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Enhanced Cytocompatibility Properties of Hydroxyapatite Doped with Trivalent Ions

Published online by Cambridge University Press:  17 March 2011

Elizabeth A. Massa ,
Elliott B. Slamovich  and
Thomas J. Webster
Elizabeth A. Massa
Affiliation:
Department of Biomedical Engineering and School of Materials Science Engineering, Purdue University, West Lafayette, IN 47907, U.S.A.
Elliott B. Slamovich
Affiliation:
Department of Biomedical Engineering and School of Materials Science Engineering, Purdue University, West Lafayette, IN 47907, U.S.A.
Thomas J. Webster
Affiliation:
Department of Biomedical Engineering and School of Materials Science Engineering, Purdue University, West Lafayette, IN 47907, U.S.A.
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Abstract

Hydroxyapatite (HA) is a bone-like ceramic used as a coating for dental and orthopedic implants. It is well known for its good cytocompatibility properties, but is limited in use due to its high solubility within the body and mechanical properties that differ from surrounding tissue and bone. The present in vitro study investigated a variety of dopants as a way to further enhance the good cytocompatibility properties of HA as well as address these problematic properties. The dopants investigated were divalent (magnesium and zinc) and trivalent (yttrium, lanthanum, indium, and bismuth) ions. Of the trivalent ions, yttrium and indium have smaller ionic radii than calcium. The present study showed osteoblast adhesion to be statistically greater (p < 0.1) on yttrium-doped HA and indium-doped HA than on undoped HA. Since yttrium and indium are both trivalent ions of a smaller ionic radius than calcium, and other ions of different size and charge did not show significant changes in osteoblast adhesion, these results suggest that substituting divalent calcium with a trivalent ion of smaller size encourages osteoblast adhesion.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 711: Symposia FF/GG/HH – Advanced Biomaterials--Characterization, Tissue Engineering and Complexity , 2001 , HH3.10.1
Copyright
Copyright © Materials Research Society 2002

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References

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