrahydrofuran in a predetermined ratio under ultraviolet light-emitting diode (UV-LED) irradiation at a wavelength of 365 nm, in the presence of a photoinitiator. Crosslinking occurred smoothly, providing homogeneous hydrogels. The equilibrium swelling ratio, rheology and morphology of these hybrid PNIPAM-PFS-based hydrogels were investigated. In-situ fabrication of silver nanoparticles inside the hydrogel network via reduction of silver nitrate by the PFS chains led to hydrogel composites. These composites showed strong antimicrobial activity while maintaining a high biocompatibility with cells.

Keywords

biomedicalcompositemetal
Type
Articles
Information
MRS Online Proceedings Library (OPL) , Volume 1453: Symposium GG/AAA – Functional Hybrid Nanoparticles and Capsules with Engineered Structures and Properties , 2012 , mrss12-1453-gg11-04
Copyright
Copyright © Materials Research Society 2012

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