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Depth dependent osmotic and swelling properties of cartilage

Published online by Cambridge University Press:  12 January 2012

Candida Silva ,
Iren Horkayne-Szakaly ,
Preethi Chandran ,
Emilios K. Dimitriadis ,
David Lin ,
Christopher Papanicolas ,
Peter J. Basser  and
Ferenc Horkay
Candida Silva
Affiliation:
Section on Tissue Biophysics and Biomimetics, Program in Pediatric Imaging and Tissue Sciences, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
Iren Horkayne-Szakaly
Affiliation:
Section on Tissue Biophysics and Biomimetics, Program in Pediatric Imaging and Tissue Sciences, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
Preethi Chandran
Affiliation:
Section on Tissue Biophysics and Biomimetics, Program in Pediatric Imaging and Tissue Sciences, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD 20892, USA
Emilios K. Dimitriadis
Affiliation:
National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD 20892, USA
David Lin
Affiliation:
Section on Tissue Biophysics and Biomimetics, Program in Pediatric Imaging and Tissue Sciences, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
Christopher Papanicolas
Affiliation:
Section on Tissue Biophysics and Biomimetics, Program in Pediatric Imaging and Tissue Sciences, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
Peter J. Basser
Affiliation:
Section on Tissue Biophysics and Biomimetics, Program in Pediatric Imaging and Tissue Sciences, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
Ferenc Horkay
Affiliation:
Section on Tissue Biophysics and Biomimetics, Program in Pediatric Imaging and Tissue Sciences, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
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Abstract

Articular cartilage is a low-friction, load-bearing tissue located at joint surfaces. It experiences static and dynamic forces including shear, compression and tension. We investigate the relationship between structure and function by measuring the osmotic and mechanical properties in cartilage layers as a function of the distance from the articular surface. Atomic force microscopy is used to probe the mechanical properties at high spatial resolution. The mechanical measurements are complemented by osmotic swelling pressure observations made on the same samples using a novel tissue osmometer. The results show that the osmotic modulus significantly depends on the distance from the articular surface. Its value is highest in the deep zone and lowest in the middle zone.

Keywords

biomedicaltissueelastic properties
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1418: Symposium LL/MM – Gels and Biomedical Materials , 2012 , mrsf11-1418-ll03-08
Copyright
Copyright © Materials Research Society 2012

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References

REFERENCES

1. Mow, V.C; Zhu, W.; Ratcliffe, A. Structure and function of articular cartilage and meniscus, in Basic Orthopedic Biomechanics, eds. Mow, V.C. and Hayes, W.C. Raven Press, New York, 1991.Google Scholar
2. Won, C.; Sah, L.R. Biomechanics of Articular Cartilage, in An Introductory Text to Bioengineering (Advanced Series in Biomechanics), eds. Chien, S.; Chen, P.C.Y.; Fung, Y.C. World Scientific Publishing Co. 2008.Google Scholar
3. Ateshian, G.A.; Hung, C.T. The natural Synovial Joint: Properties of Cartilage, J. Engineering Tribibolgy, 220, 657-670 (2006).Google Scholar
4. Horkay, F.; Horkayne-Szakaly, I.; Basser, P.J. Measurement of the Osmotic Properties of Thin Polymer Films and Biological Tissue Samples, Biomacromolecules 6, 988–993 (2005).CrossRefGoogle ScholarPubMed
5. Sauerbray, G.Z. Use of quartz vibrator for weighing thin films on a microbalance. Z. Phys. 155, 206-212 (1959).Google Scholar
6. Horkay, F.; Zrinyi, M.: Studies on Mechanical and Swelling Behavior of Polymer Networks Based on the Scaling Concept, 4. Extension of the Scaling Approach for Gels Swollen to Equilibrium in a Diluent of Arbitrary Activity, Macromolecules 15, 1306-1310 (1982).CrossRefGoogle Scholar
7. Horkay, F.; Tasaki, I.; Basser, P.: Osmotic Swelling of Polyelectrolyte Hydrogels in Physiological Salt Solutions, Biomacromolecules, 1, 84-90 (2000).CrossRefGoogle Scholar
8. Lin, D.; Horkay, F. Nanomechanics of polymer gels and biological tissues: A critical review of analytical approaches in the Hertzian regime and beyond. Soft Matter, 4, 669-682 (2008).CrossRefGoogle ScholarPubMed
9. Chandran, P.L.; Dimitriadis, E.K.; Basser, P.J.; Horkay, F. Probing interactions between aggrecan and mica surface by the atomic force microscopy. Journal of Polymer Science Part B: Polymer Physics 48, 2575-2581 (2010).CrossRefGoogle ScholarPubMed
10. Basser, P.J.; Schneiderman, R.; Bank, R.A.; Wachtel, E.; Maroudas., A.: Mechanical properties of the collagen network in human articular cartilage as measured by osmotic stress technique. Arch. Biochem. Biophys. 351, 207–219 (1998).CrossRefGoogle ScholarPubMed
11. Schinagl, R.M.; Gurskis, D.; Chen, A.C.; Sah, R.L.: Depth-dependent confined compression modulus of full-thickness bovine articular cartilage. Journal of Orthopaedic Research 15, 499-506 (1997).CrossRefGoogle ScholarPubMed