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Characterization of 3C-SiC (100) as a platform for detecting the onset of acute myocardial infarction (AMI)

Published online by Cambridge University Press:  25 May 2012

Alexandra Oliveros ,
Anthony Guiseppi-Elie ,
Mark Jaroszeski  and
Stephen E. Saddow
Alexandra Oliveros
Affiliation:
Department of Electrical Engineering, University of South Florida, 4202 East Fowler Avenue, Tampa, Florida 33620-5350
Anthony Guiseppi-Elie
Affiliation:
Center for Bioelectronics, Biosensors and Biochips (C3B), Clemson University Advanced Materials Center, 100 Technology Drive, Anderson, South Carolina 29625
Mark Jaroszeski
Affiliation:
Department of Chemical and Biomedical Engineering, University of South Florida, 4202 East Fowler Avenue, Tampa, Florida 33620-5350
Stephen E. Saddow
Affiliation:
Department of Electrical Engineering, University of South Florida, 4202 East Fowler Avenue, Tampa, Florida 33620-5350 Department of Molecular Pharmacology and Physiology, USF, 4202 East Fowler Avenue, Tampa, Florida 33620-5350
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Abstract

In this work we describe the characterization of anti-myoglobin immobilization on 3C-SiC (100) by means of surface modification with 3-aminopropyltriethoxysilane (APTES). Surface water contact angle measurements were used to compare the wettability of 3C-SiC (100) before (16 ±3°) and after APTES layer formation (61 ±1°). Atomic force microscopy (AFM) was used to confirm the homogenous formation of APTES and anti-myoglobin immobilization with EDC-sulfo NHS coupling. For the APTES surfaces no significant change in the surface roughness was obtained whereas with anti-myoglobin surfaces, particles on the order of ∼60 nm in diameter with a globular shape were observed.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1433: Symposium H – Silicon Carbide 2012—Materials, Processing and Devices , 2012 , mrss12-1433-h07-03
Copyright
Copyright © Materials Research Society 2012

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References

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