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Development of Electrochemiluminescence and Surface Plasmon Resonance based Immunosensors with Surface Accumulable Molecules.

Published online by Cambridge University Press:  24 January 2012

Ryoji Kurita
Ryoji Kurita*
Affiliation:
National Institute of Advanced Industrial Science and Technology 1-1-1 Higashi, Tsukuba, Ibaraki, JAPAN
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Abstract

The electrochemiluminescence (ECL) and surface plasmon resonance (SPR) based immunosensors for measuring a trace level of disease markers are shown. It is well known that thiols form a self-assembled monolayer on a metal surface, and this has been widely used to modify metal surfaces. We employed this characteristic for a highly sensitive immunosensors by obtaining a surface pre-concentration of thiol molecules formed by the enzymatic reaction of labeled antibody.

Keywords

biomedicalsurface chemistrysensor
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1415: Symposium HH/II/TT – MEMS, BioMEMS and Bioelectronics–Materials and Devices , 2012 , mrsf11-1415-ii02-01
Copyright
Copyright © Materials Research Society 2012

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References

REFERENCES

1. Kurita, Ryoji, Yokota, Yoshimi, Sato, Yukari, Mizutani, Fumio and Niwa, Osamu, Analytical Chemistry, 78 (2006) 5525–5531 Google Scholar
2. Kurita, Ryoji, Yokota, Yoshimi, Ueda, Akio and Niwa, Osamu, Analytical Chemistry, 79 (2007) 9572–9576 Google Scholar
3. Kurita, Ryoji, Nakamoto, Kohei, Kato, Dai and Niwa, Osamu, Chemistry Letters, 38 (2009) 804–805.Google Scholar
4. Kurita, Ryoji, Arai, Kumi, Nakamoto, Kohei, Kato, Dai and Niwa, Osamu, Analytical Chemistry, 82 (2010) 1692–1697.Google Scholar