Hostname: page-component-586b7cd67f-g8jcs Total loading time: 0 Render date: 2024-11-24T16:53:08.849Z Has data issue: false hasContentIssue false
  • English
  • Français

Electro-Optical Detection of Single Nanoparticles on a Nanopore-Optofluidic Chip

Published online by Cambridge University Press:  30 December 2014

Shuo Liu ,
Yue Zhao ,
Matthew Stott ,
Joshua W. Parks ,
Aaron R. Hawkins  and
Holger Schmidt
Shuo Liu
Affiliation:
School of Engineering, University of California, Santa Cruz, 1156 High Street, Santa Cruz, CA 95064 USA
Yue Zhao
Affiliation:
Department of Electrical & Computer Engineering, 459 Clyde Building, Brigham Young University, Provo, UT 84602 USA
Matthew Stott
Affiliation:
Department of Electrical & Computer Engineering, 459 Clyde Building, Brigham Young University, Provo, UT 84602 USA
Joshua W. Parks
Affiliation:
School of Engineering, University of California, Santa Cruz, 1156 High Street, Santa Cruz, CA 95064 USA
Aaron R. Hawkins
Affiliation:
Department of Electrical & Computer Engineering, 459 Clyde Building, Brigham Young University, Provo, UT 84602 USA
Holger Schmidt
Affiliation:
School of Engineering, University of California, Santa Cruz, 1156 High Street, Santa Cruz, CA 95064 USA
Get access

Abstract

A solid-state nanopore was integrated into an optofluidic sensor chip, liquid-core anti-resonant reflecting optical waveguide (ARROW). The solid-state nanopore worked as a smart gate, which simultaneously provided characteristic electrical signals and controlled the entry of single nanoparticles into the liquid-core channel. The subsequent fluorescence detection further identified the nanoparticles by providing optical signals within a specific wavelength range. In this work, correlated electrical and optical detection of single nanoparticles, H1N1 viruses, and λ-DNA molecules was demonstrated. Different types of particles in a mixture were successfully discriminated. Moreover, the flow velocity in the liquid-core channel was extracted with the help of combined analysis of electrical and optical signals. Enhanced electrical sensitivity using a solid-state nanopore with a thin limiting aperture sculpted by SiO2 deposition was also shown.

Keywords

sensornanoscaleoptoelectronic
Type
Articles
Information
MRS Online Proceedings Library (OPL) , Volume 1720: Symposium D – Materials and Concepts for Biomedical Sensing , 2014 , mrsf14-1720-d09-02
Copyright
Copyright © Materials Research Society 2014 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Dekker, C., Nat. Nanotechnol. 2, 209 (2007).CrossRefGoogle Scholar
Howorka, S. and Siwy, Z.S., Nat. Biotechnol. 30, 506 (2012).CrossRefGoogle Scholar
Venkatesan, B.M. and Bashir, R., Nat. Nanotechnol. 6, 615 (2011).CrossRefGoogle Scholar
Chen, A., Eberle, M.M., Lunt, E.J., Liu, S., Leake, K., Rudenko, M.I., Hawkins, A.R., and Schmidt, H., Lab. Chip 11, 1502 (2011).CrossRefGoogle Scholar
Rudenko, M.I., Kühn, S., Lunt, E.J., Deamer, D.W., Hawkins, A.R., and Schmidt, H., Biosens. Bioelectron. 24, 3258 (2009).CrossRefGoogle Scholar
Parks, J.W., Cai, H., Zempoaltecatl, L., Yuzvinsky, T.D., Leake, K., Hawkins, A.R., and Schmidt, H., Lab. Chip 13, 4118 (2013).CrossRefGoogle Scholar
Ozcelik, D., Phillips, B.S., Parks, J.W., Measor, P., Gulbransen, D., Hawkins, A.R., and Schmidt, H., Lab. Chip 12, 3728 (2012).CrossRefGoogle Scholar
Parks, J.W., Cai, H., Zempoaltecatl, L., Yuzvinsky, T.D., Leake, K., Hawkins, A.R., and Schmidt, H., Lab. Chip 13, 4118 (2013).CrossRefGoogle Scholar
Parks, J.W., Olson, M.A., Kim, J., Ozcelik, D., Cai, H., R.C. Jr, Patterson, J.L., Mathies, R.A., Hawkins, A.R., and Schmidt, H., Biomicrofluidics 8, 054111 (2014).CrossRefGoogle Scholar
Liu, S., Zhao, Y., Parks, J.W., Deamer, D.W., Hawkins, A.R., and Schmidt, H., Nano Lett. 14, 4816 (2014).CrossRefGoogle Scholar
Heng, J.B., Aksimentiev, A., Ho, C., Marks, P., Grinkova, Y.V., Sligar, S., Schulten, K., and Timp, G., Nano Lett. 5, 1883 (2005).CrossRefGoogle Scholar
Wu, L., Liu, H., Zhao, W., Wang, L., Hou, C., Liu, Q., and Lu, Z., Nanoscale Res. Lett. 9, 140 (2014).CrossRefGoogle Scholar
Wanunu, M., Morrison, W., Rabin, Y., Grosberg, A.Y., and Meller, A., Nat. Nanotechnol. 5, 160 (2010).CrossRefGoogle Scholar
Liu, S., Yuzvinsky, T.D., and Schmidt, H., ACS Nano 7, 5621 (2013).CrossRefGoogle Scholar