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Determining loading kinetics of drug releasing degradable shape-memory polymers

Published online by Cambridge University Press:  13 February 2012

Christian Wischke ,
Susi Steuer  and
Andreas Lendlein
Christian Wischke
Affiliation:
Center for Biomaterial Development and Berlin-Brandenburg Center for Regenerative Therapies, Institute for Polymer Research, Helmholtz-Zentrum Geesthacht, Kantstr. 55, 14513 Teltow, Germany
Susi Steuer
Affiliation:
present address: Intervet Innovation GmbH, 55270 Schwabenheim, Germany
Andreas Lendlein
Affiliation:
Center for Biomaterial Development and Berlin-Brandenburg Center for Regenerative Therapies, Institute for Polymer Research, Helmholtz-Zentrum Geesthacht, Kantstr. 55, 14513 Teltow, Germany
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Abstract

Modern concepts for biofunctional implants often comprise the controlled release of bioactive compounds to gain specific biofunctionalities. Here, amorphous and semi-crystalline copolyester-based shape-memory polymer (SMP) networks are reported as matrix for pharmaceutical applications. Drug loading of such crosslinked networks by swelling techniques requires tools to determine the actual payload. In this report, the capability of determining loading kinetics by mass increase or changes of drug concentration in the swelling medium is explored for two types of copolyester-based SMP networks differing in their crosslinking chemistry. Nitrofurantoin and ethacridine lactate served as hydrophobic and hydrophilic model drugs. It was found, that the absolute values of the determined payload did not systematically agree with those obtained by the more reliable technique of network cleavage and spectrophotometric quantification. However, the studies indicate that for both types of SMP materials and both drugs, maximum incorporation of the drugs occurred within a few hours. The time until equilibration depended on the network properties.

Keywords

biomaterialpolymermemory
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1403: Symposium V – Multifunctional Polymer-Based Materials , 2012 , mrsf11-1403-v14-03
Copyright
Copyright © Materials Research Society 2012

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References

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