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α-BSM™: A Calcium Phosphate Delivery Vehicle

Published online by Cambridge University Press:  15 February 2011

D. Knaack  and
D.D. Lee
D. Knaack
Affiliation:
ETEX Corporation, University Park at MIT, 350 Massachusetts Avenue, Cambridge, MA 02139, Tel (617) 577-7270, Fax (617) 577-7170
D.D. Lee
Affiliation:
ETEX Corporation, University Park at MIT, 350 Massachusetts Avenue, Cambridge, MA 02139, Tel (617) 577-7270, Fax (617) 577-7170
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Abstract

α-BSM™ is an injectable endothermically setting calcium phosphate bone substitute. α-BSM™ has been shown to be effective in promoting the healing of surgically created critical size defects and restoring bone biomechanical strength in several animal models. It has received regulatory clearance for orthopedic indications in both Canada and Europe and for dental and craniofacial indications in the United States.

α-BSM™ is distinguished as a bone substitute by its prolonged working time at room temperature, and rapid hardening at body temperature. These properties, as well as its compatibility with a variety of aqueous hydrating agents, make α-BSM™ an attractive vehicle for the in situ delivery of therapeutic agents. In vitro studies have shown that antibiotics, such as gentamicin, can be stably incorporated into α-BSM™ prior to and during hardening, and that delivery kinetics can be controlled with the appropriate formulation and preparative procedures. The setting reaction is also compatible with biologically active proteins. rhBMP-2 has been incorporated into α-BSM™ and was demonstrated to be effective in stimulating ectopic bone formation in soft tissue and accelerating the restoration of a differentiated phenotype in a rabbit osteotomy model.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 550: Symposium GG/HH/II – Biomedical Materials-Drug Delivery, Implants and Tissue Engr , 1998 , 221
Copyright
Copyright © Materials Research Society 1999

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